Augmented Energy Transfer in Rat Heart Mitochondria: Compensatory Response to Abnormal Household of Energy in Acute Diabetes

  • Attila Ziegelhöffer
  • Iveta Waczulíková
  • Tanya Ravingerová
  • Barbara Ziegelhöffer-Mihalovičová
  • Jan Neckář
  • Ján Styk
Part of the Progress in Experimental Cardiology book series (PREC, volume 8)


Hearts of rats with diabetes mellitus are generally characterized by energy demands exceeding their energy production. Nevertheless, although working permanently in energy deficiency, the diabetic hearts may also exhibit decreased vulnerabil-ity to ischemia and calcium overload. This points to presence of adaptation changes in cardiac energetics, in which at least that limited amount of energy which the diabetic heart mitochondria can produce, may be transported through the mitochondrial membrane to sites of its utilization at a non-limiting rate.

Key words

Adaptation of heart to diabetes Tolerance to ischemia Endogenous protective mechanisms in heart Mitochondrial contact sites Mitochondrial membrane fluidity 


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Attila Ziegelhöffer
    • 1
  • Iveta Waczulíková
    • 2
  • Tanya Ravingerová
    • 1
  • Barbara Ziegelhöffer-Mihalovičová
    • 3
  • Jan Neckář
    • 4
  • Ján Styk
    • 1
  1. 1.Institute for Heart ResearchSlovak Academy of SciencesBratislavaSlovak Republic
  2. 2.Department of Biophysics and Chemical PhysicsFaculty of Mathematics, Physics and Informatics, Comenius UniversityBratislavaSlovak Republic
  3. 3.Carl-Ludwig-Institute of PhysiologyUniversity of LeipzigLeipzigGermany
  4. 4.Institute of PhysiologyAcademy of Sciences of the Czech Republic and Centre of Cardiovascular ResearchPragueCzech Republic

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