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Hydrogels for Ocular Posterior Segment Drug Delivery

  • Gauri P. Misra
  • Thomas W. Gardner
  • Tao L. Lowe
Chapter
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 2)

Abstract

This chapter discusses emerging hydrogel technology for drug delivery to the back of the eye to treat retinal diseases. The review includes design, characterization and optimization of hydrogels, and advantages and disadvantages of intravitreally and subconjunctivally administrated hydrogels for retinal therapy. Future direction of hydrogel technology for targeted and sustained delivery of drugs to the retina for individualized medicine is also laid out.

Keywords

Diabetic Macular Edema Retinal Vein Occlusion PLGA Microsphere Retinal Pigment Epithelium Drug Release Kinetic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The work was supported by the NIH, JDRF and Coulter Foundation grants. TWG is the Jack and Nancy Turner Professor.

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Copyright information

© American Association of Pharmaceutical Scientists 2011

Authors and Affiliations

  • Gauri P. Misra
    • 1
  • Thomas W. Gardner
    • 2
  • Tao L. Lowe
    • 3
    • 4
  1. 1.Department of Pharmaceutical SciencesThomas Jefferson University, School of PharmacyPhiladelphiaUSA
  2. 2.Department of Ophthalmology, Cellular and Molecular PhysiologyPenn State College of MedicineHersheyUSA
  3. 3.Department of Pharmaceutical Sciences, School of PharmacyThomas Jefferson UniversityPhiladelphiaUSA
  4. 4.Department of Pharmaceutical Sciences, College of PharmacyUniversity of Tennessee Health Science CenterMemphisUSA

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