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Neo-adjuvant Therapy

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Modern Management of Cancer of the Rectum

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Abstract

A number of advances have been made in the adjuvant management of resectable rectal cancer. In patients with clinically resectable disease, pelvic radiation therapy decreases local recurrence and, in the preoperative setting, increases the chance of sphincter preservation. The addition of systemic chemotherapy further enhances local control and improves survival. The potential additional benefits of preoperative radiation therapy (with or without chemotherapy) include enhanced sphincter preservation and less toxicity.

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Authors
  1. B. D. Minsky
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  2. C.-H. Köhne
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  3. C. Greco
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Editor information

Editors and Affiliations

  1. Department of Surgery, Whiston Hospital, Prescot, University of Liverpool, Merseyside, UK, L35 5DR

    Riccardo A. Audisio MD

  2. Professorial Department of Surgery, Nottingham City Hospital, Hucknall Road, Nottingham, UK, NG5 1PB

    James G. Geraghty MD, PhD, MCh, FRCS (Irel)

  3. Department of Surgery, Section of Colon and Rectal Surgery, Saint Louis University Health Sciences Center, 3635 Vista @ Grand Blvd., Saint Louis, USA, PO Box 15250, M063110-0250

    Walter E. Longo MD, FACS, FASCRS

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Minsky, B.D., Köhne, CH., Greco, C. (2001). Neo-adjuvant Therapy. In: Audisio, R.A., Geraghty, J.G., Longo, W.E. (eds) Modern Management of Cancer of the Rectum. Springer, London. https://doi.org/10.1007/978-1-4471-0331-8_5

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  • DOI: https://doi.org/10.1007/978-1-4471-0331-8_5

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