Advertisement

Calcium-sensing Receptor and Neoplastic Transformation

  • Enikö Kállay
  • Heide S. Cross
  • Meinrad Peterlik
Part of the Endocrine updates book series (ENDO, volume 19)

Abstract

There is increasing evidence from epidemiological studies that some of the most frequent human cancers are associated with a specific nutritional pattern: For example, an increased risk of breast cancer is believed to result from high dietary fat and/or low intake of vitamin D and calcium (1,2,3). Similarly, it has been known for a long time that colorectal cancer shows a strong positive correlation with dietary fat, while low vitamin D and dietary calcium are additional independent risk factors for the disease (4,5,6). From the study of Garland et al. (5) it can be implied that the incidence of colorectal cancer may be reduced by approximately 70% if daily calcium intake is raised from 800 to 1400 mg. The incidence of prostate cancer is also clearly linked to high fat consumption, whereas studies on a possible association with dietary calcium levels did not yield conclusive results (7,8).

Keywords

Parathyroid Adenoma Leydig Tumor Cell Bovine Parathyroid Cell Receptor Messenger Ribonucleic Acid Colonic Epithelial Cell Proliferation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lipkin M, Newmark HL 1999 Vitamin D, calcium and prevention of breast cancer: a review. J Am Coll Nutr 18(Suppl 5) 392S–397SPubMedGoogle Scholar
  2. 2.
    Yang CY, Chiu HF, Cheng MF, Hsu TY, Cheng MF, Wu TN 2000 Calcium and magnesium in drinking water and the risk of death from breast cancer. J Toxicol Environ Health A 60:231–241PubMedCrossRefGoogle Scholar
  3. 3.
    Favero A, Parpinel M, Franceschi S 1998 Diet and risk of breast cancer: major findings from an Italian case-control study. Biomed Pharmacother 52:109–115PubMedCrossRefGoogle Scholar
  4. 4.
    Garland C, Barrett-Connor E, Rossof AH, Shekelle RB, Criqui MH, Oglesby P 1985 Dietary vitamin D and calcium and risk of colrectal cancer: a 19 year prospective study in men. Lancet 1:307–309PubMedCrossRefGoogle Scholar
  5. 5.
    Garland CF, Garland FC, Gorham ED 1991 Can colon cancer incidence and death rates be reduced with calcium and vitamin D? Am J Clin Nutr 54:193S–201SPubMedGoogle Scholar
  6. 6.
    Lipkin M, Newmark HL, Kelloff G eds. 1991 Calcium, vitamin D and prevention of colon cancer. Boston: CRC PressGoogle Scholar
  7. 7.
    Hayes RB, Ziegler RG, Gridley G, Swanson C, Greenberg RS, Swanson GM, Schoenberg JB, Silverman DT, Brown LM, Pottern LM, Liff J. Schwartz AG, Fraumeni JF, Hoover RN 1999 Dietary factors and risks for prostate cancer among blacks and whites in the United States. Cancer Epidemiol Biomarkers Prev 8:25–34PubMedGoogle Scholar
  8. 8.
    Giovannucci E, Rimm EB, Wölk A, Ascherio A, Stampfer MJ, Colditz GA, Willett WC 1998 Calcium and fructose intake in relation to risk of prostate cancer. Cancer Res 58:442–447PubMedGoogle Scholar
  9. 9.
    Carroll KK, Jacobson EA, Eckel LA, Newmark HL 1991 Calcium and carcinogenesis of the mammary gland. Am J Clin Nutr 54:206S–208SPubMedGoogle Scholar
  10. 10.
    Lipkin M, Newmark H 1985 Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at high risk for familial colonic cancer. N Engl J Med 313:1381–1384PubMedCrossRefGoogle Scholar
  11. 11.
    Nobre-Leitao C, Chaves P, Fidalgo P Cravo M, Gouveia-Oliveira A, Ferra MA, Mira FC 1995 Calcium regulation of colonic crypt cell kinetics: evidence for a direct effect in mice. Gastroenterology 109:498–504PubMedCrossRefGoogle Scholar
  12. 12.
