Conditioning Studies in Focal Cerebral Ischemia: Model Selection, Physiological Monitoring, and Other Methodological Issues

  • Thaddeus S. NowakJr.Email author
  • Liang Zhao
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


The earliest studies of preconditioning in experimental stroke examined the potential impact of such interventions on the key variable of cerebral perfusion. Based on limited regional or temporal sampling, these were interpreted to suggest that protection could be dissociated from overt CBF changes, and the majority of conditioning studies in experimental stroke have since focused on cellular protection mechanisms. However, evolving results indicate a strong association between delayed improvements in penumbral perfusion and subsequent tissue protection. This presentation will briefly consider the strengths and limitations of commonly used focal brain ischemia models and address the requirements for adequately monitoring those physiological parameters that are recognized to influence outcome in experimental stroke. It will then summarize observations regarding changes in blood flow and relevant physiological variables in conditioning models.


Middle Cerebral Artery Middle Cerebral Artery Occlusion Ischemic Precondition Cortical Spreading Depression Middle Cerebral Artery Territory 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of NeurologyUniversity of Tennessee Health Science CenterMemphisUSA

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