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Brain Na,K-ATPase Enzymatic Activity and Cardiovascular Regulation

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Atherosclerosis, Hypertension and Diabetes

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 8))

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Abstract

Na,K-ATPase enzymatic activity, by maintaining intracellular cation homeostasis regulates many cellular functions. This review focuses on the role of brain Na,K-ATPase activity in cardiovascular regulation. Na,K-ATPase activity in cardiovascular/osmo-regulatory nuclei may regulate cardiovascular function by modulating neurotransmitter release and/or cell responsiveness. Inhibition of Na,K-ATPase activity in cardiovascular/osmo-regulatory nuclei increases blood pressure and causes hypertension. Inversely, an increase in Na,K-ATPase activity in nuclei involved in cardiovascular/osmo-regulation decreases blood pressure in normotensive and hypertensive rats. A decrease in brain Na, K-ATPase activity is associated with several cardiovascular diseases such as salt-sensitive hypertension, heart failure post myocardial infarction (MI) and hypertension induced by suprarenal aortic constriction (SRC). In hyper-tension induced by SRC, brain Na,K-ATPase isozyme expression and activity decrease in the early phase but increase in the established phase of the hypertension. The decrease in brain Na,K-ATPase activity in salt-sensitive hypertension appears to be mediated by a direct inhibitory action of brain ouabain-like-compounds (OLCs) and reflects mainly a decrease in OC2/GC3 isozyme activity. In rats post MI, brain OLCs decrease both (Xi and a2/OC3 Na,K-ATPase isozyme activity by direct and indirect mechanisms that may not involve a change in expres-sion. Brain OLCs may indirectly modulate Na,K-ATPase activity by increasing the release of neurotransmitters such as NE and ACh that regulate Na,K-ATPase activity. The neurotransmitters involved in mediating the changes in Na,K-ATPase activity in rats post MI or in hypertension are not yet known. However, these studies suggest that brain a2/OC3 as well as C*! Na,K-ATPase isozymes may play a role in the central control of the circulation.

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Authors and Affiliations

  1. Hypertension Unit, Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    JAMES W. VAN Huysse

  2. Hypertension Unit, Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

    Frans H. H. Leenen

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  1. Mary-Anne H. Kent
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  2. JAMES W. VAN Huysse
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  3. Frans H. H. Leenen
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Editors and Affiliations

  1. Division of Stroke & Vascular Disease, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Grant N. Pierce PhD, FACC (Professor & Director) (Professor & Director)

  2. Department of Medicine, Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano MD, PhD (Professor Emeritus) (Professor Emeritus)

  3. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Peter Zahradka PhD (Associate Professor) & Naranjan S. Dhalla PhD, MD (Hon), DSc (Hon) (Distinguished Professor and Director) (Associate Professor) &  (Distinguished Professor and Director)

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Kent, MA.H., VAN Huysse, J.W., Leenen, F.H.H. (2003). Brain Na,K-ATPase Enzymatic Activity and Cardiovascular Regulation. In: Pierce, G.N., Nagano, M., Zahradka, P., Dhalla, N.S. (eds) Atherosclerosis, Hypertension and Diabetes. Progress in Experimental Cardiology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9232-1_18

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  • DOI: https://doi.org/10.1007/978-1-4419-9232-1_18

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