Abstract
The ultimate aim of pharmacological research is to describe the dose-effect relationship of drugs. This relationship is difficult to describe because it is time dependent. A phase difference exists between the moment of administration of the drug and the observed effect. Furthermore, continuous measurement of the effect of a drug is not always possible. If blood concentrations of the drug can be measured then the dose-effect relationship is divided into a dose-concentration relationship (pharmacokinetics) and a concentration-effect relationship (pharmacodynamics).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J.A. Kuipers, F. Boer, E. Olofsen, J. G. Bovill and A. G. Burm, Recirculatory Pharmacokinetics and Pharmacodynamics of Rocuronium in Patients: The Influence of Cardiac Output. Anesthesiology; 94: 47–55 (2001)
W. L. Chiou, The phenomenon and rationale of marked dependence of drug concentration on blood sampling site: implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part I) Clin Pharmacokinet 17: 175–99 (1989)
D. R. Stanski, F. G. Mihm, M.H. Rosenthal and S.M. Kalman, Pharmacokinetics of high-dose thiopental used in cerebral resuscitation Anesthesiology 53: 169–71 (1980)
R. N. Boyes, D. B. Scott, PJ. Jebson, M. J. Godman and D. G. Juhan, Pharmacokinetics of lidocaine in man. Clin Pharmacol Then 12: 105–15; (1971)
P. O. Mitenko and R. I. Olgilvie. Rapidly achieved plasma concentrations plateaus with observations on theophylinne kinetics. Clin Pharmacol Ther; 13: 329–35 (1971)
T. Kazama, K. Ikeda, K. Morita and Y. Sanjo, Awakening Propofol Concentration with and without Blood-effect Site Equilibration after Short-term and Long-term Administration of Propofol and Fentanyl Anesthesia, Anesthesiology 88: 928–34 (1998)
J. Vuyk, T. Lim, F. H. M. Engbers, A. G. Burm, A. A. Vletter and J. G. Bovill, The pharmacodynamic interaction of propofol and alfentanil during lower abdominal surgery in women, Anesthesiology 83(1): 8–22 (1995)
S. L. Shafer and K. M. Gregg KM. Algorithms to rapidly achieve and maintain stable drug concentrations at the site of effect with a computer controlled infusion pump, J Pharmacokineti Biopharm 20: 147–167 (1992)
C.F. Minto, Th. W. Schmder, T. D. Egan, E. Youngs, H. J. Lemmens, P. L. Gambus, V. Billard, J. F. Hoke, K. H. Moore, D. J. Hermann, K. T. Muir, J. W. Mandema and S. L. Shafer. Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil: I. Model development, Anesthesiology 86: 10–23 (1997)
M. White, M. J. Schenkels and F. H. M. Engbers, Effect-site modelling of propofol using auditory evoked potentials, Br J Anaesth 82(3): 333–910 (1999)
M. A. Hughes, P. S. A. Glass and J. R. Jacobs, Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology; 76. 334–341 (1992)
J. F. Coetzee, J. B. Glen, C. A. Wium and L. Boshoff, Pharmacokinetic Model Selection for Target Controlled Infusions of Propofol. Anesthesiology 82: 1328–1345 (1995)
K. Zomorodi, A. Donner, J. Somma, J. Barr, R. Sladen, J. Ramsay, E. Geller, S.L. Sharer, Population pharmacokinetics of midazolam administered by target controlled infusion for sedation following coronary artery bypass grafting. Anesthesiology 89 (6): 1418–29 (1998)
D.R. Stanski and P.O. Maitre, Population pharmacokinetics and pharmacodynamics of thiopental:the effect of age revisited. Anesthesiology 72: 412–422 (1990).
P. O. Maitre, S. Vozeh, J. Heykants, D. A. Thomson and D. R. Stanski, Population pharmacokinetics of alfentanil: the average dose-plasma concentration relationship and interindividual variability in patients, Anesthesiology 66: 3–12 (1987)
S.L. Shafer, J.R. Varvel, Pharmacokinetics, pharmacodynamics, and rational opioid selection. Anesthesiology 74 (1): 53–63 (1991)
J.G. Bovill, P.S. Sebel, CL. Blackburn, CL. Oei-Lim, J.J. Heykants, The pharmacokinetics of sufentanil in surgical patients, Anesthesiology 61 (5): 502–6 (1984)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Engbers, F.H.M. (2003). Basic Pharmacokinetic Principles for Intravenous Anaesthesia. In: Vuyk, J., Schraag, S. (eds) Advances in Modelling and Clinical Application of Intravenous Anaesthesia. Advances in Experimental Medicine and Biology, vol 523. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9192-8_1
Download citation
DOI: https://doi.org/10.1007/978-1-4419-9192-8_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4830-6
Online ISBN: 978-1-4419-9192-8
eBook Packages: Springer Book Archive