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Advances in Modelling and Clinical Application of Intravenous Anaesthesia pp 57–70Cite as

Clinical Application of Pharmacokinetic and Pharmacodynamic Models

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 523))

Abstract

Anaesthesiologists have a special interest in pharmacology, maybe even more than other physicians who prescribe drugs and often follow narrow approved dosing guidelines. Anaesthetic drugs can be administered in a wide dose range, with relative under dosage (awareness, muscle tension or pain) adequate dosage and relative over dosage (late recovery, side effects) all being observed within the approved dose range. The art, or the science, of the anaesthetist is to choose both the drug and the dose in order to achieve an adequate level of anaesthesia as fast as possible and maintain it just as long as necessary in any individual patient. Pharmacokinetic and pharmacodynamic modelling helps to achieve these clinical goals by differentiation within the dose-effect relationship into a dose-concentration relationship and a concentration-effect relationship. Clinically, kinetic-dynamic modelling can be used to adjust the dose to a desired level of effect at any time through target-controlled delivery systems.

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Author information

Authors and Affiliations

  1. Institut Gustave Roussy 39, Service d’Anesthésie, Rue C. Desmoulins, 94805, Villejuif, France

    Valerie Billard

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  1. Valerie Billard
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Editor information

Editors and Affiliations

  1. Leiden University Medical Centre, Leiden, The Netherlands

    Jaap Vuyk

  2. University of Ulm, Ulm, Germany

    Stefan Schraag

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Billard, V. (2003). Clinical Application of Pharmacokinetic and Pharmacodynamic Models. In: Vuyk, J., Schraag, S. (eds) Advances in Modelling and Clinical Application of Intravenous Anaesthesia. Advances in Experimental Medicine and Biology, vol 523. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9192-8_6

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  • DOI: https://doi.org/10.1007/978-1-4419-9192-8_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4830-6

  • Online ISBN: 978-1-4419-9192-8

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