Negative Regulators of NF-κB Activation and Type I Interferon Pathways



The transcription factor NF-κB and type I interferon (IFN) are both important modulators of the innate immune system. NF-κB plays a key role in the up-regulation of pro-inflammatory cytokines, adhesion molecules and chemokines (Oncogene 25:6758–6780, 2006), whereas type I IFN is essential for the initiation of an antiviral state in cells, and for the detection of malignant cells (Microbes Infect 4(6):647–655, 2002).

This chapter summarizes the inhibitory mechanisms both endogenous and from pathogens that target NF-κB and the type I IFN system. Without internal regulatory systems, deregulated NF-κB and type I IFN can cause inflammatory diseases and malignancy in cells. Pathogens also target both signalling systems to replicate within the host.


Human Papilloma Virus Newcastle Disease Virus Classical Swine Fever Virus Human Papilloma Virus Bovine Respiratory Syncytial Virus 
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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.School of Biochemistry and ImmunologyTrinity College DublinDublinIreland

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