Specific Gene Expression of Isoforms in Cyclooxygenase Pathway to Generate PGJ2 Derivatives during the Differentiation of 3T3-L1 Adipocytes

  • Shan Lu
  • Masa-atsu Ohya
  • Kohji Nishimura
  • Mitsuo Jisaka
  • Tsutomu Nagaya
  • Kazushige Yokota
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 525)

Abstract

Obesity is a risk factor to cause complicated diseases such as diabetes and others. Obesity accompanies an increase in the number or size of adipocytes, which should involve the changes in the life cycle of fat cells. During these processes, peroxisome proliferator-activated receptor (PPAR)γ, which is a member of nuclear receptors, plays an important role in the differentiation and the progression of insulin resistance in adipocytes [4]. PPARγ was originally recognized by the fact of the activation by antidiabetic drugs. Later, fatty acids and eicosanoids were found to activate PPARγ as endogenous ligands [1,3].

Keywords

Obesity Albumin Dehydration Prostaglandin Kelly 

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Shan Lu
    • 1
  • Masa-atsu Ohya
    • 1
  • Kohji Nishimura
    • 1
  • Mitsuo Jisaka
    • 1
  • Tsutomu Nagaya
    • 1
  • Kazushige Yokota
    • 1
  1. 1.Department of Life Science and BiotechnologyShimane UniversityMatsueJapan

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