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Biosensing with Nanoparticles as Electrogenerated Chemiluminsecence Emitters

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NanoBiosensing

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Electrogenerated chemiluminescence (ECL), also known as electrochemiluminescence, is the luminescence generated by relaxation of exited-state molecules that are produced during an electrochemically initiated reaction [1]. The phenomenon of ECL has been known for a long time. Reports date back as far as 1927 for the light emission of Grignard compounds at applied potentials [2] and 1929 for the ECL of luminol [3]. Along with subsequent publications concentrated on the investigation of the mechanism and nature of ECL, especially of polyaromatic hydrocarbons (PAHs) and metal complexes [4–6], ECL has now become a very powerful analytical technique and been widely used in the areas of, for example, immunoassay, food and water testing, and biowarfare agent detection [7, 8]. As a method of producing light at an electrode, ECL represents a marriage between electrochemical and spectroscopic methods. This gives ECL many distinct advantages over other spectroscopy-based detection systems. For example, ECL do not involve a light source as fluorescence methods do; thus, the attendant problems of scattered light and luminescent impurities are absent without the presence of a background signal. Moreover, the specificity of the ECL reaction associated with the ECL label and the coreactant species decreases problems with side reactions, such as self-quenching.

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Authors and Affiliations

  1. Nanjing University, Nanjing, P.R. China

    Huangxian Ju

  2. World Precision Instruments, Inc., Sarasota, FL, USA

    Xueji Zhang

  3. University of Science & Technology, Beijing, P.R. China

    Xueji Zhang

  4. University of California, San Diego, CA, USA

    Joseph Wang

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  1. Huangxian Ju
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  2. Xueji Zhang
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Correspondence to Huangxian Ju .

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Ju, H., Zhang, X., Wang, J. (2011). Biosensing with Nanoparticles as Electrogenerated Chemiluminsecence Emitters. In: NanoBiosensing. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9622-0_8

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