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Metastatic Rectal Cancer

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Modern Management of Cancer of the Rectum

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Abstract

Carcinomas of the rectum are defined anatomically as tumours arising in the distal 15 cm of the large bowel. The rectum lies below the peritoneal reflection, hence, unlike colonic carcinomas, the growth of rectal tumours is not limited by the serosa. At presentation, 50% of patients with rectal carcinoma are considered to be operable; of these, 50% will have a curative resection. The likelihood of developing local recurrence or metastatic disease after curative surgery increases with Dukes’ stage from A to C and with the extent of tumour penetration of the bowel, Gunderson and Sosin Stage 1–3. The 5-year survival rates for patients with rectal carcinoma according to Dukes’ stage are as follows: Dukes’ A 80%, Dukes’ B 55% and Dukes’ C 32%. The management of locally recurrent rectal cancer depends upon its extent and whether it is amenable to curative treatment. Ultimately, 25% of patients with B2 disease and 50% of patients with C disease develop local recurrence.

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Authors
  1. K. Sumpter
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  2. D. Cunningham
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Editors and Affiliations

  1. Department of Surgery, Whiston Hospital, Prescot, University of Liverpool, Merseyside, UK, L35 5DR

    Riccardo A. Audisio MD

  2. Professorial Department of Surgery, Nottingham City Hospital, Hucknall Road, Nottingham, UK, NG5 1PB

    James G. Geraghty MD, PhD, MCh, FRCS (Irel)

  3. Department of Surgery, Section of Colon and Rectal Surgery, Saint Louis University Health Sciences Center, 3635 Vista @ Grand Blvd., Saint Louis, USA, PO Box 15250, M063110-0250

    Walter E. Longo MD, FACS, FASCRS

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© 2001 Springer-Verlag London

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Sumpter, K., Cunningham, D. (2001). Metastatic Rectal Cancer. In: Audisio, R.A., Geraghty, J.G., Longo, W.E. (eds) Modern Management of Cancer of the Rectum. Springer, London. https://doi.org/10.1007/978-1-4471-0331-8_14

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  • DOI: https://doi.org/10.1007/978-1-4471-0331-8_14

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1070-5

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