Photodynamic therapy (PDT) involves the therapeutic combination of a photosensitiser administered to the patient and its activation by light. This combination generates the formation of highly reactive oxygen intermediates which cause irreversible tissue injury and necrosis. Oxygen must be present in the tissue to effect damage. Van Tappeiner used this combination with eosin as the photosensitiser and artificial light for the treatment of skin carcinomas as early as 1903 but it was not until the 1970s that PDT became more widely investigated.
KeywordsPsoriasis Porphyrin Phthalocyanine Dermatol Weinstein
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References and Further Reading
Systemic Photodynamic Therapy
- Lui H, Hruza L, McLean D et al (1995) Photodynamic therapy of malignant skin tumors with BPD Verteporfin (benzoporphyrin derivative). Lasers Surg Med Suppl 7:44Google Scholar
Topical Photodynamic Therapy for Cutaneous Malignancies
- Stables GI, Stringer MR, Robinson DJ (1997) Treatment of cutaneous T-cell lymphoma by topical aminolaevulinic acid photo-dynamic therapy. Br J Dermatol 137 (Suppl 50):50Google Scholar
Photodynamic Therapy for Benign Skin Disease
- Grossman M, Wimberely J, Dwyer P et al (1995) PDT for hirsutism. Lasers Surg Med Suppl 7:44Google Scholar
- Nelson JS, McCullough JL, Berns MW (1997) Principles and applications of photodynamic therapy in dermatology. In Arndt KA, Dover JS, Olbricht SM (eds) Lasers in cutaneous and aesthetic surgery. Lippincott-Raven, Philadelphia, pp 370–372Google Scholar
- Varma S, Wilson H, Kurwa HA, Charman C, Gambles B, Anstey A (1999) One year relapse rates for Bowen’s disease, basal cell carcinomas and solar keratoses treated by photodynamic therapy: analysis of 189 lesions. Br J Dermatol 141 (Suppl 55):114Google Scholar
- Weinstein GD, McCullough JL, Nelson JS, Berns MW, McCormick A (1991) Low dose Photofrin II photodynamic therapy of psoriasis. Clin Res 39:509AGoogle Scholar