Advertisement

Chemoreception pp 455-460 | Cite as

Cardiovascular and Respiratory Responses to Heme Oxygenase Inhibition in Conscious Rats

  • Haruhisa Hirakawa
  • Shigeru Oikawa
  • Vernon S. Bishop
  • Yoshiaki Hayashida
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 536)

Abstract

Many studies have indicated that endogenous carbon monoxide (CO) generated by the heme oxygenase (HO) system plays a physiological role as a second messenger (Maines, 1997). Although it has been suggested that the HO inhibitor-induced pressor response is mediated by the autonomic nervous system (Johnson et al. 1995), no direct evidence has been demonstrated by neural recordings. Furthermore, a recent study found that CO appears to modulate carotid body sensory activity (Prabhakar et al. 1995). However, the effect of HO inhibitor on tonic ventilatory regulation in conscious animals has not been examined. Accordingly, the main purpose of this study was to examine the respiratory response and the role of the autonomic nervous system in regulation of the cardiovascular response to the administration of zinc deuteroporphyrin 2, 4-bis glycol (ZnDPBG), an inhibitor of HO activity, in conscious rats. To assess the contribution of peripheral chemoreceptors (carotid and aortic bodies) to these responses, we also examined the effect of HO inhibition on respiration and the cardiovascular system in arterial chemo-denervated rats.

Keywords

Heme Oxygenase Mean Arterial Blood Pressure Carotid Body Respiratory Response Renal Sympathetic Nerve Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hirakawa, H., Nakamura, T., and Hayashida, Y., 1997, Effect of carbon dioxide on autonomic cardiovascular responses to systemic hypoxia in conscious rats. Am. J. Physiol. 273 (42): R747–R754.PubMedGoogle Scholar
  2. Johnson, R. A., Laversa, M., Askari, B., Abraham, N. G., and Nasjletti, A., 1995, A heme oxygenase product, presumably carbon monoxide, mediates a vasopressor function in rats. Hypertension 25: 166–169.PubMedCrossRefGoogle Scholar
  3. Maines, M. D., 1997, The heme oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 37: 517–554.PubMedCrossRefGoogle Scholar
  4. Prabhakar, N. R., Dinerman, J. L., Agani, F. H., and Snyder, S. H., 1995, Carbon monoxide: A role in carotid body chemoreception. Proc. Natl. Acad. Sci. 92: 1994–1997.PubMedCrossRefGoogle Scholar
  5. Verna, A., Roumy, M., and Leitner, L.-M, 1975, Loss of chemoreceptive properties of the rabbit carotid body after destruction of the glomus cells. Brain Res. 100: 13–23.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Haruhisa Hirakawa
    • 1
  • Shigeru Oikawa
    • 1
  • Vernon S. Bishop
    • 2
  • Yoshiaki Hayashida
    • 1
  1. 1.Department of Systems PhysiologyUniversity of Occupational and Environmental HealthFukuokaJapanJapan
  2. 2.Department of PhysiologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA

Personalised recommendations