Gastritis and Gastropathies of Childhood

  • James E. Dimmick
  • Gareth P. Jevon


A skilled pediatric gastroenterologist with a flexible endoscope can thoroughly inspect and perform a biopsy in the duodenum, esophagus, and all zones of the stomach. That skill, with astute observation of gross anatomy of the stomach, combined with interpretative abilities of an experienced histopathologist, is the most assured way of defining pediatric gastropathies.


Celiac Disease Lamina Propria Intestinal Metaplasia Chronic Granulomatous Disease Eosinophilic Gastroenteritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Owen D. Normal histology of the stomach. Am J Surg Pathol. 1986;10:48–61.PubMedGoogle Scholar
  2. 2.
    Ellison E, Hassall E, Dimmick J. Mucin histochemistry of the developing gastroesophageal junction. Pediatr Pathol Lab Med. 1996;16:195–206.PubMedGoogle Scholar
  3. 3.
    Popiolek D, Kahn E, Markowitz J, Daum F. Prevalence and pathogenesis of pancreatic acinar tissue at the gastroesophageal junction in children and young adults. Arch Pathol Lab Med. 2000;124:1165–1167.PubMedGoogle Scholar
  4. 4.
    Integlia M, Krishnamurthy S, Berhane R, et al. Pancreatic metaplasia of the gastric mucosa in pediatric patients. Am J Gastroenterol. 1997;92:1553–1556.PubMedGoogle Scholar
  5. 5.
    Oberg S, Peters J, DeMeester T, et al. Inflammation and specialized intestinal metaplasia of cardiac mucosa is a manifestation of gastroesophageal reflux disease. Ann Surg. 1997;226:522–532.PubMedGoogle Scholar
  6. 6.
    Chandrasoma P, Der R, Yanling M, et al. Histology of the gastroesophageal junction: an autopsy study. Am f Surg Pathol. 2000;24:402–409.Google Scholar
  7. 7.
    Kilgore S, Ormsby A, Gramlich T, et al. The gastric cardia: fact or fiction? Am J Gastroenterol. 2000;95:921–924.PubMedGoogle Scholar
  8. 8.
    Zhou H, Greco M, Kahn E. Origin of cardiac mucosa: ontogenic considerations. Mod Pathol. 1999;12:499A.Google Scholar
  9. 9.
    Jevon G, Dimmick J. Gastritis in children: a classification and appraisal. Mod Pathol. 1995;8:4P.Google Scholar
  10. 10.
    Jevon G, Dimmick J, Dohil R, Hassall E. Spectrum of gastritis in celiac disease in childhood. Pediatr Dev Pathol. 1999;2:221–226.PubMedGoogle Scholar
  11. 11.
    Ashorne M, Ruuska T, Karikoski R, et al. Gastric mucosal cell densities in Helicobacter pylori positive and negative dyspeptic children and healthy controls. J Pediatr Gastroenterol Nutr. 1994;18:146–154.Google Scholar
  12. 12.
    De Giacomo C, Gianatti A, Negrini R, et al. Lymphocytic gastritis: a positive relationship with celiac disease. J Pedatr. 1994; 124:57–62.Google Scholar
  13. 13.
    Goldman H, Proujansky R. Allergic proctitis and gastroenteritis in children. Am J Surg Pathol. 1986;10:75–86.PubMedGoogle Scholar
  14. 14.
    Whittington P, Whittington G. Eosinophilic gastroenteropathy in childhood. J Pediatr Gastroenterol Nutr. 1988;7:379–386.Google Scholar
  15. 15.
    Black D, Haggitt R, Whittington P. Gastroduodenal endoscopichistologic correlation in pediatric patients. J Pediatr Gastroenterol Nutr. 1988;7:353–358.PubMedGoogle Scholar
  16. 16.
    Carpenter H, Talley N. Gastroscopy is incomplete without biopsy. Clinical relevance of distinguishing gastropathy from gastritis. Gastroenterology. 1995;108:917–924.PubMedGoogle Scholar
  17. 17.
    Genta R, Robason G, Graham D. Simultaneous visualization of Helicobacter pylori and gastric morphology: a new stain. Hum Pathol. 1994;25:221–226.PubMedGoogle Scholar
  18. 18.
