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Caspase-Independent Stroke Targets

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Translational Stroke Research

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Delayed neuronal death in the penumbral region of a stroke is largely responsible for many negative implications seen in stroke victims. This type of neuronal death occurs in many forms, including apoptosis, necrosis, and alternative mechanisms. Although caspases are usually associated with apoptosis, there are several morphologically and biochemically distinct types of cell death that are independent of caspase activation. Downstream effectors and processes of mitochondrial damage, such as AIF, endonuclease G, BNIP3, mitophagy, mitochondrial biogenesis, chaperone-mediated autophagy, reactive oxygen species production as well as parallel endoplasmic reticular stress and lysosomal dysfunction, have all been shown to play a role in post-stroke delayed neuronal cell death. In this chapter, we attempt to summarize these caspase-independent events and their potential therapeutic applications as targets for intervention.

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Acknowledgments

This work was supported by grants from the Canadian Institutes of Health Research, Canadian Stroke Network and Manitoba Health Research Council (to J. Kong). Dr. Jiming Kong received a salary award from the Heart and Stroke Foundation of Canada. Ms. Ruoyang Shi received a Manitoba Health Research Council/Manitoba Institute of Child Health Graduate Studentship.

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Authors and Affiliations

  1. Department of Human Anatomy and Cell Science, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, MB, Canada, R3E 0J9

    Ruoyang Shi, Jiequn Weng, Paul Szelemej & Jiming Kong

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  1. Ruoyang Shi
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  2. Jiequn Weng
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  3. Paul Szelemej
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  4. Jiming Kong
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Correspondence to Jiming Kong .

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  1. , Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA

    Paul A. Lapchak

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Shi, R., Weng, J., Szelemej, P., Kong, J. (2012). Caspase-Independent Stroke Targets. In: Lapchak, P., Zhang, J. (eds) Translational Stroke Research. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9530-8_7

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