Development of Bile Acids as Anti-Apoptotic and Neuroprotective Agents in Treatment of Ocular Disease

  • Stephanie L. Foster
  • Cristina Kendall
  • Allia K. Lindsay
  • Alison C. Ziesel
  • Rachael S. Allen
  • Sheree S. Mosley
  • Esther S. Kim
  • Ross J. Molinaro
  • Henry F. Edelhauser
  • Machelle T. Pardue
  • John M. Nickerson
  • Jeffrey H. Boatright
Chapter
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 2)

Abstract

The hydrophilic bile acids ursodeoxycholic acid and tauroursodeoxycholic acid are approved by regulatory bodies of many countries for treatment of gallstones and cirrhosis. Delivery is by oral administration and side effects are minimal. This chapter reviews evidence demonstrating that systemic treatment with the two compounds is protective in models of neuronal and retinal degeneration and injury. Variability in the regulation of circulating bile acids suggests a need to explore local delivery as a treatment modality. Our initial experiments testing in vivo intraocular injections and in vitro transscleral permeability indicate that this is feasible and efficacious.

Keywords

Superoxide Glycine Penicillin Retina Neuropathy 

Notes

Acknowledgments

Original work presented here was supported in part by The Abraham J. and Phyllis Katz Foundation, the Foundation Fighting Blindness (FFB), Research to Prevent Blindness (RPB), and NIH NEI grants R01EY014026, R01EY016470, R24EY017045, P30EY006360, and T32EY007092.

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Copyright information

© American Association of Pharmaceutical Scientists 2011

Authors and Affiliations

  • Stephanie L. Foster
    • 1
  • Cristina Kendall
    • 1
  • Allia K. Lindsay
    • 1
  • Alison C. Ziesel
    • 1
    • 2
  • Rachael S. Allen
    • 1
  • Sheree S. Mosley
    • 1
  • Esther S. Kim
    • 1
  • Ross J. Molinaro
    • 3
  • Henry F. Edelhauser
    • 4
  • Machelle T. Pardue
    • 5
  • John M. Nickerson
    • 6
  • Jeffrey H. Boatright
    • 7
  1. 1.Department of OphthalmologyEmory University School of MedicineAtlantaUSA
  2. 2.Department of Biological SciencesUniversity of AlbertaEdmontonCanada
  3. 3.Department of Pathology and Laboratory MedicineEmory University School of MedicineAtlantaUSA
  4. 4.Emory University Eye CenterEmory UniversityAtlantaUSA
  5. 5.Department of Ophthalmology and Rehabilitation Research and Development Center of Excellence, Atlanta VA Medical CenterEmory University School of MedicineAtlantaUSA
  6. 6.Department of OphthalmologyEmory UniversityAtlantaUSA
  7. 7.Department of OphthalmologyEmory University School of MedicineAtlantaUSA

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