Abstract
Constitutive behavior of living cells is in deep relationship with their biological properties. For that reason gathering the most detailed information on cell mechanical behavior as it is feasible becomes extremely useful in assessing therapeutic protocols. However, investigation of elastic properties of living cells is a fairly complicated process that requires the use of advanced sensing devices. For example, Atomic Force Microscopy (AFM) is a research tool largely used by biomedical engineers and biophysicists for studying cell mechanics. Experimental data can be given in input to finite element models to predict cell behavior and to simulate the tissue response to biophysical, chemical or pharmacological stimuli of different nature. The paper analyzes different aspects involved in the numerical simulation of AFM measurements on living cells focusing in particular on the effect of constitutive behavior.
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References
Costa K.D. “Single cell elastography: probing for disease with the atomic force microscope” Disease Markers, 19, 139–154, 2004.
Suresh S. “Biomechanics and biophysics of cancer cells”, Acta Biomaterialia, 3, 413–438, 2007.
Vinckier A., Semenza G. “Measuring elasticity of biological materials by atomic force microscopy”, FEBS Letters, 430, 12–16, 2008. (4)
Costa K.D., Sim A. J.F., Yin C.P. “Non-Hertzian approach to analyzing mechanical properties of endothelial cells probed by atomic force microscopy”, Journal of Biomechanical Engineering, 128, 176–184, 2006.
Charles R., Sekatski S., Dietler G., Catsicas S., Lafont F., Kasas S. “Stiffness tomography by atomic force microscopy”, Biophysical Journal, 97, 674–677, 2009.
Bhushan B. “Handbook of Nanotechnology”, Springer, 2007.
Hertz H. “On the contact of elastic solids”, J. Reine Angew. Mathematik, 92, 156–171, 1881.
Johnson K.L. “Contact Mechanics”, Cambridge University Press, New York, 1985.
Mooney M. A theory of large elastic deformation. Journal of Applied Physics, 11, 582–592, 1940.
Rivlin R.S. “Large elastic deformations of isotropic materials I. Fundamental concepts”. Philosophical Transactions of the Royal Society of London, A240, 459–490, 1948.
Rivlin R.S., “Large elastic deformations of isotropic materials IV. Further developments of the general theory”. Philosophical Transactions of the Royal Society of London, A241, 379–397, 1948.
Briscoe B.J., Sebastian K.S., Adams M.J., “The effect of indenter geometry on the elastic response to indentation”. Journal of Physics D: Applied Physics, 27, 1156–1162, 1994.
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Frassanito, M.C., Lamberti, L., Pappalettere, C. (2011). Elastic Properties of Living Cells. In: Proulx, T. (eds) Experimental and Applied Mechanics, Volume 6. Conference Proceedings of the Society for Experimental Mechanics Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9792-0_3
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DOI: https://doi.org/10.1007/978-1-4419-9792-0_3
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