Monomeric IgE and Mast Cell Development, Survival and Function

  • Jun-ichi Kashiwakura
  • Iris M. Otani
  • Toshiaki Kawakami
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 716)


Mast cells play a major role in allergy and anaphylaxis, as well as a protective role in immunity against bacteria and venoms (innate immunity) and T-cell activation (acquired immunity).1,2 It was long thought that two steps are essential to mast cell activation. The first step (sensitization) occurs when antigen-specific IgE binds to its high-affinity IgE receptor (FcεRI) expressed on the surface of mast cells. The second step occurs when antigen (Ag) or anti-IgE binds antigen-specific IgE antibodies bound to FcεRI present on the mast cell surface (this mode of stimulation hereafter referred to as IgE+Ag or IgE+anti-IgE stimulation, respectively).

Conventional wisdom has been that monomeric IgE plays only an initial, passive role in mast cell activation. However, recent findings have shown that IgE binding to its receptor FcεRI can mediate mast cell activation events even in the absence of antigen (this mode of stimulation hereafter referred to as IgE(-Ag) stimulation). Different subtypes of monomeric IgEs act via IgE(-Ag) stimulation to elicit varied effects on mast cells function, survival and differentiation. This chapter will describe the role of monomeric IgE molecules in allergic reaction, the various effects and mechanisms of action of IgE(-Ag) stimulation on mast cells and what possible developments may arise from this knowledge in the future. Since mast cells are involved in a variety of pathologic and protective responses, understanding the role that monomeric IgE plays in mast cell function, survival and differentiation will hopefully lead to better understanding and treatment of asthma and other allergic diseases, as well as improved understanding of host response to infections.


Mast Cell Lipid Raft Mouse Mast Cell Mast Cell Function Induce Mast Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Galli SJ, Maurer M, Lantz CS. Mast cells as sentinels of innate immunity. Curr Opin Immunol 1999; 11(1):53–59.PubMedGoogle Scholar
  2. 2.
    Metcalfe DD, Baram D, Mekori YA. Mast cells. Physiol Rev 1997; 77(4):1033–1079.Google Scholar
  3. 3.
    Gupta R, Sheikh A, Strachan DP, Anderson HR. Burden of allergic disease in the UK: secondary analyses of national databases. Clin Exp Allergy 2004; 34(4):520–526.PubMedGoogle Scholar
  4. 4.
    Kawakami T. A crucial door to the mast cell mystery knocked in. J Immunol 2009; 183(11):6861–6862.PubMedGoogle Scholar
  5. 5.
    Galli SJ, Nakae S, Tsai M. Mast cells in the development of adaptive immune responses. Nat Immunol 2005; 6(2):135–142.PubMedGoogle Scholar
  6. 6.
    Wedemeyer J, Tsai M, Galli SJ. Roles of mast cells and basophils in innate and acquired immunity. Curr Opin Immunol 2000; 12(6):624–631.PubMedGoogle Scholar
  7. 7.
    Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol 2008; 8(3):205–217.PubMedGoogle Scholar
  8. 8.
    Geha RS, Jabara HH, Brodeur SR. The regulation of immunoglobulin E class-switch recombination. Nat Rev Immunol 2003;3(9):721–732.PubMedGoogle Scholar
  9. 9.
    Barnes PJ. Anti-IgE therapy in asthma: rationale and therapeutic potential. Int Arch Allergy Immunol 2000; 123(3):196–204.PubMedGoogle Scholar
  10. 10.
    Kinet JP. The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu Rev Immunol 1999; 17:931–972.PubMedGoogle Scholar
  11. 11.
    Cambier JC. Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J Immunol 1995; 155(7):3281–3285.PubMedGoogle Scholar
  12. 12.
    Parravicini V, Gadina M, Kovarova M et al. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol 2002; 3(8):741–748.PubMedGoogle Scholar
  13. 13.
    Turner H, Kinet JP. Signalling through the high-affinity IgE receptor Fc epsilonRI. Nature 1999; 402(6760 Suppl):B24–30.PubMedGoogle Scholar
  14. 14.
    Kawakami T, Galli SJ. Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol 2002; 2(10):773–786.PubMedGoogle Scholar
  15. 15.
