Development of Mast Cells: Process and Regulatory Mechanisms

  • Yukihiko Kitamura
  • Eiichi Morii
  • Tomoko Jippo
  • Akihiko Ito
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 248)


Mast cells are progenies of the hematopoietic stem cell. Committed precursors of mast cells leave the bone marrow, migrate into the bloodstream, invade tissues, proliferate, then differentiate into mast cells. They can further proliferate after maturation, even after degranulation, and recover their original morphology. While basophils are also progenies of the hematopoietic stem, their process of differentiation is different from that of mast cells, and they ultimately differentiate within the bone marrow. Mature basophils cannot proliferate, and simply die after degranulation.


Mast Cell Stem Cell Factor Tryptophan Hydroxylase Subtraction Library Culture Mast Cell 
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  1. 1.
    1. Ebi Y, Kasugai T, Seino Y, et al. Mechanism of Mast Cell Deficiency in Mutant Mice of mi/mi Genotype: An Analysis by Co-Culture of Mast Cells and Fibroblasts. Blood 1990;75:1247–1251.PubMedGoogle Scholar
  2. 2.
    2. Ebi Y, Kanakura Y, Jippo-Kanemoto T, et al. Low c-kit Expression of Cultured Mast Cells of mi/mi Genotype may be Involved in Their Defective Responses to Fibroblasts that Express the Ligand for c-kit. Blood 1992;80:1454–1462.PubMedGoogle Scholar
  3. 3.
    Hertwig P. Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm-u, VererbLehre. 1942;80:220–246.Google Scholar
  4. 4.
    Hodgkinson CA, Moore KJ, Nakayama A, et al. Mutations at the Mouse Microphthalmia Locus are Associated with Defects in a Gene Encoding a Novel Basic-Helix-Loop-Helix-Zipper Protein. Cell 1993;74:395–404.PubMedCrossRefGoogle Scholar
  5. 5.
    Isozaki K, Tsujimura T, Nomura S, et al. Cell Type-Specific Deficiency of c-kit Gene Expression in Mutant mi/mi Genotype. Am J Pathol 1994;145:827–836.PubMedGoogle Scholar
  6. 6.
    Ito A, Morii E, Maeyama E, et al. Systematic Method to Obtain Novel Genes that are Regulated by mi Transcription Factor (MITF): Impaired Expression of Granzyme B and Tryptophan Hydroxylase in mi/mi Cultured Mast Cells. Blood 1998;91:3210–3221.PubMedGoogle Scholar
  7. 7.
    Ito A, Morii E, Kim DK, et al. Inhibitory Effect of the Transcription Factor Encoded by the mi Mutant Allele in Cultured Mast Cells of Mice. Blood 1999;93:1189–1196.PubMedGoogle Scholar
  8. 8.
    Jippo T, Lee YM, Katsu Y, et al. Deficient Transcription of Mouse Mast Cell Protease 4 Gene in Mutant Mice of mi/mi Genotype. Blood 1999;93:1942–1950.PubMedGoogle Scholar
  9. 9.
    Kim DK, Morii E, Ogihara H, et al. Different Effect of Various Mutant MITF Encoded by mi, mior, or Miwh Allele on Phenotype of Murine Mast Cells. Blood 1999;93:4179–4186.PubMedGoogle Scholar
  10. 10.
    Morii E, Takebayashi K, Motohashi H, et al. Loss of DNA Binding Ability of the Transcription Factor Encoded by the Mutant mi Locus. Biochem Biophys Res Commun 1994;205:1299–1304.PubMedCrossRefGoogle Scholar
  11. 11.
    11. Morii E, Tsujimura T, Jippo T, et al. Regulation of Mouse Mast Cell Protease 6 Gene Expression by Transcription Factor Encoded by the mi Locus. Blood 1996;88:2488– 2494.PubMedGoogle Scholar
  12. 12.
    Morii E, Jippo T, Tsujimura T, et al. Abnormal Expression of Mouse Mast Cell Protease 5 Gene in Cultured Mast Cells Derived from Mutant mi/mi Mice. Blood 1997;90:3057–3066.PubMedGoogle Scholar
  13. 13.
    Morii E, Ogihara H, Oboki K, et al. Effect of a Large Deletion of the Basic Domain of mi Transcription Factor on Differentiation of Mast Cells. Blood 2001 ; 98:2577–2579.PubMedCrossRefGoogle Scholar
  14. 14.
    Morii E, Ogihara H, Kim DK, et al. Importance of Leucine Zipper Domain of mi Transcription Factor (MITF) for Differentiation of Mast Cells Demonstrated Using mi ce /mi ce Mutant Mice of which MITF Lacks the Zipper Domain. Blood 2001;97:2038–2044.PubMedCrossRefGoogle Scholar
  15. 15.
    Ogihara H, Morii E, Kim DK, et al. Inhibitory Effect of Transcription Factor Encoded by Mutant mi Microphthalmia Allele on Transactivation of Mouse Mast Cell Protease 7 Gene. Blood 2001;97:645–651.PubMedCrossRefGoogle Scholar
  16. 16.
    Silvers W. The Coat Colors of Mice: A Model for Mammalian Gene Action and Interaction. New York: Springer-Verlag. 1979.Google Scholar
  17. 17.
    Stechschulte DJ, Sharma R, Dileepan KN, et al. Effect of the mi Allele on Mast Cells, Basophils, Natural Killer Cells, and Osteoclasts in C57B1/6J Mice. J Cell Physiol 1987;132:565–570.PubMedCrossRefGoogle Scholar
  18. 18.
    Steingrimsson E, Moore KJ, Lamoreux ML, et al. Molecular Basis of Mouse Microphthalmia (mi) Mutations Helps Explain Their Developmental and Phenotypic Consequences. Nat. Genet. 1994;8,256–263.PubMedCrossRefGoogle Scholar
  19. 19.
    Stevens J, Loutit JF. Mast Cells in Spotted Mutant Mice (W Ph mi). Proc R Soc Lond B Biol Sci 1982;215:405–409.PubMedCrossRefGoogle Scholar
  20. 20.
    20. Tsujimura T, Morii E, Nozaki M, et al. Involvement of Transcription Factor Encoded by the mi Locus in the Expression of c-kit Receptor Tyrosine Kinase in Cultured Mast Cell of Mice. Blood 1996;88:1225–1233.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Yukihiko Kitamura
    • 1
  • Eiichi Morii
    • 1
  • Tomoko Jippo
    • 1
  • Akihiko Ito
    • 1
  1. 1.Department of PathologyOsaka University Medical Schoo/Graduate School of Frontier BioscienceOsakaJapan

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