    Holt PR, Attilasoy EO, Gilman J, Guss J, Moss SF, Newmark H, Fan K, Yang K, Lipkin M 1998 Modulation of abnormal colonic epithelial cell proliferation and differentiation by low-fat dairy foods: a randomized control trial. J Am Med Assoc 280:1074–1079CrossRefGoogle Scholar
  13. 13.
    Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, Yuspa SH 1980 Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19: 245–254PubMedCrossRefGoogle Scholar
  14. 14.
    Babcock MS, Marino MR, Gunning WT, Stoner GD 1983 Clonal growth and serial propagation of rat oesophageal epithelila cells. In Vitro (Rockville) 19:403–415Google Scholar
  15. 15.
    McGrath CM, Soule HD 1986 Calcium regulation of normal mammary epithelial cell growth in culture. In Vitro (Rockville) 22:6–12Google Scholar
  16. 16.
    Hennings H, Kruszewski FH, Yuspa SH, Tucker RW 1989 Intracellular calcium alteration in normal and neoplastic keratinocytes. Carcinogenesis 10:777–780PubMedCrossRefGoogle Scholar
  17. 17.
    Buset M, Lipkin M, Winawer S, Swaroop S, Friedman E 1986 Inhibition of human colonic epithelial cell proliferation in vivo and in vitro. Cancer Res 46: 5426–5430PubMedGoogle Scholar
  18. 18.
    Lipkin M, Friedman E, Winawer SJ, Newmark H 1989 Colonic epithelial cell proliferation in responders and nonresponders to supplemental dietary calcium. Cancer Res 49:248–254PubMedGoogle Scholar
  19. 19.
    Whitfield JF 1991 Calcium, switches, cell cycles, differentiation and death. In: Lipkin M, Newmark HL, Kelloff G. eds. Calcium, vitamin D and prevention of colon cancer. Boston: CRC PressGoogle Scholar
  20. 20.
    Cross HS, Huber C, Peterlik M 1991 Antiproliferative effect of 1,25-dihydroxyvitamin D3 and its analogs on human colon adenocarcinoma cells (Caco-2): influence of extracellular calcium. Biochem Biophys Res Commun 179:57–62PubMedCrossRefGoogle Scholar
  21. 21.
    Cross HS, Pavelka M, Slavik J, Peterlik M 1992 Growth control of human colon cancer cells by vitamin D and calcium in vitro. J Natl Cancer Inst. 84: 1355–1357PubMedCrossRefGoogle Scholar
  22. 22.
    Kállay E, Bajna E, Wrba F, Kriwanek S, Peterlik M, Cross HS 2000 Dietary calcium and growth modulation of human colon cancer cells: role of the extracellular calcium-sensing receptor. Cancer Detect Prev 24:127–136PubMedGoogle Scholar
  23. 23.
    Hulla W, Kallay E, Krugluger W, Peterlik M, Cross HS 1995 Growth control of human colon-adenocarcinoma-derived Caco-2 cells by vitamin-D compounds and extracellular calcium in vitro: relation to c-myc oncogene and vitamin-D-receptor expression. Int J Cancer 62:711–716PubMedCrossRefGoogle Scholar
  24. 24.
    Kállay E, Kifor O, Chattopadhyay N, Brown EM, Bischof MG, Peterlik M, Cross HS 1997 Calcium-dependent c-myc proto-oncogene expression and proliferation of Caco-2 cells: a role for a luminal extracellular calcium-sensing receptor. Biochem Biophys Res Comm. 232: 80–83PubMedCrossRefGoogle Scholar
  25. 25.
    Brown EM, Gamba G, Riccardi D, Lombardi M, Butters RB, Kifor O, Sun A, Hediger MA, Lytton J, Hebert SC 1993 Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature 636:575–580CrossRefGoogle Scholar
  26. 26.
    Brown EM, Pöllak M, Chou YH, Seidman CE, Seidman JG, Hebert SC 1995 The cloning of extracellular Ca2+-sensing receptors from parathyroid and kidney: molecular mechanisms of extracellular Ca2+-sensing. J Nutr 125:1965S–1970SPubMedGoogle Scholar
  27. 27.
    Garrett JE, Tamir H, Kifor O, Simin RT, Rogers, KV, Mithal A, Gagel RF, Brown EM 1995 Calcitonin secreting cells of the thyroid express an extracellular calcium receptor gene. Endocrinology 136:5202–5211PubMedCrossRefGoogle Scholar
  28. 28.
