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Kainate Receptors pp 69–80Cite as

Metabotropic Actions of Kainate Receptors in Dorsal Root Ganglion Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 717))

Abstract

Kainate receptors are widely distributed in the CNS, but also in the PNS. Dorsal root ganglia are enriched in this subtype of glutamate ionotropic receptors. In addition to their activity as ligand-gated ion channels, kainate receptors exhibit other properties already characterized in other systems, such as hippocampus, i.e., their ability to induce a metabotropic cascade signalling, through G-protein and PKC activation. With a very similar actuation mechanism as formerly described in the CNS, kainate receptors in the DRG also present other differentiated features, such as the Ca2+ channel blockade and a self-regulation property. The peculiarity of these neurons has served to progress the study of kainate receptors. Nevertheless, many other physiological functions of these receptors remain unclear, as does the related molecular nature of the metabotropic cascade and the involvement of this signalling pathway with sensory transmission of pain.

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Authors and Affiliations

  1. Institute de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain

    Jose Luis Rozas

  2. Dpto. Fisiologfía Médica y Biofísíca, Universidad de Sevilla and Centra de Investigation Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Sevilla, Spain

    Jose Luis Rozas

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  1. Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain

    Antonio Rodríguez-Moreno PhD

  2. Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK

    Talvinder S. Sihra PhD

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Rozas, J.L. (2011). Metabotropic Actions of Kainate Receptors in Dorsal Root Ganglion Cells. In: Rodríguez-Moreno, A., Sihra, T.S. (eds) Kainate Receptors. Advances in Experimental Medicine and Biology, vol 717. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9557-5_7

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