    Furuichi K, Rivera J, Isersky C. The receptor for immunoglobulin E on rat basophilic leukemia cells: effect of ligand binding on receptor expression. Proc Natl Acad Sci USA 1985; 82(5):1522–1525.PubMedGoogle Scholar
  16. 16.
    Hsu C, MacGlashan D, Jr. IgE antibody up-regulates high affinity IgE binding on murine bone marrow-derived mast cells. Immunol Lett 1996; 52(2–3):129–134.PubMedGoogle Scholar
  17. 17.
    Yamaguchi M, Lantz CS, Oettgen HC et al. IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med 1997; 185(4):663–672.PubMedGoogle Scholar
  18. 18.
    Asai K, Kitaura J, Kawakami Y et al. Regulation of mast cell survival by IgE. Immunity 2001; 14(6):791–800.PubMedGoogle Scholar
  19. 19.
    Eshhar Z, Ofarim M, Waks T. Generation of hybridomas secreting murine reaginic antibodies of anti-DNP specificity. J Immunol 1980; 124(2):775–780.PubMedGoogle Scholar
  20. 20.
    Tanaka S, Takasu Y, Mikura S et al. Antigen-independent induction of histamine synthesis by immunoglobulin E in mouse bone marrow-derived mast cells. J Exp Med 2002; 196(2):229–235.PubMedGoogle Scholar
  21. 21.
    Kitaura J, Song J, Tsai M et al. Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci USA 2003; 100(22):12911–12916.PubMedGoogle Scholar
  22. 22.
    Yamada N, Matsushima H, Tagaya Y et al. Generation of a large number of connective tissue type mast cells by culture of murine fetal skin cells. J Invest Dermatol 2003; 121(6):1425–1432.PubMedGoogle Scholar
  23. 23.
    Oka T, Hori M, Tanaka A et al. IgE alone-induced actin assembly modifies calcium signaling and degranulation in RBL-2H3 mast cells. Am J Physiol Cell Physiol 2004; 286(2):C256–263.PubMedGoogle Scholar
  24. 24.
    Pandey V, Mihara S, Fensome-Green A et al. Monomeric IgE stimulates NFAT translocation into the nucleus, a rise in cytosol Ca2+, degranulation and membrane ruffling in the cultured rat basophilic leukemia-2H3 mast cell line. J Immunol 2004; 172(7):4048–4058.PubMedGoogle Scholar
  25. 25.
    Lam V, Kalesnikoff J, Lee CW et al. IgE alone stimulates mast cell adhesion to fibronectin via pathways similar to those used by IgE + antigen but distinct from those used by Steel factor. Blood 2003; 102(4): 1405–1413.PubMedGoogle Scholar
  26. 26.
    Kitaura J, Kinoshita T, Matsumoto M et al. IgE-and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion. Blood 2005; 105(8):3222–3229.PubMedGoogle Scholar
  27. 27.
    Kalesnikoff J, Huber M, Lam V et al. Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity 2001; 14(6):801–811.PubMedGoogle Scholar
  28. 28.
    Kawakami T, Kitaura J. Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance. J Immunol 2005; 175(7):4167–4173.PubMedGoogle Scholar
  29. 29.
    Kitaura J, Eto K, Kinoshita T et al. Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec and protein kinase C family kinases. J Immunol 2005; 174(8):4495–4504.PubMedGoogle Scholar
  30. 30.
    Strober W. Immunology: The expanding T(H)2 universe. Nature 2010; 463(7280):434–435.PubMedGoogle Scholar
  31. 31.
    Packard KA, Khan MM. Effects of histamine on Th1/Th2 cytokine balance. Int Immunopharmacol 2003; 3(7):909–920.PubMedGoogle Scholar
  32. 32.
    Goodarzi K, Goodarzi M, Tager AM et al. Leukotriene B4 and BLT1 control cytotoxic effector T-cell recruitment to inflamed tissues. Nat Immunol 2003; 4(10):965–973.PubMedGoogle Scholar
  33. 33.
    Ott VL, Cambier JC, Kappler J et al. Mast cell-dependent migration of effector CD8+ T-cells through production of leukotriene B4. Nat Immunol 2003; 4(10):974–981.PubMedGoogle Scholar
  34. 34.
    Tager AM, Bromley SK, Medoff BD et al. Leukotriene B4 receptor BLT1 mediates early effector T-cell recruitment. Nat Immunol 2003; 4(10):982–990.PubMedGoogle Scholar
  35. 35.
