Skip to main content

Segmented Polyetheresters Containing Hydrogen Bonding Units

  • Conference paper
  • 1007 Accesses

Abstract

In recent years, the growing interest in the delivery of protein and peptide drugs stimulated the development of new materials with tailored properties. Requisites to be fulfilled are the non-denaturation of the incorporated protein as well as the loaded drug and the possibility of controlling both the mechanism and kinetics of polymer degradation and drug release1.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ulrich, K. E., Cannizzaro, S. M., Langer, R., and Shakesheff, K. M., 1999, Polymeric Systems for Controlled Drug Release. Chem. Rev. 99: 3181–3198.

    Article  Google Scholar 

  2. Jeong, B., Bae, Y. H., and Kim, S. W., 2000, Drug Release from Biodegradable Injectable Thermosensitive Hydrogel of PEG-PLGA-PEG Triblock Copolymers. J. Control Rel. 63: 155–163.

    Article  CAS  Google Scholar 

  3. Peracchia, M. T., Gref, R., Minamitake, Y., Domb, A., Lotan, N., and Langer, R., 1997, PEG-Coated Nanospheres from Amphiphilic Diblock and Multiblock Copolymers: Investigation of their Drug Encapsulation and Release Characteristics. J. Control Rel 46: 223–231.

    Article  CAS  Google Scholar 

  4. Saltzman, W. M., and Olbricht, W. L., 2002, Building Drug Delivery into Tissue Engineering. Nature Rev. 1: 177–186.

    Article  CAS  Google Scholar 

  5. Conn, D., and Younes, H., 1988, Biodegradable PEO/PLA Block Copolymers. J. Biomed. Mater. Res. 22: 993–1009.

    Article  Google Scholar 

  6. Casey, D. J., Jarret, P. K., and Rosati, I., 1987, Diblock and Triblock Copolymers. U. S. Pat. 4,716,203; Chem. Abstr. 108: 132531.

    Google Scholar 

  7. Cerrai, P., Tricoli, M., Andruzzi, F., and Paci, M., 2000, Polyether Ester Block Copolymers by non-Catalysed Polymerization of ε-Caprolactone with Poly(ethylene glycol). Polymer 30: 338–343.

    Article  Google Scholar 

  8. Bakker, D., van Blitterswijk, C. A., Hesseling, S. C., Koerten, H. K., Kuijpers, W., and Grote, J. J., 1990, Biocompatibility of a Polyether Urethane, Polypropilene Oxide, and a Polyether Polyester Copolymer. A Qualitative and Quantitative Study of three Alloplastic Tympanic Membrane Materials in the Rat Middle Ear. J. Biomed. Mater. Res. 24: 489–515.

    Article  CAS  Google Scholar 

  9. Bezemer, J. M., Oude Werne P., Grijpma, D. W., Dijkstra, P. J., van Blitterswijk, C. A., and Feijen, J., 2000, Amphiphilic Poly(ether ester amide) Multiblock Copolymers as Biodegradable Matrices for the Controlled Release of Proteins. J. Biomed. Mater. Res. 52: 8–17.

    Article  CAS  Google Scholar 

  10. Stapert, H R., Bouwens, A. M., Dijkstra, P. J., and Feijen, J., 1999, Enviromentally Degradable Aliphatic Poly(ester amide)s based on Short, Symmetrical and Uniform Bisamide-Diol Bloks 1. Synthesis and Interchange Reactions, Macromol Chem. Phys. 200: 1921–1929.

    Article  CAS  Google Scholar 

  11. Alia, L., Rodriguez-Galan, A., and Munoz-Guerra, S., 2000, Hydrolytic and Enzymatic Degradation of Copoly(ester amide)s based on L-Tartaric and Succinic acids. Polymer 41: 6995–7002.

    Article  Google Scholar 

  12. Paredes, N., Rodriguez-Galan, A., Puiggali, J., and Peraire, C., 1998, Studies on the Biodegradation and Biocompatibility of a New Poly(ester amide) Derived from L-Alanine. J. Appl. Polym. Sci. 69: 1537–1549.

    Article  CAS  Google Scholar 

  13. Paredes, N., Rodriguez-Galan, A., and Puiggali, J., 1998, Synthesis and Characterization of a Family of Biodegradable Poly(ester amide)s Derived from Glycine. J. Polym. Sci. Part A: Polym. Chem. 36: 1271–1282.

    Article  CAS  Google Scholar 

  14. Tuominen, J., and Seppala, J. V., 2000, Synthesis and Characterization of Lactic Acid Based Poly(ester amide). Macromolecules 33: 3530–3535.

    Article  CAS  Google Scholar 

  15. Villuendas, I., Bou, J. J., Rodriguez-Galan, A., and Munoz-Guerra, S., 2001, Alternanting Copoly(ester amide)s Derived from Amino Alcohols and L-tartaric and Succinic Acids. Macromol. Chem. Phys. 202: 236–244.

    Article  CAS  Google Scholar 

  16. Signori, F., Solaro, R., Chiellini, E., Lips, P.A.M., Dijkstra, P. J., and Feijen, J., 2003, Synthesis and Characterization of Segmented Poly(ether ester)s Containing H-bonding Units, Macromol. Chem. Phys. submitted.

    Google Scholar 

  17. Deschamps, A. A, Grijpma, D W, Feijen, J., 2002, Phase Separation and Physical Properties of PEO-Containing Poly(ether ester amide)s, J. Biomat. Sci. 13:1337–1352.

    Google Scholar 

  18. Signori, F., Solaro, R., Chiellini, E., Lips, P.A.M., Dijkstra, P. J., and Feijen, J., 2003, Synthesis and Characterization of Segmented Poly(ether ester)s Containing H-bonding Units and PEG segments, Macromol. Chem. Phys. submitted.

    Google Scholar 

  19. Owens, D. K., and Wendt, R. C., 1969, Estimation of the Surface Free Energy of Polymers. J. Appl. Polym. Sci. 13: 1741–1747.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this paper

Cite this paper

Signori, F., Solaro, R., Chiellini, E., Lips, P.A.M., Dijkstra, P.J., Feijen, J. (2003). Segmented Polyetheresters Containing Hydrogen Bonding Units. In: Chiellini, E., Solaro, R. (eds) Biodegradable Polymers and Plastics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9240-6_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-9240-6_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4854-2

  • Online ISBN: 978-1-4419-9240-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics