Sheep Models of Postinfarction Left Ventricular Remodeling

  • L. Henry EdmundsJr
  • Joseph H. GormanIII
  • Robert C. Gorman
Part of the Progress in Experimental Cardiology book series (PREC, volume 5)

Abstract

This chapter describes various sheep models that faithfully and consistendy reproduce major manifestations of adverse postinfarction left ventricular remodeling following acute myocardial infarctions in patients. The models are produced by simply occluding coronary arteries that supply 21 to 24 percent of the left ventricular mass in different, specific locations. The advantages of these large animal models are illustrated by studies of early and late reperfusion of ischemic myocardium and studies restraining infarct or mitral annular expansion on the remodeling process.

Key words

Acute myocardial infarction ventricular remodeling sheep reperfusion infarct restraint collagen apoptosis 

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References

  1. 1.
    http://www.americanheart.org/2000/heart and stroke statistical update.Google Scholar
  2. 2.
    Gheorghiade M, Bonow RO. 1998. Chronic heart failure in the United States. A manifestation of coronary artery disease. Circulation 97:282–289.PubMedCrossRefGoogle Scholar
  3. 3.
    Braunwald E. 1997. Heart Disease: A Textbook of Cardiovascular Medicine (5th Edition). Philadelphia, W.B. Saunders.Google Scholar
  4. 4.
    Hickey MS, Smith LR, Muhlbaier LH, et al. 1988. Current prognosis of ischemic mitral regurgitation. Circulation 78:1–51.CrossRefGoogle Scholar
  5. 5.
    Frantz E, Weininger F, Oswald H, Fleck E. 1991. Predictors for mitral regurgitation in coronary artery disease. In Ischemic Mitral Incompetence, ed. by H.O. Vetter, R. Hetzer, H. Schmutzler. N.Y., Springer-Verlag, p. 57.Google Scholar
  6. 6.
    Edmunds LH Jr. 1997. Ischemic Mitral Regurgitation in Cardiac Surgery in the Adult, Edmunds LH Jr (Ed), McGraw-Hill Publishing Co., New York, NY, pp. 657–676.Google Scholar
  7. 7.
    Vastesaeger MM, Van Der Straeten PP, Friart J, et al. 1957. Les anastomoses intercoronariennes telles qu’elles appraissent a la coronarographie post mortem. Acta Cardiologica 12:365–401.PubMedGoogle Scholar
  8. 8.
    Ratcliffe MB, Gupta KB, Streicher JT, Savage EB, Bogen DK, Edmunds LH Jr. 1995. Use of sonomicrometry and multidimensional scaling to determine the three-dimensional coordinates of multiple cardiac locations: Feasibility and initial implementation. IEEE Trans Biomed Eng 42: 587–598.PubMedCrossRefGoogle Scholar
  9. 9.
    Gorman JH, Gupta KB, Streicher JT, Gorman RC, Jackson BM, Ratcliffe MB, Bogen DK, Edmunds LH Jr. 1996. Dynamic three-dimensional imaging of the mitral valve and left ventricle using rapid sonomicrometry array localization. J Thorac Cardiovasc Surg 112:712–725.PubMedCrossRefGoogle Scholar
  10. 10.
    Daughters GT, Sanders WJ, Miller DC, Schwartzkopf A, Mead CW, Ingels NB. 1988. A comparison of two analytical systems for 3-D reconstruction from biplane videoradiograms. Proc Comp Cardiol (ICCC) 15:79–82.Google Scholar
  11. 11.
    Maxwell MP, Hearse DJ, Yellon DM. 1987. Species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction. Cardiovasc Res 21:737–746.PubMedCrossRefGoogle Scholar
  12. 12.
    Markovitz LJ, Savage EB, Ratcliffe MB, Bavaria JE, Kreiner G, Iozzo RV, Hargrove WC, Bogen DK, Edmunds LH Jr. 1989. A large animal model of left ventricular aneurysm. Ann Thor Surg 48:838–845.CrossRefGoogle Scholar
  13. 13.
    Kelley ST, Malekan R, Gorman JH III, Jackson BM, Gorman RC, Suzuki Y, Plappert T, Bogen DK, St. John-Sutton MG, Edmunds LH Jr. 1999. Restraining infarct expansion preserves left ventricular geometry and function after acute myocardial infarction. Circulation 99:135–142.PubMedCrossRefGoogle Scholar
  14. 14.
