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Mechanisms Underlying Contractile Dysfunction in Streptozotocin-Induced Type 1 and Type 2 Diabetic Cardiomyopathy

  • Chapter
Atherosclerosis, Hypertension and Diabetes

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 8))

Abstract

Diabetes Mellitus is characterised by fasting hyperglycemia and glucose intolerance, due to insulin deficiency, impaired effectiveness of insulin action or both. There is clear evidence of the negative influence of both type 1 diabetes and type 2 diabetes on the prevalence, severity and prognosis of cardiovascular disease. Cardiovascular disease represents the commonest cause of morbidity and mortality within diabetic patients. Human and animal studies have shown that the excess risk of cardiovascular complications cannot be explained by conventional cardiovascular risk factors alone and therefore, the diabetic state itself is likely to account for this alteration in cardiac function. The cellular mechanisms associated with contractile dysfunction and calcium mobilisation will be reviewed with respects to the streptozotocin-induced model of type 1 and type 2 diabetes mellitus.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Central Lancashire, Preston, PR 1 2HE, Lancashire, England and Department of Physiology, Faculty of Medicine & Health Sciences, United Arab Emirates University, PO Box 1766, Al Ain, United Arab Emirates

    Frank C. Howarth

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  1. Nicolas K. Bracken
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  2. Jaipaul Singh
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  3. William Winlow
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  4. Frank C. Howarth
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Editors and Affiliations

  1. Division of Stroke & Vascular Disease, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Grant N. Pierce PhD, FACC (Professor & Director) (Professor & Director)

  2. Department of Medicine, Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano MD, PhD (Professor Emeritus) (Professor Emeritus)

  3. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Peter Zahradka PhD (Associate Professor) & Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) (Associate Professor) &  (Distinguished Professor and Director)

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Bracken, N.K., Singh, J., Winlow, W., Howarth, F.C. (2003). Mechanisms Underlying Contractile Dysfunction in Streptozotocin-Induced Type 1 and Type 2 Diabetic Cardiomyopathy. In: Pierce, G.N., Nagano, M., Zahradka, P., Dhalla, N.S. (eds) Atherosclerosis, Hypertension and Diabetes. Progress in Experimental Cardiology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9232-1_30

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  • DOI: https://doi.org/10.1007/978-1-4419-9232-1_30

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