Negative Regulators of NF-κB Activation and Type I Interferon Pathways

Chapter

Abstract

The transcription factor NF-κB and type I interferon (IFN) are both important modulators of the innate immune system. NF-κB plays a key role in the up-regulation of pro-inflammatory cytokines, adhesion molecules and chemokines (Oncogene 25:6758–6780, 2006), whereas type I IFN is essential for the initiation of an antiviral state in cells, and for the detection of malignant cells (Microbes Infect 4(6):647–655, 2002).

This chapter summarizes the inhibitory mechanisms both endogenous and from pathogens that target NF-κB and the type I IFN system. Without internal regulatory systems, deregulated NF-κB and type I IFN can cause inflammatory diseases and malignancy in cells. Pathogens also target both signalling systems to replicate within the host.

Keywords

Hepatitis Influenza Serine Proline Lysine 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.School of Biochemistry and ImmunologyTrinity College DublinDublinIreland

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