Trauma; Haemorrhage; Ototoxicity

  • Leslie Michaels
  • Henrik B. Hellquist


The temporal bone is affected in the majority of fractures of the base of the skull. Although such lesions are frequent at autopsy, there has hardly been any study of fractures of the temporal bone in pathological material and what knowledge there is has largely been derived from clinical and radiological observations.


Hair Cell Temporal Bone Outer Hair Cell Spiral Ganglion Stria Vascularis 
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  1. 1.
    Schuknecht HF, Neff WD, Perlman HB. An experimental study of auditory damage following blows to the head. Ann Otol Rhinol Laryngol 1951;60:272–289Google Scholar
  2. 2.
    Paparella MM, Melnick W. Stimulation deafness In: Graham AB (ed) Sensorineural hearing processes and disorders. Little Brown, London, 1967, p 427Google Scholar
  3. 3.
    Walsted A, Garbarsch C, Michaels L. Effect of craniotomy and cerebrospinal fluid loss on the inner ear. An experimental study. Acta Otolaryngol (Stockh) 1994;114:626–631CrossRefGoogle Scholar
  4. 4.
    Sidek D, Michaels L, Wright A. Changes in the inner ear in vestibular schwannoma. In: Iurato S, Veldman JE (eds) Progress in human auditory and vestibular histopathology. Kugler Publications, Amsterdam, 1996Google Scholar
  5. 5.
    Graham JM, Ashcroft P. Direct measurement of cerebrospinal fluid pressure through the cochlea in a congenitally deaf child with Mondini dysplasia undergoing cochlear implantation. Am J Otol 1999;20:205–208PubMedGoogle Scholar
  6. 6.
    Smith N, Bain B, Michaels L et al. Atypical Ph negative chronic myeloid leukaemia presenting as sudden profound deafness. J Clin Pathol 1991;44:1033–1034PubMedCrossRefGoogle Scholar
  7. 7.
    Slack RW, Wright A, Michaels L et al. Inner hair cell loss and intracochlear clot in the preterm infant. Clin Otolaryngol 1986;11:443–446PubMedCrossRefGoogle Scholar
  8. 8.
    Amatuzzi MG, Northrop C, Liberman MC et al. Selective inner hair cell loss in premature infants and cochlea pathology patterns from NICU autopsies. J Pediatrics, in pressGoogle Scholar
  9. 9.
    Michaels L, Gould SJ, Wells M. The microslicing method in the study of temporal bone changes in the perinatal period: an interim report. Acta Otolaryngol (Stockh) 1985;423(suppl):9–14CrossRefGoogle Scholar
  10. 10.
    Lindsay JR, Proctor LR, Work WP. Histopathologic inner ear changes in deafness due to neomycin in a human. Laryngoscope 1960;70:382–392PubMedGoogle Scholar
  11. 11.
    Matz GJ, Wallace TH, Ward PH. The ototoxicity of kanamycin. A comparative histopathological study. Laryngoscope 1965;75:1690–1698PubMedCrossRefGoogle Scholar
  12. 12.
    Michaels L. Ear, nose and throat histopathology. Springer, London, 1987CrossRefGoogle Scholar
  13. 13.
    Keene M, Hawke M, Barber HO et al. Histopathological findings in clinical gentamycin ototoxicity. Arch Otolaryngol 1982;108:65–70PubMedCrossRefGoogle Scholar
  14. 14.
    Tange RA, Huizing EH. Hearing loss and inner ear changes in a patient suffering from severe gentamycin ototoxicity. Arch Otorhinolaryngol 1980;228:113–121PubMedCrossRefGoogle Scholar
  15. 15.
    Pollak A, Felix H. Histopathological features of the spiral ganglion and cochlear nerve in temporal bones from three patients with profound hearing loss. Acta Otolaryngol 1985;423(suppl):59–66CrossRefGoogle Scholar
  16. 16.
    Sone M, Schachern PA, Paparella MM. Loss of spiral ganglion cells as primary manifestation of aminoglycoside ototoxicity. Hear Res 1998;115:217–223PubMedCrossRefGoogle Scholar
  17. 17.
    Matz GJ, Lerner SA. Drug ototoxicity. In: Beagley HA (ed) Audiology and audiological medicine, vol 1. Oxford University Press, Oxford, 1981, pp 573–592Google Scholar
  18. 18.
    Li L, Nevill G, Forge A. Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear. J Comp Neurol 1995;355:405–417PubMedCrossRefGoogle Scholar
  19. 19.
    Forge A. The endolymphatic surface of the stria vascularis in the guinea pig and the effects of ethacrynic acid as shown by scanning electron microscopy. Clin Otolaryngol 1980;5:87–95PubMedCrossRefGoogle Scholar
  20. 20.
    Matz GJ. The ototoxic effects of ethacrynic acid in man and animals. Laryngoscope 1976;86:1065–1086PubMedCrossRefGoogle Scholar
  21. 21.
    Schuknecht HF. The pathology of several disorders of the inner ear which cause vertigo. South Med J 1964;57:1161–1167PubMedCrossRefGoogle Scholar
  22. 22.
    Wright CG, Schaefer SD. Inner ear histopathology in patients treated with cis-platinum. Laryngoscope 1982;92:1408–1413PubMedCrossRefGoogle Scholar
  23. 23.
    Hinojosa R, Riggs LC, Strauss M et al. Temporal bone histopathology of cisplatin ototoxicity. Am J Otol 1995;16:731–740PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2001

Authors and Affiliations

  • Leslie Michaels
    • 1
    • 2
    • 3
  • Henrik B. Hellquist
    • 4
    • 5
  1. 1.Department of Histopathology, UCL Medical SchoolRockefeller BuildingLondonUK
  2. 2.Royal Free and UCL Medical SchoolUniversity of LondonUK
  3. 3.Royal National Throat, Nose nad Ear HospitalLondonUK
  4. 4.Department of Laboratory Medicine and PathologyHamad Medical CorporationDohaQatar
  5. 5.Haukeland University HospitalBergenNorway

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