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Down-Regulation of Mast Cell Responses through ITIM Containing Inhibitory Receptors

  • Chapter
Mast Cell Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 716))

Abstract

The multiple cell types that comprise the immune system provide an efficient defense system against invading pathogens and micro-organisms. In general, immune cells are activated for disparate functions, such as proliferation, production and release of mediators and chemotaxis, as a result of interactions between ligands and their matching immunoreceptors. This in turn leads to the recruitment and activation of a cascade of second messengers, via their regulators/adaptors, that determine the net effect of the initial response. However, activation of cells of the immune system must be tightly regulated by a finely tuned interplay between activation and inhibition to avoid excessive or inappropriate responsiveness and to maintain homeostasis. Loss of inhibitory signals may disrupt this balance, leading to various pathological processes such as allergic and auto-immune diseases. In this chapter, we will discuss down-regulating mechanisms of mast cells focusing on immunoreceptor tyrosine-based inhibition motifs (ITIM)-containing inhibitory receptors (IR).

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Authors and Affiliations

  1. Department of Pharmacology and Experimental Therapeutics, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

    Laila Karra & Francesca Levi-Schaffer

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  1. Laila Karra
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  2. Francesca Levi-Schaffer
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  1. Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    Alasdair M. Gilfillan PhD  & Dean D. Metcalfe MD  & 

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Karra, L., Levi-Schaffer, F. (2011). Down-Regulation of Mast Cell Responses through ITIM Containing Inhibitory Receptors. In: Gilfillan, A.M., Metcalfe, D.D. (eds) Mast Cell Biology. Advances in Experimental Medicine and Biology, vol 716. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9533-9_9

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