OPG, RANKL, and RANK in Cancer Metastasis: Expression and Regulation

  • Julie M. Brown
  • Jian Zhang
  • Evan T. Keller
Part of the Cancer Treatment and Research book series (CTAR, volume 118)


In normal adult human bone, the skeleton is renewed on a continuous basis in a dynamic, highly regulated process known as the bone remodeling sequence. The synthesis of new bone by osteoblasts is consequent to the critical primary step of excavation of old bone (resorption or osteolysis) by large multinucleated osteoclasts. These processes are tightly coupled such that, in normal bone homeostasis, the formative and resorptive phases are balanced [reviewed in (Mundy, 1999)].


Bone Resorption Giant Cell Tumor Skeletal Metastasis Human Bone Marrow Stromal Cell Biophysical Research Communication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Julie M. Brown
    • 1
  • Jian Zhang
    • 2
  • Evan T. Keller
    • 2
  1. 1.UNSW Department of Clinical Medicine, Prince of Wales HospitalOncology Research CentreRandwickAustralia
  2. 2.Unit for Laboratory Animal Medicine and Department of PathologyUniversity of MichiganAnn ArborUSA

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