Preconditioning for Surgical Brain Injury
The invasiveness of neurosurgical procedures into the delicate nervous system inevitably results in collateral damage to normal tissue surrounding the operative site. The manipulation of tissue during these procedures leads to a host of postoperative complications characteristic of surgical brain injury (SBI) that include brain edema and hemorrhage. These complications are not only detrimental to the recovery of neurosurgical patient but may also hinder more aggressive therapeutic strategies. In this chapter, we will describe the rodent model for SBI, review its known mechanisms of pathophysiology in literature, and discuss potential preconditioning therapeutic agents for SBI.
KeywordsTraumatic Brain Injury Brain Edema KATP Channel Central Nervous System Injury Brain Water Content
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