Preconditioning for Surgical Brain Injury

  • Cherine H. KimEmail author
  • Han Chen
  • John H. Zhang
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


The invasiveness of neurosurgical procedures into the delicate nervous system inevitably results in collateral damage to normal tissue surrounding the operative site. The manipulation of tissue during these procedures leads to a host of postoperative complications characteristic of surgical brain injury (SBI) that include brain edema and hemorrhage. These complications are not only detrimental to the recovery of neurosurgical patient but may also hinder more aggressive therapeutic strategies. In this chapter, we will describe the rodent model for SBI, review its known mechanisms of pathophysiology in literature, and discuss potential preconditioning therapeutic agents for SBI.


Traumatic Brain Injury Brain Edema KATP Channel Central Nervous System Injury Brain Water Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.School of MedicineLoma Linda UniversityLoma LindaUSA
  2. 2.Department of Neurological SurgeryUniversity of New MexicoAlbuquerqueUSA
  3. 3.Loma Linda UniversityLoma LindaUSA

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