Abstract
Lymph node metastasis is frequently seen in most primary abdominal malignant tumors. The tumor cells enter lymphatic vessels and travel to the lymph nodes along lymphatic drainage pathways. The lymphatic vessels and lymph nodes generally accompany the blood vessels supplying or draining the organs. They are all located in the subperitoneal space within the ligaments, mesentery, mesocolon, and extra peritoneum. Metastasis to the lymph nodes generally follows the nodal station in a stepwise direction—i.e., from the primary tumor to the nodal station that is closest to the primary tumor and then progresses farther away but within the lymphatic drainage pathways. Metastasis to a nodal station that is farther from the primary tumor without involving the nodal station close to the primary tumor (“skip” metastasis) is rare. The key to understanding the pathways of lymphatic drainage of each individual organ is to understand the ligamentous, mesenteric, and peritoneal attachments and the vascular supply of that organ [1].
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References
Meyers MA, Charnsangavej C, Oliphant M. Meyers’ dynamic radiology of the abdomen: normal and pathologic anatomy. New York: Springer; 2010.
McDaniel KP, Charnsangavej C, DuBrow RA, et al. Pathways of nodal metastasis in carcinomas of the cecum, ascending colon, and transverse colon: CT demonstration. AJR Am J Roentgenol. 1993;161:61–4.
Granfield CA, Charnsangavej C, Dubrow RA, Varma DG, et al. Regional lymph node metastases in carcinoma of the left side of the colon and rectum: CT demonstration. AJR Am J Roentgenol. 1992;159:757–61.
Gest TPP. Anatomy: Medcharts. New York: Iloc; 1994.
Dorfman RE, Alpern MB, Gross BH, Sandler MA. Upper abdominal lymph nodes: criteria for normal size determined with CT. Radiology. 1991;180:319–22.
Dodd 3rd GD, Baron RL, Oliver 3rd JH, et al. Enlarged abdominal lymph nodes in end-stage cirrhosis: CT-histopathologic correlation in 507 patients. Radiology. 1997;203:127–30.
Morón FE, Szklaruk J. Learning the nodal stations in the abdomen. Br J Radiol. 2007;80:841–8.
Harisinghani MG, Barentsz J, Hahn PF, et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med. 2003;348:2491–9.
Torabi M, Aquino SL, Harisinghani MG. Current concepts in lymph node imaging. J Nucl Med. 2004;45:1509–18.
Frija J, Bourrier P, Zagdanski AM, De Kerviler E. Diagnosis of a malignant lymph node. J Radiol. 2005;86:113–25.
Harisinghani MG, Saksena MA, Hahn PF, et al. Ferumoxtran-10-enhanced MR lymphangiography: does contrast-enhanced imaging alone suffice for accurate lymph node characterization? AJR Am J Roentgenol. 2006;186:144–8.
Egner JR. AJCC cancer staging manual. JAMA. 2010;304:1726–7.
Kobayashi S, Takahashi S, Kato Y, et al. Surgical treatment of lymph node metastases from hepatocellular carcinoma. J Hepatobiliary Pancreat Sci. 2011;18:559–66.
Hartgrink HH, van de Velde CJH, Putter H, et al. Extended lymph node dissection for gastric cancer: who may benefit? Final results of the randomized Dutch gastric cancer group trial. J Clin Oncol. 2004;22:2069–77.
Coburn NG. Lymph nodes and gastric cancer. J Surg Oncol. 2009;99:199–206.
Dicken BJ, Bigam DL, Cass C, et al. Gastric adenocarcinoma. Ann Surg. 2005;241:27–39.
Taylor FGM, Swift RI, Blomqvist L, Brown G. A systematic approach to the interpretation of preoperative staging MRI for rectal cancer. AJR Am J Roentgenol. 2008;191:1827–35.
Steup WH, Moriya Y, van de Velde CJH. Patterns of lymphatic spread in rectal cancer. A topographical analysis on lymph node metastases. Eur J Cancer. 2002;38:911–8.
Granfield CA, Charnsangavej C, Dubrow RA, et al. Regional lymph node metastases in carcinoma of the left side of the colon and rectum: CT demonstration. AJR Am J Roentgenol. 1992;159:757–61.
McDaniel K, Charnsangavej C, DuBrow R, et al. Pathways of nodal metastasis in carcinomas of the cecum, ascending colon, and transverse colon: CT demonstration. Am J Roentgenol. 1993;161:61–4.
Granfield C, Charnsangavej C, Dubrow R, et al. Regional lymph node metastases in carcinoma of the left side of the colon and rectum: CT demonstration. Am J Roentgenol. 1992;159:757–61.
Rajput A, Romanus D, Weiser MR, et al. Meeting the 12 lymph node (LN) benchmark in colon cancer. J Surg Oncol. 2010;102:3–9.
Wolpin BM, Meyerhardt JA, Mamon HJ, Mayer RJ. Adjuvant treatment of colorectal cancer. CA Cancer J Clin. 2007;57:168–85.
Iafrate F, Laghi A, Paolantonio P, et al. Preoperative staging of rectal cancer with MR imaging: correlation with surgical and histopathologic findings. Radiographics. 2006;26:701–14.
American Cancer Society. Cancer facts and figures. 2011. Accessible at: http://www.cancer.org/Research/CancerFactsFigures/CancerFactsFigures/cancer-facts-figures-2011. Accessed 31 May 2012.
Karakiewicz PI, Lewinshtein DJ, Chun FK-H, et al. Tumor size improves the accuracy of TNM predictions in patients with renal cancer. Eur Urol. 2006;50:521–8. discussion 529.
Lughezzani G, Capitanio U, Jeldres C, et al. Prognostic significance of lymph node invasion in patients with metastatic renal cell carcinoma: a population-based perspective. Cancer. 2009;115:5680–7.
Capitanio U, Jeldres C, Patard J-J, et al. Stage-specific effect of nodal metastases on survival in patients with non-metastatic renal cell carcinoma. BJU Int. 2009;103:33–7.
Pantuck AJ, Zisman A, Dorey F, et al. Renal cell carcinoma with retroperitoneal lymph nodes: role of lymph node dissection. J Urol. 2003;169:2076–83.
Israel GM, Bosniak MA. Renal imaging for diagnosis and staging of renal cell carcinoma. Urol Clin North Am. 2003;30:499–514.
Takahashi T, Ishikura H, Motohara T, et al. Perineural invasion by ductal adenocarcinoma of the pancreas. J Surg Oncol. 1997;65:164–70.
Kayahara M, Nakagawara H, Kitagawa H, Ohta T. The nature of neural invasion by pancreatic cancer. Pancreas. 2007;35:218–23.
Pawlik TM, Gleisner AL, Cameron JL, et al. Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer. Surgery. 2007;141:610–8.
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Harisinghani, M.G. (2013). Abdominal Lymph Node Anatomy. In: Harisinghani, M. (eds) Atlas of Lymph Node Anatomy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9767-8_3
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