Skip to main content

Regulation of Peroxisomal Genes by DHEA and Vitamin D

  • Conference paper
Peroxisomal Disorders and Regulation of Genes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 544))

Abstract

The aim of our study was to find factors that modify the phenotype of the normal peroxisomal compartment (number, size, shape, membrane proteins and enzyme content of the matrix) and/or the transcription and translation of genes involved in peroxisome biogenesis and function in normal wild-type cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baudhuin, P., Beaufay, H. and de Duve, C, 1964, Combined biochemical and morphological study of particulate fractions from rat liver. Analysis of preparations enriched in lysosomes or in particles containing urate oxidase, D-amino acid oxidase, and catalase. J. Cell Biol. 26: 219–243.

    Article  Google Scholar 

  • Chawla, A., Repa, J.J., Evans, R.M. and Mangelsdorf, D.J., 2001, Nuclear receptors and lipid physiology: opening the X-files. Science 294: 1866–1870.

    Article  PubMed  CAS  Google Scholar 

  • Davis, W.L., Matthews, J.L. and Goodman, D.B., 1989 Glyoxylate cycle in the rat liver: effect of vitamin D3 treatment. FASEB J. 3: 1651–1655.

    PubMed  CAS  Google Scholar 

  • Depreter, M., Nardacci, R., Tytgat, T., Espeel, M., Stefanini, S. and Roels, F., 1998, Maturation of the liver specific peroxisome versus laminin, collagen IV and integrin expression. Biol. Cell 90: 641–652.

    PubMed  CAS  Google Scholar 

  • Depreter, M., Vandesompele, J., Espeel, M., Speleman, F., Roels, F., 2002, Modulation of the peroxisomal gene expression pattern by dehydroepiandrosterone and vitamin D: therapeutic implications. J. Endocrinol. 175: 779–792.

    Article  PubMed  CAS  Google Scholar 

  • Depreter, M, Espeel, M. and Roels, F., 2003, Human Peroxisomal disorders. Microsc. Res. Techn. 61, in press.

    Google Scholar 

  • Frenkel, R.A., Slaughter, C.A., Orth, K., Moomaw, C.R., Hicks, S.H., Snyder, J.M., Bennett, M., Prough, R.A., Putnam, R.S. and Milewich, L.J., 1990, Peroxisome proliferation and induction of peroxisomal enzymes in mouse and rat liver by dehydroepiandrosterone feeding. Steroid Biochem. 35: 333–342.

    Article  CAS  Google Scholar 

  • Friess, E., Schiffelholz, T., Steckler, T., and Steiger, A., 2000, Dehydroepiandrosterone-a neurosteroid. Eur. J. Clin. Invest. 30: Supplement 3 46–50.

    Article  Google Scholar 

  • Hertz, R., Aurbach, R., Hashimoto, T. and Bar-Tana, J., 1991, Thyromimetic effect of peroxisomal proliferators in rat liver. Biochem. J. 274: 745–751.

    PubMed  CAS  Google Scholar 

  • Jiang, G., Nepomuceno, L., Hopkins, K. and Sladek, F.M., 1995, Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor defines a new subclass of nuclear receptors. Mol. Cell. Biol. 15: 5131–543.

    PubMed  CAS  Google Scholar 

  • Kasperk, C.H., Wakley, G.K., Hierl, T. and Ziegler, R., 1997, Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro. J. Bone Mineral Res. 12: 464–471.

    Article  CAS  Google Scholar 

  • Leighton, B., Tagliaferro, A.R. and Newsholme, E.A., 1987, The effect of dehydroepiandrosterone acetate on liver peroxisomal enzyme activities of male and female rats. J.Nutr. 117:1287–1290.

    PubMed  CAS  Google Scholar 

  • Mangelsdorf, D.J. and Evans, R.M., 1995, The RXR heterodimers and orphan receptors. Cell 83: 841–850.

    Article  PubMed  CAS  Google Scholar 

  • Milewich, L., Catalina, F. and Bennett, M. 1995, Pleotropic effects of dietary DHEA. Ann. N- YAcad. Sci. 774 : 149–170.

    Article  CAS  Google Scholar 

  • Peters, J.M., Zhou, Y.C., Ram, P.A., Lee, S.S.T., Gonzalez, F.J. and Waxman, D.J., 1996, Peroxisome proliferator activated receptor â–¡ required for gene induction by dehydroepiandrosterone-3beta-sulfate. Molec. Pharmacol. 50: 67–74.

    CAS  Google Scholar 

  • Powers, J.M., Moser, H.W., Moser, A.B., Upshur, J.K., Bradford, B.F., Pai, S.G., Koda, P.H., Frias, J., and Tiffany, C, 1985, Fetal cerebrohepatorenal (Zellweger) syndrome: dysmorphic, radiologic, biochemical, and pathologic findings on four affected fetuses. Hum. Pathol. 16: 610–620.

    Article  PubMed  CAS  Google Scholar 

  • Prough, R.A., Webb, S.J., Wu, H.Q., Lapenson D.P. and Waxman D.J., 1994, Induction of microsomal and peroxisomal enzymes by dehydroepiandrosterone and its reduced metabolite in rats. Cancer res. 54: 2878–2886.

    PubMed  CAS  Google Scholar 

  • Roels, F., De Prest, B., and De Pestel, G., 1995, Liver and chorion cytochemistry. J. Inherit. Metab. Dis. 18:Suppl 1 pp 155–171.

    Google Scholar 

  • Vandesompele, J., De Paepe, A. and Speleman, F., 2002a, Elimination of primer-dimer artifacts and genomic coamplification using a two-step SYBR Green I real-time RT-PCR.Anal. Biochem. 303:95–98.

    Article  CAS  Google Scholar 

  • Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A. and Speleman, F., 2002b, Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. GenomeBiol 18: 3, R0034.1–11

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this paper

Cite this paper

Depreter, M., Vandesompele, J., Ferdinandusse, S., Speleman, F., Roels, F. (2003). Regulation of Peroxisomal Genes by DHEA and Vitamin D. In: Roels, F., Baes, M., De Bie, S. (eds) Peroxisomal Disorders and Regulation of Genes. Advances in Experimental Medicine and Biology, vol 544. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9072-3_29

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-9072-3_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4782-8

  • Online ISBN: 978-1-4419-9072-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics