Abstract
Phospholipase A2 (PLA2), which hydrolyzes the sn-2 position of glycerophospholipid to liberate free fatty acid and lysophospholipid, occurs in multiple forms in mammals. To date, four major classes of PLA2 enzymes have been identified, including secretory PLA2s (sPLA2s), cytosolic PLA2s (cPLA2s), Ca2+-independent PLA2s (iPLA2s) and platelet-activating factor acetylhydrolases (PAF-AHs). In this paper, we summarize our current understanding of the regulation of cellular arachidonate (AA) metabolism by sPLA2, cPLA2 and iPLA2 enzymes. More details are described in our recent reviews [1,2].
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References
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Murakami, M., Kudo, I. (2003). Cellular Arachidonate-Releasing Functions of Various Phospholipase A2s. In: Yazici, Z., Folco, G.C., Drazen, J.M., Nigam, S., Shimizu, T. (eds) Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research. Advances in Experimental Medicine and Biology, vol 525. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9194-2_17
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DOI: https://doi.org/10.1007/978-1-4419-9194-2_17
Publisher Name: Springer, Boston, MA
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