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Augmented Energy Transfer in Rat Heart Mitochondria: Compensatory Response to Abnormal Household of Energy in Acute Diabetes

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Atherosclerosis, Hypertension and Diabetes

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 8))

Abstract

Hearts of rats with diabetes mellitus are generally characterized by energy demands exceeding their energy production. Nevertheless, although working permanently in energy deficiency, the diabetic hearts may also exhibit decreased vulnerabil-ity to ischemia and calcium overload. This points to presence of adaptation changes in cardiac energetics, in which at least that limited amount of energy which the diabetic heart mitochondria can produce, may be transported through the mitochondrial membrane to sites of its utilization at a non-limiting rate.

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Author information

Authors and Affiliations

  1. Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic

    Attila Ziegelhöffer, Tanya Ravingerová & Ján Styk

  2. Department of Biophysics and Chemical Physics, Faculty of Mathematics, Physics and Informatics, Comenius University, Bratislava, Slovak Republic

    Iveta Waczulíková

  3. Carl-Ludwig-Institute of Physiology, University of Leipzig, Leipzig, Germany

    Barbara Ziegelhöffer-Mihalovičová

  4. Institute of Physiology, Academy of Sciences of the Czech Republic and Centre of Cardiovascular Research, Prague, Czech Republic

    Jan Neckář

Authors
  1. Attila Ziegelhöffer
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  2. Iveta Waczulíková
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  3. Tanya Ravingerová
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Editor information

Editors and Affiliations

  1. Division of Stroke & Vascular Disease, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Grant N. Pierce PhD, FACC (Professor & Director) (Professor & Director)

  2. Department of Medicine, Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano MD, PhD (Professor Emeritus) (Professor Emeritus)

  3. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Peter Zahradka PhD (Associate Professor) & Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) (Associate Professor) &  (Distinguished Professor and Director)

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Ziegelhöffer, A., Waczulíková, I., Ravingerová, T., Ziegelhöffer-Mihalovičová, B., Neckář, J., Styk, J. (2003). Augmented Energy Transfer in Rat Heart Mitochondria: Compensatory Response to Abnormal Household of Energy in Acute Diabetes. In: Pierce, G.N., Nagano, M., Zahradka, P., Dhalla, N.S. (eds) Atherosclerosis, Hypertension and Diabetes. Progress in Experimental Cardiology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9232-1_33

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  • DOI: https://doi.org/10.1007/978-1-4419-9232-1_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4850-4

  • Online ISBN: 978-1-4419-9232-1

  • eBook Packages: Springer Book Archive

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