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Evidence for Enhanced Oxidative Stress in Coronary Heart Disease and Chronic Heart Failure

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Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 525))

Abstract

Oxidation injury has been claimed as one of the key factors in the development of coronary heart disease and chronic heart failure [1,2]. The isoprostane 8-epi-PGF22α is gaining increasing interest as reliable marker of in-vivo oxidation injury [3]. As it causes among others coronary vasoconstriction [4] its pathophysiological role may become even more important. We therefore assessed the isoprostane 8-epi-PGF2α in arteries, veins, heart valves and myocardial tissue immunochemically as well as by immunohistochemistry. Furthermore, 8-epi-PGF2α was determined in plasma and urine of patients with CHD compared to patients with dilated and ischemic CMP.

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References

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Author information

Authors and Affiliations

  1. Department of Angiology, University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria

    Roswitha Wolfram

  2. Department of Nuclear Medicine, University of Vienna, W’dhringer Gürtel 18-20, 1090, Vienna, Austria

    Anthony Oguogho

  3. Department of Nuclear Medicine, Universitá degli Studi, Policlinio Monteluce, Via Brunamonti, 06100, Perugia, Italy

    Barbara Palumbo

  4. Wilhelm Auerswald Atherosclerosis Research Group, A-1090, Vienna, Austria

    Helmut Sinzinger

Authors
  1. Roswitha Wolfram
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  2. Anthony Oguogho
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  3. Barbara Palumbo
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  4. Helmut Sinzinger
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Editor information

Editors and Affiliations

  1. University of Istanbul, Istanbul, Turkey

    Zeliha Yazici

  2. University of Milan, Milan, Italy

    Giancarlo C. Folco

  3. Harvard Medical School, Boston, Massachusetts

    Jeffrey M. Drazen

  4. Free University of Berlin, Berlin, Germany

    Santosh Nigam

  5. University of Tokyo, Tokyo, Japan

    Takao Shimizu

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© 2003 Springer Science+Business Media New York

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Wolfram, R., Oguogho, A., Palumbo, B., Sinzinger, H. (2003). Evidence for Enhanced Oxidative Stress in Coronary Heart Disease and Chronic Heart Failure. In: Yazici, Z., Folco, G.C., Drazen, J.M., Nigam, S., Shimizu, T. (eds) Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. Advances in Experimental Medicine and Biology, vol 525. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9194-2_42

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  • DOI: https://doi.org/10.1007/978-1-4419-9194-2_42

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4831-3

  • Online ISBN: 978-1-4419-9194-2

  • eBook Packages: Springer Book Archive

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