    House MG, Kohlmeier L, Chattopadhyay N, Kifor O, Yamaguchi T, Leboff MS, Glowacki J, Brown EM 1997 Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells. J Bone Miner Res 12:1959–1970PubMedCrossRefGoogle Scholar
  29. 29.
    Gama L, Baxendale-Cox LM, Breitwieser GE 1997 Ca2+ sensing receptors in intestinal epithelium. Am J Physiol 42:C1168–C1175Google Scholar
  30. 30.
    Brown EM, Katz C, Butters R, Kifor O 1991 Polyarginine, polylysine, and protamine mimic the effects of high extracellular calcium concentrations on dispersed bovine parathyroid cells. J Bone Miner Res 6: 1217–1225PubMedCrossRefGoogle Scholar
  31. 31.
    Kállay E, Thakker R, Peterlik M, Cross HS 2000 Expression of a functional calcium-sensing receptor in colorectal cancer cells. Bone 27(5): 733CrossRefGoogle Scholar
  32. 32.
    Corbetta S, Mantovani G, Lania A, Borgato S, Vicentini L, Beretta E, Faglia G, Di-Blasio AM, Spada A 2000 Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia. Clin Endocrinol (Oxf). 52:339–348CrossRefGoogle Scholar
  33. 33.
    Romoli R, Lania A, Mantovani G, Corbetta S, Persani L, Spada A 1999 Expression of calcium-sensing receptor and characterization of intracellular signaling in human pituitary adenomas. J Clin Endocrinol Metab 84:2848–2853PubMedCrossRefGoogle Scholar
  34. 34.
    Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Brown EM 2000 Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Ley dig cell model of humoral hypercalcemia of malignancy. Biochem Biophys Res Commun 269:427–432PubMedCrossRefGoogle Scholar
  35. 35.
    Buchs N, Manen D, Bonjour JP, Rizzoli R 2000 Calcium stimulates parathyroid hormone-related protein production in Ley dig tumor cells through a putative cation-sensing mechanism. Eur J Endocrinol 142:500–505PubMedCrossRefGoogle Scholar
  36. 36.
    Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Butters RR, Brown EM 2000 Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. Endocrinology 131:4357–4364CrossRefGoogle Scholar
  37. 37.
    Lin KI, Chattopadhyay N, Bai M, Alvarez R, Dang CV, Baraban JM, Brown EM, Ratan RR 1998 Elevated extracellular calcium can prevent apoptosis via the calcium-sensing receptor. Biochem Biophys Res Commun 249:325–331PubMedCrossRefGoogle Scholar
  38. 38.
    Chattopadhyay N, Mithal A, Brown EM 1996 The calcium-sensing receptor: A window into the physiology and pathophysiology of mineral ion metabolism. Endocr Rev 17:289–307PubMedGoogle Scholar
  39. 39.
    Brown EM, MacLeod RJ 2001 Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81:239–297PubMedGoogle Scholar
  40. 40.
    Firsov D, Aarab L, Mandon B, Siaume-Perez S, Rouffignac SD, Chabardes D 1995 Arachidonic acid inhibits hormone-stimulated cAMP accumulation in the medullary thick ascending limb of the rat kidney by a mechanism sensitive to pertussis toxin. Pfluegers Arch 429:636–646CrossRefGoogle Scholar
  41. 41.
    Emanuel RL, Adler GK, Kifor O, Quinn SJ, Fuller F, Krapcho K, Brown EM 1996 Calcium-sensing receptor expression and regulation by extracellular calcium in the AtT-20 pituitary cell line. Mol Endocrinol 10: 555–565PubMedCrossRefGoogle Scholar
  42. 42.
    Kifor O, Diaz R, Butters R, Brown EM 1997 The Ca2+-sensing receptor (CaR) activates phospholipases C, A2, and D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells. J Bone Miner Res 12:715–725PubMedCrossRefGoogle Scholar
  43. 43.
    Yamaguchi T, Chattopadhyay N, Brown EM 2000 G Protein-coupled extracellular Ca2+-sensing receptor (CaR): roles in cell signaling and control of diverse cellular functions. Adv Pharmacol 47:209–253PubMedCrossRefGoogle Scholar
  44. 44.
