NanoBiosensing pp 485-534 | Cite as

Cytosensing and Cell Surface Carbohydrate Assay by Assembly of Nanoparticles

Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)


Cells are the basic units of life. All organisms are made up of cells. Thus, developing sensing platforms for probing the chemistry and physics in or at a living cell is one of the basic goals in understanding the intricate processes that ultimately contribute to life and life processes. Moreover, in the field of medicine, each cell type has a unique molecular signature that distinguishes between healthy and diseased tissues [1]. Cancerous cells are differentiated from noncancerous ones on the basis of ­intracellular or extracellular (cell surface) biomarkers. In most cases, the distinctions between normal vs. tumor and benign vs. metastatic cells are often subtle. Thus, the identification of cellular signatures for early cancer cell detection is a major hurdle for cancer therapy. The earlier these signatures can be established, the more effectively they can be treated [2]. In this regard, technological systems that provide sensors with high sensitivity, selectivity, and stability are in high demand to identify the unique cellular characteristics such as proteins and nucleic acids in and on living cells at early disease states, providing the prospects of better health and more effective therapy [3].


Cell Surface Carbohydrate Electrochemical Impedance Spectroscopic Cell Surface Glycan SERS Label Electrochemical Impedance Spectroscopic Measurement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Nanjing UniversityNanjingP.R. China
  2. 2.World Precision Instruments, Inc.SarasotaUSA
  3. 3.University of Science & TechnologyBeijingP.R. China
  4. 4.University of CaliforniaSan DiegoUSA

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