Role of HIF-1 in Physiological Adaptation of the Carotid Body during Chronic Hypoxia
Chemoreceptors in the carotid body (CB) increase intracellular calcium and afferent nerve discharge in hypoxia and, thus, play an important role in the regulation of cardiorespiratory responses to hypoxia (see Gonzalez et al 1994 for review). Also, the CB plays a central role in the ventilatory acclimatization to hypoxia involving an initial rapid increase in ventilation followed by a progressive hyperventilation during hours and weeks of hypoxic exposure (see Bisgard, 2000; Lahiri et al 2001 for reviews). It is well known that the CB enlarges in human and animals living at high altitude or exposed to chronic hypoxia. The enlargement may be due to an increased vasculature, cellular hypertrophy and hyperplasia of the glomus cells in the CB (Dhillon et al. 1984; McGregor et al 1984; Bee et al 1986).
KeywordsVascular Endothelial Growth Factor Carotid Body Chronic Hypoxia Glomus Cell Hypoxic Ventilatory Response
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