Sheep Models of Postinfarction Left Ventricular Remodeling

  • L. Henry EdmundsJr
  • Joseph H. GormanIII
  • Robert C. Gorman
Part of the Progress in Experimental Cardiology book series (PREC, volume 5)


This chapter describes various sheep models that faithfully and consistendy reproduce major manifestations of adverse postinfarction left ventricular remodeling following acute myocardial infarctions in patients. The models are produced by simply occluding coronary arteries that supply 21 to 24 percent of the left ventricular mass in different, specific locations. The advantages of these large animal models are illustrated by studies of early and late reperfusion of ischemic myocardium and studies restraining infarct or mitral annular expansion on the remodeling process.

Key words

Acute myocardial infarction ventricular remodeling sheep reperfusion infarct restraint collagen apoptosis 


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • L. Henry EdmundsJr
    • 1
  • Joseph H. GormanIII
    • 1
  • Robert C. Gorman
    • 1
  1. 1.From the Harrison Department of Surgery School of MedicineUniversity of PennsylvaniaPhiladelphia

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