    Makhija R, Kingsnorth AN. Cytokine storm in acute pancreatitis. J Hepatobiliary Pancreat Surg 2002; 9(4):401–410.PubMedGoogle Scholar
  36. 36.
    Nakajima T, Inagaki N, Tanaka H et al. Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparison. Blood 2002; 100(12):3861–3868.PubMedGoogle Scholar
  37. 37.
    Laffargue M, Calvez R, Finan P et al. Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function. Immunity 2002; 16(3):441–451.PubMedGoogle Scholar
  38. 38.
    Jolly PS, Bektas M, Olivera A et al. Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med 2004; 199(7):959–970.PubMedGoogle Scholar
  39. 39.
    Matsuda K, Piliponsky AM, Iikura M et al. Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response. J Allergy Clin Immunol 2005; 116(6):1357–1363.PubMedGoogle Scholar
  40. 40.
    Cruse G, Kaur D, Yang W et al. Activation of human lung mast cells by monomeric immunoglobulin E. Eur Respir J 2005; 25(5):858–863.PubMedGoogle Scholar
  41. 41.
    Gilchrest H, Cheewatrakoolpong B, Billah M et al. Human cord blood-derived mast cells synthesize and release 1-309 in response to IgE. Life Sci 2003; 73(20):2571–2581.PubMedGoogle Scholar
  42. 42.
    Borkowski TA, Jouvin MH, Lin SY et al. Minimal requirements for IgE-mediated regulation of surface Fc epsilon RI. J Immunol 2001; 167(3): 1290–1296.PubMedGoogle Scholar
  43. 43.
    Kubo S, Matsuoka K, Taya C et al. Drastic up-regulation of Fcepsilonri on mast cells is induced by IgE binding through stabilization and accumulation of Fcepsilonri on the cell surface. J Immunol 2001; 167(6):3427–3434.PubMedGoogle Scholar
  44. 44.
    Kitaura J, Xiao W, Maeda-Yamamoto M et al. Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production and survival. J Immunol 2004; 173(7):4317–4323.PubMedGoogle Scholar
  45. 45.
    Jayapal M, Tay HK, Reghunathan R et al. Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcepsilonRI-aggregation reveals acomplex network of genes involved in inflammatory responses. BMC Genomics 2006; 7:210.PubMedGoogle Scholar
  46. 46.
    Yip KH, Huang Y, Waye MM et al. Induction of nitric oxide synthases in primary human cultured mast cells by IgE and proinflammatory cytokines. Int Immunopharmacol 2008; 8(5):764–768.PubMedGoogle Scholar
  47. 47.
    Nevin BJ, Broadley KJ. Nitric oxide in respiratory diseases. Pharmacol Ther 2002; 95(3):259–293.PubMedGoogle Scholar
  48. 48.
    Fischer A, Folkerts G, Geppetti P et al. Mediators of asthma: nitric oxide. Pulm Pharmacol Ther 2002; 15(2):73–81.PubMedGoogle Scholar
  49. 49.
    Watanabe M, Satoh T, Yamamoto Y et al. Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils. J Immunol 2008; 181(8):5653–5659.PubMedGoogle Scholar
  50. 50.
    Saffar AS, Alphonse MP, Shan L et al. IgE modulates neutrophil survival in asthma: role of mitochondrial pathway. J Immunol 2007; 178(4):2535–2541.PubMedGoogle Scholar
  51. 51.
    Rowland SL, Depersis CL, Torres RM et al. Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B-cell differentiation. J Exp Med 2010.Google Scholar
  52. 52.
    Kawakami Y, Kitaura J, Yao L et al. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci USA 2003; 100(16):9470–9475.PubMedGoogle Scholar
  53. 53.
    Blank U, Cyprien B, Martin-Verdeaux S et al. SNAREs and associated regulators in the control of exocytosis in the RBL-2H3 mast cell line. Mol Immunol 2002; 38(16–18):1341–1345.PubMedGoogle Scholar
  54. 54.
    Puri N, Roche PA. Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis. Traffic 2006; 7(11): 1482–1494.PubMedGoogle Scholar
  55. 55.
    Kashiwakura J, Xiao W, Kitaura J et al. Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype. J Leukoc Biol 2008; 84(2):357–367.PubMedGoogle Scholar
  56. 56.
