Theme and Variation on N-Aryl-1, 8-Napthalimides: Minimal Modification to Red-Shifted Fluorescence and Applications in Fluorescent Chemosensors

  • Premchendar Nandhikonda
  • Zhi Cao
  • Michael D. Heagy
Part of the Reviews in Fluorescence book series (RFLU, volume 2009)


Our continuing efforts into the development of N-aryl-1,8-naphthalic dicarboximides (NI) as dual fluorescent (DF) dyes for biomedical applications has led to new insights into the photophysical features that these simple dyes can be designed to display. Consequently, the development of new DF dyes with improved fluorescent properties represents a major focus of our research. The first section of this review presents results involving a “minimal modification approach” to red-shifted absorption and fluorescence in NIs and affords some key design concepts for improved DF dyes. In this section, we demonstrate the significant effect of appropriately placed charges can have on the emission properties of these unique dyes. In the next section, dual fluorescent probes for the ions of potassium and sodium are introduced with the NI framework and crown ether receptors. The ratiometric features of these dyes from absorption as well as fluorescence spectroscopy are highlighted. Finally, in the third section, we demonstrate dual fluorescence detection of saccharides with the same DF dye component as our ion probe, in this case, however, a simple phenylboronic acid is utilized as a saccharide binding component.


Crown Ether Boronic Acid Dual Fluorescence Internal Charge Transfer Tetrabutylammonium Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Premchendar Nandhikonda
    • 1
  • Zhi Cao
    • 1
  • Michael D. Heagy
    • 1
  1. 1.Department of ChemistryNew Mexico Institute of Mining and TechnologySocorroUSA

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