Abstract
Myocarditis, particularly in children, remains a major cause of morbidity and mortality worldwide.1,2 Dilated cardiomyopathy (DCM) is the major reason for cardiac transplantation in the United States and Europe with an annual incidence of 2 to 8 cases per 100,000 and an estimated prevalence of 36 per 100,000.3 The idiopathic form of DCM accounts for approximately 50% of the patients undergoing transplantation. Each year in the United States over 750,000 cases of heart failure are reported,4 with approximately 250,000 deaths, and myocarditis or DCM probably account for 25% of these cases.5 At present the treatment of these conditions is limited to either management of the symptoms or transplantation and the cost is estimated at $3-4 billion/year. Therefore, understanding the basis for this disorder and developing both preventive and disease-specific therapies, would have a major impact on health care in the U.S. In this review we will describe some of the progress towards understanding the etiologies of these disorders in children, particularly that of adenoviruses, as well as progress towards clarification of the mechanisms of pathogenesis
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Towbin, J.A., Bowles, N.E. (2003). Diagnosis and Treatment of Myocarditis: The Role of Adenovirus Infection in Cardiomyopathy and Heart Failure. In: Matsumori, A. (eds) Cardiomyopathies and Heart Failure. Developments in Cardiovascular Medicine, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9264-2_26
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DOI: https://doi.org/10.1007/978-1-4419-9264-2_26
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