    Liu FT, Bonn JW, Ferry EL et al. Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation and characterization. J Immunol 1980; 124(6):2728–2737.PubMedGoogle Scholar
  57. 57.
    MacDonald SM, Lichtenstein LM, Proud D et al. Studies of IgE-dependent histamine releasing factors: heterogeneity of IgE. J Immunol 1987; 139(2):506–512.PubMedGoogle Scholar
  58. 58.
    Schroeder JT, Lichtenstein LM, MacDonald SM. An immunoglobulin E-dependent recombinant histamine-releasing factor induces interleukin-4 secretion from human basophils. J Exp Med 1996; 183(3):1265–1270.PubMedGoogle Scholar
  59. 59.
    Gould HJ, Sutton BJ, Beavil AJ et al. The biology of IGE and the basis of allergic disease. Annu Rev Immunol 2003; 21:579–628.PubMedGoogle Scholar
  60. 60.
    Beaven MA, Metzger H. Signal transduction by Fc receptors: the Fc epsilon RI case. Immunol Today 1993; 14(5):222–226.PubMedGoogle Scholar
  61. 61.
    Ullrich A, Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990; 61(2):203–212.PubMedGoogle Scholar
  62. 62.
    Heldin CH. Dimerization of cell surface receptors in signal transduction. Cell 1995; 80(2):213–223.PubMedGoogle Scholar
  63. 63.
    Field KA, Holowka D, Baird B. Fc epsilon RI-mediated recruitment of p53/561yn to detergent-resistant membrane domains accompanies cellular signaling. Proc Natl Acad Sci USA 1995; 92(20):9201–9205.PubMedGoogle Scholar
  64. 64.
    Field KA, Holowka D, Baird B. Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains. J Biol Chem 1997; 272(7):4276–4280.PubMedGoogle Scholar
  65. 65.
    James LC, Roversi P, Tawfik DS. Antibody multispecificity mediated by conformational diversity. Science 2003; 299(5611):1362–1367.PubMedGoogle Scholar
  66. 66.
    Schramm G, Mohrs K, Wodrich M et al. Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo. J Immunol 2007; 178(10):6023–6027.Google Scholar
  67. 67.
    Charles N, Monteiro RC, Benhamou M. p28, a novel IgE receptor-associated protein, is a sensor of receptor occupation by its ligand in mast cells. J Biol Chem 2004; 279(13):12312–12318.PubMedGoogle Scholar
  68. 68.
    Jayawardana ST, Ushio H, Niyonsaba F et al. Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis. Biochem Biophys Res Commun 2008; 365(1): 137–142.PubMedGoogle Scholar
  69. 69.
    Kohno M, Yamasaki S, Tybulewicz VL et al. Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen. Blood 2005; 105(5):2059–2065.PubMedGoogle Scholar
  70. 70.
    Shelburne CP, McCoy ME, Piekorz R et al. Stat5 expression is critical for mast cell development and survival. Blood 2003; 102(4):1290–1297.PubMedGoogle Scholar
  71. 71.
    Sly LM, Kalesnikoff J, Lam V et al. IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species. J Immunol 2008; 181(6):3850–3860.Google Scholar
  72. 72.
    Yanagida M, Fukamachi H, Ohgami K et al. Effects of T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5 and IL-6 on the survival of cultured human mast cells. Blood 1995; 86(10):3705–3714.PubMedGoogle Scholar
  73. 73.
    Oskeritzian CA, Zhao W, Pozez AL et al. Neutralizing endogenous IL-6 renders mast cells of the MCT type from lung, but not the MCTC type from skin and lung, susceptible to human recombinant IL-4-induced apoptosis. J Immunol 2004; 172(1):593–600.PubMedGoogle Scholar
  74. 74.
    Takenaka H, Ushio H, Niyonsaba F et al. Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands. Biochem Biophys Res Commun 2010; 391(1):471–476.PubMedGoogle Scholar
  75. 75.
    Yoshikawa H, Nakajima Y, Tasaka K. Glucocorticoid suppresses autocrine survival of mast cells by inhibiting IL-4 production and ICAM-1 expression. J Immunol 1999; 162(10):6162–6170.PubMedGoogle Scholar
  76. 76.
    Yoshikawa H, Nakajima Y, Tasaka K. Enhanced expression of Fas-associated death domain-like IL-1-converting enzyme (FLICE)-inhibitory protein induces resistance to Fas-mediated apoptosis in activated mast cells. J Immunol 2000; 165(11):6262–6269.PubMedGoogle Scholar
  77. 77.
