Animal Models of Hyperinsulinemia, Insulin Resistance, and Cancer

  • Ruslan Novosyadlyy
  • Archana Vijayakumar
  • Yvonne Fierz
  • Derek LeRoithEmail author
Part of the Energy Balance and Cancer book series (EBAC, volume 1)


Numerous lines of evidence indicate that insulin and its receptor regulate cell proliferation, survival and transformation, and thus, tumorigenesis [52]. Indeed, the fact that insulin has a potent tumor-promoting activity has been known for a long time. In wild-type animals, administration of exogenous insulin markedly enhances development of experimental breast and colon tumors [34, 68, 117]. In contrast, insulinopenia in animals with chemically-induced type 1 diabetes (T1D) results in a significantly reduced tumor growth, which is restored after insulin administration [29, 67, 112, 113]. Moreover, intraportal implantation of pancreatic islets in rats with T1D creates an insulin-enriched microenvironment, which promotes hepatocarcinogenesis [43]. The aforementioned studies thus link insulin and cancer mechanistically, and indicate that insulin plays the role of both a tumor initiator and promoter.


Mammary Gland Development Aberrant Crypt Focus Colon Carcinogenesis Monogenic Obesity Mouse Mammary Gland Development 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Ruslan Novosyadlyy
    • 1
  • Archana Vijayakumar
    • 1
  • Yvonne Fierz
    • 1
  • Derek LeRoith
    • 1
    Email author
  1. 1.Division of Endocrinology, Diabetes and Bone Diseases, Department of MedicineMount Sinai School of MedicineNew YorkUSA

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