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Tissue-specific Expression of Two Peroxisomal 3-ketoacyl-CoA Thiolase Genes in Wild and PPARα-null Mice and Induction by Fenofibrate

  • Gregory Chevillard
  • Marie-Claude ClÉmencet
  • Philippe Etienne
  • Pascal Martin
  • Thierry Pineau
  • Norbert Latruffe
  • Valerie Nicolas-FrancÈs
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 544)

Abstract

Our laboratory cloned two peroxisomal 3-ketoacyl-CoA thiolase genes in mouse. These genes were named mThA (mouse peroxisomal Thiolase A) and mThB (mouse peroxisomal Thiolase B) by comparison with peroxisomal thiolase genes known in rat (Hijikata et al. 1990, Bodnar & Rachubinski, 1990). In this study, we analysed the tissue expression of the two thiolase genes on wild and on PPARa-null mice.

Keywords

Internal Medicine White Adipose Tissue Differential Regulation Tissue Expression Peroxisome Proliferators 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Hijikata M., Wen J-K., Osumi T. & Hashimoto T., 1990, Rat peroxisomal 3-ketoacyl-CoA thiolase gene. Occurrence of two closely related but differentially regulated genes. J. Biol Chem. 265:4600–4606.PubMedGoogle Scholar
  2. Bodnar A.G. & Rachubinski R.A., 1990, Cloning and sequencing determination of cDNA encoding a second rat liver peroxisomal 3-ketoacyl-CoA thiolase. Gene 91: 193–199.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Gregory Chevillard
    • 1
  • Marie-Claude ClÉmencet
    • 1
  • Philippe Etienne
    • 1
  • Pascal Martin
    • 2
  • Thierry Pineau
    • 2
  • Norbert Latruffe
    • 1
  • Valerie Nicolas-FrancÈs
    • 2
  1. 1.Laboratory of Molecular and Cellular Biology (GDR-CNRS n°2583)University of Burgundy, 6 Bd GabrielPittsburghFrance
  2. 2.Laboratory of Toxicology and Pharmacology, INRA, BP3Toulouse, Cedex 09France

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