The Language of Proteins

  • J. H. Parish
Conference paper

Abstract

The expression of genes involves processes for which the decoding of a language represents a metaphor. The final part of the process involves the acquisition of a three dimensional fold and to extend the metaphor the protein sequence is like a prose description of a three dimensional object. The rules for interpreting this language might not be the same for all protein families and, in this sense, the protein sequences might be regarded as automata.

Keywords

Starch Hepatitis Codon Rubber Influenza 

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References

  1. 1.
    Hubbard, T.J.P., Murzin, A.G., Brenner, S.E., & Chothia, C. SCOP: A structural classification of proteins database. 1997; Nucl. Acids Res. 25, 236–239.CrossRefGoogle Scholar
  2. 2.
    Ison J.C., Parish J.H., Blades M.J., Daniel S.C., Bleasby A.J., Findlay J.B.C.F. A Key Residues Approach to Protein Fold Detection - Development of a Novel Method for generating Signatures for Protein Families based on Analysis of Contacts between Elements of Secondary Structure 1998; submittedGoogle Scholar
  3. 3.
    Jones D.T. Progress in protein structure prediction. 1997 Curr. Biol. 7: 377–387CrossRefGoogle Scholar
  4. 4.
    Needleman S.B., Wunsch C.D. A general method applicable to the search for similarities in the amino acid sequence of two proteins. 1970; J. Mol. Biol. 48: 443–453CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 1999

Authors and Affiliations

  • J. H. Parish
    • 1
  1. 1.School of Biochemistry and Molecular BiologyThe University of LeedsLeedsUK

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