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Neuroglobin: A Novel Target for Endogenous Neuroprotection

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Translational Stroke Research

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

Abstract

Augmentation of endogenous protective mechanisms has been thought to be promising strategies to develop new therapies against stroke. Neuroglobin (Ngb) is a tissue oxygen-binding globin that is highly and specifically expressed in brain neurons. Accumulating evidences have proved Ngb is a unique endogenous neuroprotective molecule against hypoxic/ischemic insults in cultured neurons and in stroke animals, which strongly suggest that development of pharmacological strategies that upregulate endogenous Ngb expression may lead to a novel therapeutic approach for stroke intervention. In this chapter, recent experimental findings from our laboratory and others in understanding Ngb’s biological function, gene expression regulation, and neuroprotective mechanisms are summarized. We also propose strategies to identify small molecules that upregulate endogenous Ngb for neuroprotection against stroke and related neurological disorders. Briefly, the strategies comprise two translational features. First, we will establish both mouse and human Ngb gene activation reporter stable cell lines to ensure that only compounds capable of activating both mouse and human Ngb promoters will be selected for further testing. Second, validation is the key component of any single step in drug screening and therapeutic development processes.

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Authors and Affiliations

  1. Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2411A, Charlestown, MA, 02129, USA

    Zhanyang Yu, Ning Liu & Xiaoying Wang MD, PhD

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  1. Zhanyang Yu
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  2. Ning Liu
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  3. Xiaoying Wang MD, PhD
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Correspondence to Xiaoying Wang MD, PhD .

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Editors and Affiliations

  1. , Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA

    Paul A. Lapchak

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Yu, Z., Liu, N., Wang, X. (2012). Neuroglobin: A Novel Target for Endogenous Neuroprotection. In: Lapchak, P., Zhang, J. (eds) Translational Stroke Research. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9530-8_18

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