Molecular Detection and Characterization of Human Enteroviruses

  • Mark A. Pallansch
  • M. Steven Oberste
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 248)


Enteroviruses (family Picornaviridae) are among the most common of human viruses, infecting an estimated 50 million people annually in the United States and possibly a billion or more annually worldwide.1 2 Most infections are inapparent, but enteroviruses may cause a wide spectrum of acute disease, including mild upper respiratory illness (common cold), febrile rash (hand, foot, and mouth disease and herpangina), aseptic meningitis, pleurodynia, encephalitis, acute flaccid paralysis (paralytic poliomyelitis), and neonatal sepsis-like disease. Enterovirus infections result in 30,000 to 50,000 hospitalizations per year in the United States, with aseptic meningitis cases accounting for the vast majority of the hospitalizations. In addition to these acute illnesses, enteroviruses have also been associated with severe chronic diseases such as myocarditis,3 4 type 1 diabetes mellitus,5 and neuromuscular diseases.6


Acute Flaccid Paralysis Prototype Strain Enterovirus Infection Human Enterovirus Paralytic Poliomyelitis 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Mark A. Pallansch
    • 1
  • M. Steven Oberste
    • 1
  1. 1.Centers for Disease Control and PreventionAtlantaUSA

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