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Calcium-Sensing Receptor pp 149–172Cite as

The Calcium-Sensing Receptor (CaR) and Human Disease

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Part of the book series: Endocrine updates ((ENDO,volume 19))

Abstract

Shortly after the initial identification of the bovine sequence encoding the extracellular calcium-sensing receptor (CaR) (1), human genetic studies helped clarify the central and non-redundant role of the CaR in normal calcium homeostasis. Through its effects on kidney, bone, and intestine, regulated PTH secretion maintains the concentration of serum Ca2+in humans within a narrow range (between 9.0 and 10.4 mg/dl). In several now well-described disorders resulting from alterations in the gene encoding the CaR (gene name CASR), this precise regulation of serum calcium concentration is disturbed.

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  1. Endocrine-Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA

    Claudine H. Kos Ph.D. & Martin R. Pollak M.D.

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  1. Endocrine-Hypertension Division Department of Medicine, Brigham and Women’s Hospital Harvard Medical School, Boston, Massachusetts, USA

    Naibedya Chattopadhyay  & Edward M. Brown  & 

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Kos, C.H., Pollak, M.R. (2003). The Calcium-Sensing Receptor (CaR) and Human Disease. In: Chattopadhyay, N., Brown, E.M. (eds) Calcium-Sensing Receptor. Endocrine updates, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9256-7_7

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