Animal Models of Intracranial Aneurysms

  • Elena I. Liang
  • Hiroshi Makino
  • Yoshiteru Tada
  • Kosuke Wada
  • Tomoki Hashimoto
Chapter
Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Abstract

We established a new mouse model of intracranial aneurysms that yields large aneurysms within a relatively short time frame. Aneurysms are induced by a combination of pharmacological hypertension and a single injection of elastase into the cerebrospinal fluid. The model gives us a unique opportunity to study and understand the mechanisms for not only aneurysm formation but also the rupture of intracranial aneurysms. Using this model, we can study the effects of various pharmacological agents on aneurysmal rupture in mice and translate our findings toward the clinical setting.

Keywords

Angiotensin Deoxycorticosterone 

Notes

Acknowledgment

This study was funded by the National Institutes of Health (R01NS055876 P01NS04415, both TH), the American Heart Association (11GRNT6380003, TH), and The Brain Aneurysm Foundation (TH).

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Elena I. Liang
    • 1
  • Hiroshi Makino
    • 1
  • Yoshiteru Tada
    • 1
  • Kosuke Wada
    • 1
  • Tomoki Hashimoto
    • 1
  1. 1.Department of Anesthesia and Perioperative Care, Center for Cerebrovascular ResearchUniversity of CaliforniaSan FranciscoUSA

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