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Diagnosis and Multidisciplinary Treatment of Laryngeal Cancers

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Head and Neck Cancer

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Abstract

Laryngeal cancer is the second most common respiratory cancer after lung cancer. Most laryngeal squamous cell carcinomas result from prolonged exposure to carcinogens that stimulate mucosal hyperplasia and lead ultimately to carcinoma. The treatment of laryngeal cancer has evolved through several phases, initially with surgical resection, and evolving to multimodality nonsurgical approaches. Several novel nonsurgical approaches have emerged over the past decade. In this chapter, we will be discussing in depth the sequencing of nonsurgical therapies for advanced disease, the role of systemic therapy in general, and the development and approval of novel anticancer agents such as epidermal growth factor receptor and their use in combination with radiation or chemotherapy. In addition, we will touch on novel truly investigational approaches for highly selected patients and cover aspects related to staging and diagnosis, radiation and surgical techniques, as well as supportive care issues.

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Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA

    Fadlo R. Khuri

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  1. Nabil F. Saba
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  2. J. Trad Wadsworth
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  3. Jonathan J. Beitler
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Correspondence to Fadlo R. Khuri .

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    Jacques Bernier

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Saba, N.F., Wadsworth, J.T., Beitler, J.J., Khuri, F.R. (2011). Diagnosis and Multidisciplinary Treatment of Laryngeal Cancers. In: Bernier, J. (eds) Head and Neck Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9464-6_32

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