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Pathology of Invasive Squamous Cell Carcinoma

  • Leslie Michaels
  • Henrik B. Hellquist

Abstract

The TNM system of staging of laryngeal carcinoma divides laryngeal tumours into supraglottic, glottic and subglottic.1 The terms are not used purely as anatomical descriptions, but, more than this, to designate three embryologically distinct regions, each of which gives rise to its own type of neoplasm. Origin of a carcinoma from two adjacent regions is held to indicate “invasion” or “extension” from one of these regions to the other and hence to necessitate a higher, i.e. more serious, grading. The concept of the separate embryological development of the three parts of the larynx is unproven, however. The most frequent site for the localisation of carcinoma is the anterior part of the vocal cords and the diameter of the tumour is usually small. It may be that a similarly small neoplasm happens to arise across the arbitrarily designated boundary of glottis and supraglottis or glottis and subglottis. The behaviour of such a neoplasm is not necessarily more aggressive. Laryngeal neoplasms, however, do possess different innate biological properties of growth activity and aggressiveness, which may be related to original size but cannot be predicted from involvement of more than one region.

Keywords

Vocal Cord Squamous Carcinoma Radiation Necrosis Laryngeal Carcinoma Thyroid Cartilage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Larynx. In: American Joint Committee on Cancer: AJCC Cancer Staging Manual, 5th edn. Lippincott-Raven Publishers, Philadelphia, 1997, pp 41–46Google Scholar
  2. 2.
    Edmundson WR. Microscopic grading of cancer and its practical implication. Arch Dermat Syphil 1948:57: 141–150CrossRefGoogle Scholar
  3. 3.
    Jakobsson PA, Eneroth CM, Killander D et al. Histologic classification and grading of malignancy in carcinoma of the larynx. Acta Radiol 1973;12:1–7CrossRefGoogle Scholar
  4. 4.
    Bryne M, Koppang HS, Lilleng R et al. Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol 1992; 166:375–381PubMedCrossRefGoogle Scholar
  5. 5.
    Wiernik G, Millard PR, Haybittle JL. The predictive value of histological classification into degrees of differentiation of squamous cell carcinoma of the larynx and hypopharynx compared with the survival of patients. Histopathol 1991;19:411–417CrossRefGoogle Scholar
  6. 6.
    Meyer-Breitung E, Burkhardt A. Tumours of the larynx. Histopathology and clinical inferences. Springer-Verlag, Berlin, 1988Google Scholar
  7. 7.
    Thaler ER, Montone K, Tucker J et al. Delphian lymph node in laryngeal carcinoma: a whole organ study. Laryngoscope 1997;107:332–334PubMedCrossRefGoogle Scholar
  8. 8.
    Michaels L. Pathology of the larynx. Springer, Heidelberg, Berlin, New York, 1984CrossRefGoogle Scholar
  9. 9.
    Lloyd GAS, Michaels L, Phelps PD. The demonstration of cartilaginous involvement in laryngeal carcinoma by computerized tomography. Clin Otolaryngol 1981:6: 171–177PubMedCrossRefGoogle Scholar
  10. 10.
    Zbaren P, Greiner R, Kengelbacher M. Stoma recurrence after laryngectomy: an analysis of risk factors. Otolaryngol Head Neck Surg 1996;114:569–575PubMedCrossRefGoogle Scholar
  11. 11.
    Harrer WV, Lewis PL. Carcinoma of the larynx with cardiac metastases. Arch Otolaryngol 1970;91:382–384PubMedCrossRefGoogle Scholar
  12. 12.
    O’Brien PH, Carlson R, Stuebner EA et al. Distant metastases in epidermoid cell carcinoma of the head and neck. Cancer 1971;27:304–307PubMedCrossRefGoogle Scholar
  13. 13.
    Lederman M. Radiotherapy of cancer of the larynx. J Laryngol Otol 1970;84:867–896PubMedCrossRefGoogle Scholar
  14. 14.
    Stell PM, Morrison MD. Radiation necrosis of the larynx. Etiology and management. Arch Otolaryngol 1973:98: 111–113PubMedCrossRefGoogle Scholar
  15. 15.
    Henk JM, Kunkler PB, Smith CW. Radiotherapy and hyperbaric oxygen in head and neck cancer. Final report of first controlled clinical trial. Lancet 1977;II:101–103CrossRefGoogle Scholar
  16. 16.
    Keene M, Harwood AR, Bryce DP et al. Histopathological study of radionecrosis in laryngeal carcinoma. Laryngoscope 1981;92:173–180Google Scholar
  17. 17.
    Hermans R, Pameijer FA, Mancuso AA et al. CT findings in chondroradionecrosis of the larynx. AJNR Am J Neuroradiol 1998;19:711–718PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2001

Authors and Affiliations

  • Leslie Michaels
    • 1
    • 2
    • 3
  • Henrik B. Hellquist
    • 4
    • 5
  1. 1.Department of Histopathology, UCL Medical SchoolRockefeller BuildingLondonUK
  2. 2.Royal Free and UCL Medical SchoolUniversity of LondonUK
  3. 3.Royal National Throat, Nose nad Ear HospitalLondonUK
  4. 4.Department of Laboratory Medicine and PathologyHamad Medical CorporationDohaQatar
  5. 5.Haukeland University HospitalBergenNorway

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