    Alfredsson J, Puthalakath H, Martin H et al. Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation. Cell Death Differ 2005; 12(2): 136–144.PubMedGoogle Scholar
  78. 78.
    Rivera J, Gilfillan AM. Molecular regulation of mast cell activation. J Allergy Clin Immunol 2006; 117(6):1214–1225PubMedGoogle Scholar
  79. 79.
    Malbec O, Malissen M, Isnardi I et al. Linker for activation of T-cells integrates positive and negative signaling in mast cells. J Immunol 2004; 173(8):5086–5094.PubMedGoogle Scholar
  80. 80.
    Nunomura S, Gon Y, Yoshimaru T et al. Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE. Int Immunol 2005; 17(6):685–694.PubMedGoogle Scholar
  81. 81.
    Kawakami Y, Kitaura J, Hartman SE et al. Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. Proc Natl Acad Sci USA 2000; 97(13):7423–7428.PubMedGoogle Scholar
  82. 82.
    Liu Y, Furuta K, Teshima R et al. Critical role of protein kinase C betaII in activation of mast cells by monomeric IgE. J Biol Chem 2005; 280(47):38976–38981.PubMedGoogle Scholar
  83. 83.
    Yamasaki S, Saito T. Progress in allergy signal research on mast cells: signal regulation of multiple mast cell responses through FcepsilonRI. J Pharmacol Sci 2008; 106(3):336–340.PubMedGoogle Scholar
  84. 84.
    Sakurai D, Yamasaki S, Arase K et al. Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J Immunol 2004; 172(4):2374–2381.PubMedGoogle Scholar
  85. 85.
    Yamasaki S, Ishikawa E, Kohno M et al. The quantity and duration of FcRgamma signals determine mast cell degranulation and survival. Blood 2004; 103(8):3093–3101.PubMedGoogle Scholar
  86. 86.
    Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995; 80(2):179–185.PubMedGoogle Scholar
  87. 87.
    Werlen G, Hausmann B, Naeher D et al. Signaling life and death in the thymus: timing is everything. Science 2003; 299(5614):1859–1863.PubMedGoogle Scholar
  88. 88.
    Yamasaki S, Ishikawa E, Sakuma M et al. LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival. Mol Cell Biol 2007; 27(12):4406–4415.PubMedGoogle Scholar
  89. 89.
    Yamasaki S, Takase-Utsugi M, Ishikawa E et al. Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice. Int Immunol 2008; 20(10):1289–1297.PubMedGoogle Scholar
  90. 90.
    Tanaka S, Mikura S, Hashimoto E et al. Ca2+ influx-mediated histamine synthesis and IL-6 release in mast cells activated by monomeric IgE. Eur J Immunol 2005; 35(2):460–468.PubMedGoogle Scholar
  91. 91.
    Matsuoka K, Taya C, Kubo S et al. Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivo. Int Immunol 1999; 11(6):987–994.PubMedGoogle Scholar
  92. 92.
    Oettgen HC, Martin TR, Wynshaw-Boris A et al. Active anaphylaxis in IgE-deficient mice. Nature 1994; 370(6488):367–370.PubMedGoogle Scholar
  93. 93.
    Gurish MF, Bryce PJ, Tao H et al. IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis. J Immunol 2004; 172(2): 1139–1145.PubMedGoogle Scholar
  94. 94.
    Lantz CS, Boesiger J, Song CH et al. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature 1998; 392(6671):90–93.PubMedGoogle Scholar
  95. 95.
    Matsuda H, Watanabe N, Geba GP et al. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int Immunol 1997; 9(3):461–466.PubMedGoogle Scholar
  96. 96.
    Pritchard DI, Hewitt C, Moqbel R. The relationship between immunological responsiveness controlled by T-helper 2 lymphocytes and infections with parasitic helminths. Parasitology 1997; 115 Suppl:S33–S44.Google Scholar
  97. 97.
    Bryce PJ, Miller ML, Miyajima I et al. Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Immunity 2004; 20(4):381–392.PubMedGoogle Scholar
  98. 98.
    Mathias CB, Freyschmidt EJ, Caplan B et al. IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation. J Immunol 2009; 182(4):2416–2424.PubMedGoogle Scholar
  99. 99.