    Jackson BM, Gorman JH III, St. John-Sutton MG, Edmunds LH Jr, Gorman RC. Post-infarction ventricular remodeling: progressive borderzone expansion leads to heart failure. In press. JACC.Google Scholar
  15. 15.
    Llaneris M, Nance ML, Streicher JT, Linden PL, Downing SW, Lima JAC, Deac R, Edmunds LH Jr. 1993. Pathogenesis of ischemic mitral insufficiency. J Thorac Cardiovasc Surg 105:439–443.Google Scholar
  16. 16.
    Llaneris M, Nance ML, Streicher JT, Lima JAC, Savino JS, Bogen DK, Deac RFP, Ratcliffe MB, Edmunds LH Jr. 1994. A large animal model of ischemic mitral regurgitation. Ann Thor Surg 57:432–439.CrossRefGoogle Scholar
  17. 17.
    Gorman RC, McCaughan JS, Ratcliffe MB, Gupta KB, Streicher JT, Ferrari VA, St. John-Sutton MG, Bogen DK, Edmunds LH Jr. 1995. Pathogenesis of acute ischemic mitral regurgitation in three dimensions. J Thorac Cardiovasc Surg 109:684–693.PubMedCrossRefGoogle Scholar
  18. 18.
    Gorman JH III, Gorman RC, Jackson BM, Hiramatsu Y, Gikakis N, Kelley ST, Sutton MSJ, Plappert T, Edmunds LH Jr. 1997. Distortions of the mitral valve in acute ischemic mitral regurgitation. Ann Thor Surg 64:1026–1031.CrossRefGoogle Scholar
  19. 19.
    Gorman JH III, Gorman RC, Jackson BM, Moainie SA, St. John-Sutton MG, Edmunds LH Jr. Dynamic changes in the annular-papillary muscle relationship during chronic mitral regurgitation. In press Ann Thoracic Surg.Google Scholar
  20. 20.
    Gorman JH III, Gorman RC, Plappert T, Jackson BM, Hiramatsu Y, St. John-Sutton MG, Edmunds LH Jr. 1998. Infarct size and location determine development of mitral regurgitation in the sheep model. J Thorac Cardiovasc Surg 115:615–622.PubMedCrossRefGoogle Scholar
  21. 21.
    Moainie SL, Gorman JH III, Guy TS, Bowen FW, Jackson BM, Plappert T, Narula N, St. John Sutton MG, Narula J, Edmunds LH Jr, Gorman RC. An ovine model of postinfarction, dilated cardiomyopathy. Submitted Ann Thor Surg.Google Scholar
  22. 22.
    Kreiner G, Gottleib CD, Yeh I-T, Furukawa S, Miller JM, Edmunds LH Jr, Bavaria JE, Bernstein RC, Hargrove WC III, Tyson GS. 1989. Ventricular tachycardia in an ovine model of left ventricular aneurysm. Surg Forum 40:219–221.Google Scholar
  23. 23.
    Kreiner G, Gottlieb CD, Furukawa S, Simson MB, Tyson GS, Edmunds LH Jr. 1992. Late potentials in an ovine model of acute transmural myocardial infarction. J Appl Physiol 73:841–846.PubMedGoogle Scholar
  24. 24.
    Bowen FW, Hattori T, Narula N, Salgo IG, Plappert T, St. John Sutton MG, Edmunds LH Jr. 2001. Reappearance of myocytes in ovine infarcts produced by six hours of complete ischemia followed by reperfusion. Ann Thor Surg 71:1845–1855.CrossRefGoogle Scholar
  25. 25.
    Bowen FW, Jones S, Narula N, St. John Sutton MG, Plappert T, Edmunds LH Jr, Dixon IMC. 2001. Restraining acute infarct expansion decreases collagenase activity in borderzone myocardium. Ann Thorac Surg 72:1950–1956.PubMedCrossRefGoogle Scholar
  26. 26.
    Moainie SL, Guy TS, Gorman JH III, Plappert T, Jackson BM, St. John-Sutton MG, Edmunds LH Jr, Gorman RC. Infarct restraint attenuates remodeling and reduces chronic ischemic mitral regur-gitation following posterolateral Infarction. In press Ann Thorac Surg.Google Scholar
  27. 27.
    Guy S, Moainie SL, Jackson BM, Bowen F, Plappert T, St. John-Sutton M, Edmunds LH Jr, Gorman JH III, Gorman RC. 2001. Prophylactic mitral annuloplasty prevents mitral regurgitation but not heart failure after posterolateral myocardial infarction. Surgical Forum 52:102–103.Google Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • L. Henry EdmundsJr
    • 1
  • Joseph H. GormanIII
    • 1
  • Robert C. Gorman
    • 1
  1. 1.From the Harrison Department of Surgery School of MedicineUniversity of PennsylvaniaPhiladelphia

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