Whole Person Care and the Revolution in Genetics

  • David S. Rosenblatt
  • Jennifer FitzpatrickEmail author


Barton Childs, the great medical geneticist and teacher, provides a perspective on the role of genetics in medicine when he contrasts the approaches of two of the giants of medicine, William Osler and Archibald Garrod, both of whom held the position of regius professor of medicine at Oxford. Whereas the Oslerian world was one of a body ravaged by disease, the one that of Garrod was of an organism in balance with its environment. An individual with a given genetic endowment interacted with the environment to maintain or perturb homeostasis [1].


Genetics Medical genetics Genetic counseling Genetic testing Pharmacogenomics GWAS (genome-wide association studies) Choice Prevention PKU Down syndrome BRCA Huntington disease 


  1. 1.
    Childs B. The Metabolic and molecular basis of disease. Vol. 1: A logic of disease. 8th ed. New York, NY: McGraw-Hill; 2001.Google Scholar
  2. 2.
    Fraser FC. Genetic counseling. Am J Hum Genet. 1974;26:363–659.Google Scholar
  3. 3.
    Buckman R. How to break bad news. Toronto, ON: University of Toronto Press; 1998.Google Scholar
  4. 4.
    Kaplan M. SPIKES: a framework for breaking bad news to patients with cancer. Clin J Oncol Nurs. 2010;14(4):514–6.PubMedCrossRefGoogle Scholar
  5. 5.
    Kubler-Ross E. On death and dying. New York, NY: Simon & Schuster; 1970.Google Scholar
  6. 6.
    Cystic Fibrosis Foundation. Patient registry annual data report to the center directors. Bethesda, MD: CFF; 2008.
  7. 7.
    Elsas LJ II. Galactosemia. In: Pagon RA, Bird TC, Dolan CR, Stephens K, editors. GeneReviews (Internet). Seattle, WA: University of Washington. 4 Feb 1993–2000 (updated 27 Sep 2007).Google Scholar
  8. 8.
    Rolland JS, McDaniel SH. Beliefs and multicultural issues in the new era of genetics. In: Miller S, McDaniel S, Rolland J, Feetham S, editors. Individuals, families, and the new era of genetics: biopsychosocial perspectives. New York, NY: W. W. Norton; 2006.Google Scholar
  9. 9.
    Bernhardt C et al. Decreasing uptake of predictive testing for Huntington’s disease in a German centre: 12 years’ experience (1993–2004). Eur J Hum Genet. 2009;17(3):295–300.PubMedCrossRefGoogle Scholar
  10. 10.
    International Huntington Association and the World Federation of Neurology Research Group on Huntington’s Chorea. Guidelines for the molecular genetics predictive test in Huntington’s disease. J Med Genet. 1994;31(7):555–9.CrossRefGoogle Scholar
  11. 11.
    Beck M. Expecting Adam: a true story of birth, rebirth, and everyday magic. New York, NY: Berkley; 1999.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Program, Department of Human GeneticsMcGill UniversityMontrealCanada

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