    Kitamura Y, Ito A. Mast cell-committed progenitors. Proc Natl Acad Sci USA 2005; 102(32):11129–11130.PubMedGoogle Scholar
  100. 100.
    Kitamura Y, Shimada M, Hatanaka K et al. Development of mast cells from grafted bone marrow cells in irradiated mice. Nature 1977; 268(5619):442–443.PubMedGoogle Scholar
  101. 101.
    Nabel G, Galli SJ, Dvorak AM et al. InducerT-lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells. Nature 1981; 291(5813):332–334.PubMedGoogle Scholar
  102. 102.
    Galli SJ, Zsebo KM, Geissler EN. The kit ligand, stem cell factor. Adv Immunol 1994; 55:1–96.PubMedGoogle Scholar
  103. 103.
    Okayama Y, Kawakami T. Development, migration and survival of mast cells. Immunol Res 2006; 34(2):97–115.PubMedGoogle Scholar
  104. 104.
    Barrett EL, Clark MA. Tetrathionate reduction and production of hydrogen sulfide from thiosulfate. Microbiol Rev 1987; 51(2):192–205.PubMedGoogle Scholar
  105. 105.
    Bienenstock J, Befus AD, Pearce F et al. Mast cell heterogeneity: derivation and function, with emphasis on the intestine. J Allergy Clin Immunol 1982; 70(6):407–412.PubMedGoogle Scholar
  106. 106.
    McNeil HP, Austen KF, Somerville LL et al. Molecular cloning of the mouse mast cell protease-5 gene. A novel secretory granule protease expressed early in the differentiation of serosal mast cells. J Biol Chem 1991; 266(30):20316–20322.PubMedGoogle Scholar
  107. 107.
    Reynolds DS, Gurley DS, Austen KF et al. Cloning of the cDNA and gene of mouse mast cell protease-6. Transcription by progenitor mast cells and mast cells of the connective tissue subclass. J Biol Chem 1991; 266(6):3847–3853.PubMedGoogle Scholar
  108. 108.
    Reynolds DS, Stevens RL, Gurley DS et al. Isolation and molecular cloning of mast cell carboxypeptidase A. A novel member of the carboxypeptidase gene family. J Biol Chem 1989; 264(33):20094–20099.PubMedGoogle Scholar
  109. 109.
    Serafin WE, Reynolds DS, Rogelj S et al. Identification and molecular cloning of a novel mouse mucosal mast cell serine protease. J Biol Chem 1990; 265(1):423–429.PubMedGoogle Scholar
  110. 110.
    Serafin WE, Sullivan TP, Conder GA et al. Cloning of the cDNA and gene for mouse mast cell protease 4. Demonstration of its late transcription in mast cell subclasses and analysis of its homology to subclass-specific neutral proteases of the mouse and rat. J Biol Chem 1991; 266(3):1934–1941.PubMedGoogle Scholar
  111. 111.
    Trong HL, Newlands GF, Miller HR et al. Amino acid sequence of a mouse mucosal mast cell protease. Biochemistry 1989; 28(1):391–395.PubMedGoogle Scholar
  112. 112.
    Wright HV, Bailey D, Kashyap M et al. IL-3-mediated TNF production is necessary for mast cell development. J Immunol 2006; 176(4):2114–2121.PubMedGoogle Scholar
  113. 113.
    Kawakami Y, Yumoto K, Kawakami T. An improved mouse model of atopic dermatitis and suppression of skin lesions by an inhibitor of Tec family kinases. Allergol Int 2007; 56(4):403–409.PubMedGoogle Scholar
  114. 114.
    Kawakami Y, Tomimori Y, Yumoto K et al. Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum. J Exp Med 2009; 206(6):1219–1225.PubMedGoogle Scholar
  115. 115.
    Kashiwakura J, Kawakami Y, Yuki K et al. Polyclonal IgE induces mast cell survival and cytokine production. Allergol Int 2009; 58(3):411–419.PubMedGoogle Scholar

Copyright information

© Landes Bioscience and Springer Science+Business Media 2011

Authors and Affiliations

  • Jun-ichi Kashiwakura
    • 1
  • Iris M. Otani
    • 1
  • Toshiaki Kawakami
    • 1
  1. 1.Division of Cell BiologyLa Jolla Institute for Allergy and ImmunologyLa JollaUSA

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