Non-epidermoid Epithelial Neoplasms

  • Leslie Michaels
  • Henrik B. Hellquist


Most cases of carcinoma of the nasal cavity and paranasal sinuses — a rare entity — are of epidermoid type so that the numbers of non-epidermoid carcinomas are very small indeed. Sinonasal adenocarcinomas are primarily of two types, one originating from the surface epithelium and the other from mucosal seromucinous glands (most of the latter being salivary gland adenocarcinomas of different types). The exact incidence of each of these types of sinonasal adenocarcinomas is extremely difficult to access as almost every report on the subject has made no distinction between adenocarcinoma from surface epithelium and seromucinous gland adenocarcinomas (apart from adenoid cystic carcinoma). However, one can estimate sinonasal adenocarcinomas to represent from 6% to 13% of sinonasal malignancies.1, 2


Salivary Gland Nasal Cavity Paranasal Sinus Adenoid Cystic Carcinoma Pleomorphic Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Robin PE, Powell DJ, Stassbie JM. Carcinoma of the nasal cavity and paranasal sinuses: incidence and presentation of different histological types. Clin Otolaryngol 1979;4:431–456PubMedCrossRefGoogle Scholar
  2. 2.
    Harbo G, Grau C, Bundgaard T et al. Cancer of the nasal cavity and paranasal sinuses. A clinico-pathological study of 277 patients. Acta Oncol 1997;36:45–50PubMedCrossRefGoogle Scholar
  3. 3.
    Shanmugaratnam K, Sobin LH. Histological typing of tumours of the upper respiratory tract and ear. WHO International Histological Classification of Tumours, 2nd edn. Springer-Verlag, Berlin, 1991Google Scholar
  4. 4.
    Heffner DK, Hyams VJ, Hauck KW et al. Low-grade adenocarcinoma of the nasal cavity and paranasal sinuses. Cancer 1982;50:312–322PubMedCrossRefGoogle Scholar
  5. 5.
    Gallo O, Franchi A, Fini-Storchi I et al. Prognostic significance of c-erbB-2 oncoprotein expression in intestinal-type adenocarcinoma of the sinonasal tract. Head Neck 1998;20:224–231PubMedCrossRefGoogle Scholar
  6. 6.
    Wilhelmsson B, Hellquist H, Olofsson J et al. Nasal cuboidal metaplasia with dysplasia. Precursor to adenocarcinoma in wood-dust exposed workers? Acta Otolaryngol (Stockh) 1985;99:641–648CrossRefGoogle Scholar
  7. 7.
    Hanslian L, Kadlec K. The products of heat-disintegrated wood (in Czech). Pracovni Lékarství 1964;16:276–282PubMedGoogle Scholar
  8. 8.
    Michaels L. Lung changes in woodworkers. Can Med Assoc J 1967;96:1150–1155PubMedGoogle Scholar
  9. 9.
    Macbeth R. Malignant disease of the paranasal sinuses. J Laryngol Otol 1965;79:592–612PubMedCrossRefGoogle Scholar
  10. 10.
    Acheson ED, Cowdell RH, Hadfield E et al. Nasal cancer in woodworkers in the furniture industry. Br Med J 1968;II:587–596CrossRefGoogle Scholar
  11. 11.
    Kleinsasser O, Schroeder HG. Pathologie und Klinik der Adenokarzinome der Nase nach Holzstaubexposition. Strahlenther Onkol 1989;165:437–440PubMedGoogle Scholar
  12. 12.
    Franquemont DW, Fechner RE, Mills SE. Histologic classification of sinonasal intestinal-type adenocarcinoma. Am J Surg Pathol 1991;15:368–375PubMedCrossRefGoogle Scholar
  13. 13.
    Saber AT, Nielsen LR, Dictor M et al. K-ras mutations in sinonasal adenocarcinomas in patients occupationally exposed to wood or leather dust. Cancer Lett 1998;126:59–65PubMedCrossRefGoogle Scholar
  14. 14.
    Van den Oever R. Occupational exposure to dust and sinonasal cancer. An analysis of 386 cases reported to the N.C.C.S.F. Cancer Registry. Acta Otorhinolaryngol Belg 1996;50:19–24PubMedGoogle Scholar
  15. 15.
    Klinterberg C, Olofsson J, Hellquist H et al. Adenocarcinoma of the ethmoid sinuses. A review of 28 cases with special reference to wood dust exposure. Cancer 1984;54:482–488CrossRefGoogle Scholar
  16. 16.
    Franchi A, Gallo O, Santucchi M. Clinical relevance of the histological classification of sinonasal intestinal-type adenocarcinomas. Hum Pathol 1999;30:1140–1145PubMedCrossRefGoogle Scholar
  17. 17.
    Compagno J, Wong RT. Intranasal mixed tumours (pleomorphic adenomas). A clinicopathologic study of 40 cases. Am J Clin Pathol 1977;68:213–218PubMedGoogle Scholar
  18. 18.
    Johns ME, Regezi JA, Batsakis JG. Oncocytic neoplasms of salivary glands. An ultrastructural study. Laryngoscope 1977;87:862–871PubMedCrossRefGoogle Scholar
  19. 19.
    Perzin KH, Cantor JO, Johannessen JV. Acinic cell carcinoma arising in the nasal cavity: report of a case with ultrastructural observations. Cancer 1981;47:1818–1822PubMedCrossRefGoogle Scholar
  20. 20.
    Billroth T. Beobachtunge über Geschwülste der speicheldresen. Virchows Arch [Pathol Anat Physiol] 1859; 17:357–375CrossRefGoogle Scholar
  21. 21.
    Harbo G, Grau C, Bundgaard T et al. Cancer of the nasal cavity and paranasal sinuses. A clinico-pathological study of 277 patients. Acta Oncol 1997;36:45–50PubMedCrossRefGoogle Scholar
  22. 22.
    Pitman KT, Prokopakis EP, Aydogan B et al. The role of skull base surgery for the treatment of adenoid cystic carcinoma of the sinonasal tract. Head Neck 1999;21:402–407PubMedCrossRefGoogle Scholar
  23. 23.
    Da-Quan M, Guang-Yan Y. Tumours of the minor salivary glands. A clinicopathologic study of 243 cases. Acta Otolaryngol (Stockh) 1987;103:325–331Google Scholar

Copyright information

© Springer-Verlag London 2001

Authors and Affiliations

  • Leslie Michaels
    • 1
    • 2
    • 3
  • Henrik B. Hellquist
    • 4
    • 5
  1. 1.Department of Histopathology, UCL Medical SchoolRockefeller BuildingLondonUK
  2. 2.Royal Free and UCL Medical SchoolUniversity of LondonUK
  3. 3.Royal National Throat, Nose nad Ear HospitalLondonUK
  4. 4.Department of Laboratory Medicine and PathologyHamad Medical CorporationDohaQatar
  5. 5.Haukeland University HospitalBergenNorway

Personalised recommendations