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Ischemic Preconditioning-Mediated Signaling Pathways Leading to Tolerance Against Cerebral Ischemia

  • Srinivasan Narayanan
  • Jake T. Neumann
  • Kahlilia C. Morris-Blanco
  • Miguel A. Perez-Pinzon
  • Hung Wen LinEmail author
Chapter
Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Abstract

Cerebral ischemia, most notably in the form of stroke, is the leading cause of morbidity and mortality resulting in long-term disability in the USA. Approximately 800,000 strokes occur each year in the USA, and 87 % of all strokes in the world are caused by embolism, thrombosis, or systemic hemorrhage/hypoperfusion, all of which are a form of cerebral ischemia (Roger et al. 2011). The medical cost for the treatment of stroke in the USA was estimated to be $25 billion in 2007 (Roger et al. 2011). Due to this great burden, a fundamental understanding of cerebral ischemia and the inciting cellular dysfunction is imperative for the development of new therapies to combat this growing epidemic.

Keywords

Reactive Oxygen Species Nitric Oxide Cerebral Ischemia Mitochondrial Membrane Potential Middle Cerebral Artery Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Srinivasan Narayanan
    • 1
  • Jake T. Neumann
    • 1
  • Kahlilia C. Morris-Blanco
    • 1
  • Miguel A. Perez-Pinzon
    • 2
  • Hung Wen Lin
    • 1
    Email author
  1. 1.Cerebral Vascular Disease Research Laboratories, Department of Neurology, Leonard M. Miller School of MedicineUniversity of MiamiMiamiUSA
  2. 2.Cerebral Vascular Disease Research Laboratories, Neuroscience Program, Department of Neurology, Leonard M. Miller School of MedicineUniversity of MiamiMiamiUSA

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