Development of Mast Cells: Process and Regulatory Mechanisms
Mast cells are progenies of the hematopoietic stem cell. Committed precursors of mast cells leave the bone marrow, migrate into the bloodstream, invade tissues, proliferate, then differentiate into mast cells. They can further proliferate after maturation, even after degranulation, and recover their original morphology. While basophils are also progenies of the hematopoietic stem, their process of differentiation is different from that of mast cells, and they ultimately differentiate within the bone marrow. Mature basophils cannot proliferate, and simply die after degranulation.
KeywordsMast Cell Stem Cell Factor Tryptophan Hydroxylase Subtraction Library Culture Mast Cell
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