Variable Influence of Statins on Isoprostanes in Hyperlipidemia
Although statin therapy under normal circumstances reduces oxidation injury, the isoprostane 8-epi-PGF2α may increase various time intervals after initiation of treatment in certain patients for unknown reason. All statins seem to be equally affected. Stopping statin therapy causes reversal within about 2 weeks. During and after exercise the 8-epi-PGF2α increase is more frequent. Isoprostanes may become relevant to discover a statin side effect. The pathophysiological and clinical consequences of this finding need to be elaborated.
KeywordsStatin Therapy Oxidation Injury Statin Treatment Familial Hypercholesterolemia Paradoxical Increase
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- 2.Sinzinger H, Lupattelli G, Chehne F. Increased isoprostane 8-epi-PGF2α in statininduced myopathy, in: Proc Advances in Prostaglandin and Leukotriene Research. B Samuelsson, R Paoletti, PC Folco, E Granström (Eds) Kluwer Academic Publ, Dordrecht, 2001, pp. 197–199.Google Scholar