    Kifor O, Congo D, Brown EM 1990 Phorbol esters modulate the high Ca2+ stimulated accumulation of inositol phosphates in bovine parathyroid cells. J Bone Miner Res 5:1003–1011PubMedCrossRefGoogle Scholar
  45. 45.
    Farnebo F, Enberg U, Grimelius L, Backdahl M, Schalling M, Larsson C, Farnebo LO 1997 Tumor-specific decreased expression of calcium sensing receptor messenger ribonucleic acid in sporadic primary hyperparathyroidism. J Clin Endocrinol Metab 82:3481–3486PubMedCrossRefGoogle Scholar
  46. 46.
    Farnebo F, Hoog A, Sandelin K, Larsson C, Farnebo LO 1998 Decreased expression of calcium-sensing receptor messenger ribonucleic acids in parathyroid adenomas. Surgery 124:1094–1098PubMedCrossRefGoogle Scholar
  47. 47.
    Kifor O, Moore FJ, Wang P, Goldstein M, Vassilev P, Kifor I, Hebert SC, Brown EM 1996 Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 81:1598–1606PubMedCrossRefGoogle Scholar
  48. 48.
    Gogusev J, Duchambon P, Hory B, Giovannini M, Goureau Y, Sarfati E, Drueke TB 1997 Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int 51:328–336PubMedCrossRefGoogle Scholar
  49. 49.
    Roussanne MC, Lieberherr M, Sourbielle JC, Sarfati E, Drueke T, Bourdeau A 2001 Human parathyroid cell proliferation in response to calcium, NPS R-467, calcitriol and phosphate. Eur J Clin Invest 31:610–616PubMedCrossRefGoogle Scholar
  50. 50.
    Yano S, Sugimoto T, Tsukamoto T, Chihara K, Kobayashi A, Kitazawa S, Maeda S, and Kitazawa R 2000 Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism. Kidney Int 58:1980–1986PubMedCrossRefGoogle Scholar
  51. 51.
    Chikatsu N, Fukumoto S, Takeuchi Y, Suzawa M, Obara T, Matsumoto T, Fujita T 2000 Cloning and Characterization of Two Promoters for the Human Calcium-sensing Receptor (CaSR) and Changes of CaSR Expression in Parathyroid Adenomas J Biol Chem 275:7553–7557PubMedCrossRefGoogle Scholar
  52. 52.
    Sheinin Y, Kallay E, Wrba F, Kriwanek S, Peterlik M, Cross HS 2000 Immunocytochemical Localization of the Extracellular Calcium-Sensing Receptor in Normal and Malignant Human Large Intestinal Mucosa. J Histochem Cytochem 48:595–601PubMedCrossRefGoogle Scholar
  53. 53.
    Goebel SU, Peghini PL, Goldsmith PK, Spiegel AM, Gibril F, Raffeld M, Jensen RT, Serrano J 2000 Expression of the calcium-sensing receptor in gastrinomas. J Clin Endocrinol Metab 85:4131–4137PubMedCrossRefGoogle Scholar
  54. 54.
    Hosokawa Y, Pollak MR, Brown EM, Arnold A 1995 Mutational analysis of the extracellular Ca2+-sensing receptor gene in human parathyroid tumors. J Clin Endocrinol Metab 80:3107–3110PubMedCrossRefGoogle Scholar
  55. 55.
    Cetani F, Pinchera A, Pardi E, Cianferotti L, Vignali E, Picone A, Miccoli P, Viacava P, Marcocci C 1999 No Evidence for Mutations in the Calcium-Sensing Receptor Gene in Sporadic Parathyroid Adenomas. J Bone Mineral Res 14:878–882CrossRefGoogle Scholar
  56. 56.
    Speer G, Cseh K, Fuszek P, Dworak O, Vargha P, Takacs I, Nagy Z, Lakatos P 2001 The role of estrogen receptor, vitamin D receptor and calcium receptor genotypes in the pathogenesis of colorectal cancer. Orv Hetil 142:947–951PubMedGoogle Scholar
  57. 57.
    Whitfield JF 1997 Calcium: cell cycle driver, differentiator and killer. Chapman-Hall, New YorkGoogle Scholar
  58. 58.
    Chattopadhyay N, Cheng I, Rogers K, Riccardi D, Hall A, Diaz R, Hebert SC, Soybel DI, Brown EM 1998 Identification and localization of extracellular Ca2+-sensing receptor in rat intestine. Am J Physiol 274: G122–G130PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Enikö Kállay
    • 1
  • Heide S. Cross
    • 1
  • Meinrad Peterlik
    • 1
  1. 1.Department of PathophysiologyUniversity of Vienna Medical SchoolViennaAustria

Personalised recommendations