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The Splenic Response to Ischemic Stroke: Neuroinflammation, Immune Cell Migration, and Experimental Approaches to Defining Cellular Mechanisms

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Translational Stroke Research

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

The neural sequelae resulting from ischemic stroke involve multiple physiological systems resulting in acute injury followed by delayed cellular degeneration. Clinical studies targeting early neural injury uncovered in animal models of stroke have resulted in poor outcomes. The limited success of these approaches has broadened investigation into the delayed phase of infarct expansion, whereby the penumbral tissue surrounding the initial core infarct can be rescued prior to irreversible injury. Of particular relevance are the neuroimmune mechanisms that are activated from several hours to days following ischemic stroke and eventually lead to permanent infarction that cannot be rescued. New findings from animal studies suggest that the therapeutic window is wider than previously thought, thus allowing for selective targeting of inflammatory processes prior to irreversible injury.

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Authors and Affiliations

  1. College of Medicine, University of South Florida, Tampa, FL, USA

    Christopher C. Leonardo, Hilary Seifert & Keith R. Pennypacker

Authors
  1. Christopher C. Leonardo
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  2. Hilary Seifert
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  3. Keith R. Pennypacker
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Correspondence to Keith R. Pennypacker .

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Editors and Affiliations

  1. , Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA

    Paul A. Lapchak

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Leonardo, C.C., Seifert, H., Pennypacker, K.R. (2012). The Splenic Response to Ischemic Stroke: Neuroinflammation, Immune Cell Migration, and Experimental Approaches to Defining Cellular Mechanisms. In: Lapchak, P., Zhang, J. (eds) Translational Stroke Research. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9530-8_23

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