    Eshun J, Black D, Casteel H, et al. Comparison of immunohistochemistry and silver stain for the diagnosis of pediatric Helicobacter pylori infection in urease-negative gastric biopsies. Pediatr Dev Pathol. 2001;4:82–88.PubMedGoogle Scholar
  19. 19.
    Madani S, Rabah R, Tolia V. Diagnosis of Helicobacter pylori infection from antral biopsies in pediatric patients is urease test reliable? Dig Dis Sci. 2000;45:1233–1237.PubMedGoogle Scholar
  20. 20.
    Dixin M, Genta R, Yardley J, Correa P, et al. The updated Sydney system. Am f Surg Pathol. 1996;20:1161–1181.Google Scholar
  21. 21.
    Dimmick J, Jevon G, Hassall E. Pediatric gastritis. Persp Pediatr Pathol. 1997;20:35–76.Google Scholar
  22. 22.
    Dohil R, Hassall E, Jevon G, Dimmick J. Gastritis and gastropathy of childhood. J Pediatr Gastroenterol Nutr. 1999;29:378–394.PubMedGoogle Scholar
  23. 23.
    Oguzkurt P, Talim B, Tanyel F, et al. The role of heterotopic gastric mucosa with or without colonization of Helicobacter pylori upon the diverse symptomatology of Meckel’s diverticulum in children. Turkish J Pediatr. 2001;43:312–316.Google Scholar
  24. 24.
    Faller G, Winter M, Steininger H, et al. Antigastric autoantibodies and gastric secretory function in Helicobacter pylori-infected patients with duodenal ulcer and non-ulcer dyspepsia. Scand J Gastroenterol. 1998;33:276–282.PubMedGoogle Scholar
  25. 25.
    Kaptan K, Beyan C, Ural A, et al. Helicobacter pylori-is it a novel causative agent in vitamin B12 deficiency? Arch Intern Med. 2000;160:1349–1353.PubMedGoogle Scholar
  26. 26.
    Editorial. Links between Helicobacter pylori infection cobalamin deficiency and pernicious anemia. Arch Intern Med. 2000;160:1229–1230.Google Scholar
  27. 27.
    Imrie C, Rowland M, Bourke B, Drumm B. Is Helicobacter pylori infection in childhood a risk factor for gastric cancer? Pediatrics. 2001;107:373–380.PubMedGoogle Scholar
  28. 28.
    Nardone G, Staibano S, Rocco A, et al. Effect of Helicobacter pylori infection on gastric cell proliferation and genomic instability in a pediatric population of southern Italy. Dig Liver Dis. 2001;33:743–749.PubMedGoogle Scholar
  29. 29.
    Uc A, Chong S. Treatment of Helicobacter pylori gastritis improves dyspeptic symptoms in children. J Pediatr Gastrenterol Nutr. 2002;34:281–285.Google Scholar
  30. 30.
    Ozen H, Dinier G, Akyon Y, et al. Helicobacter pylori infection and recurrent abdominal pain in Turkish children. Helicobacter. 2001;6:234–238.PubMedGoogle Scholar
  31. 31.
    Talley N, Vakil N, Ballard E, Fennerty M. Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia. N Engl J Med. 1999;341:1106-1011.Google Scholar
  32. 32.
    Stringer V, Puntis J, Batcup G, Dixon M. Gastroduodenal ulcers in the Helicobacter pylori era. Acta Paediatrica. 2000;89:1181–1185.PubMedGoogle Scholar
  33. 33.
    Dohil, R. Hassall E. Peptic ulcer disease in children. Best Pract Res Clin Gastroenterol. 2000;14:53–73.Google Scholar
  34. 34.
    Hassall E, Dohil R, Dimmick J.H. pylori negative (idiopathic) duodenal ulcer disease (DUD) in children is a different disease from HP positive DUD. Gastroenterol. 2002;122:A548.Google Scholar
  35. 35.
    Ernst P, Crowe S, Reyes V. How does Helicobacter pylori cause mucosal damage? The inflammatory response. Gastroenterology. 1997;113:535–542.Google Scholar
  36. 36.
    Luzza F, Parrello T, Sebkova L, et al. Expression of proinflammatory and Thl but not Th2 cytokines is enhanced in gastris mucosa of Helicobacter pylori infected children. Dig Liver Disease. 2001;33:14–20.Google Scholar
  37. 37.
    Nogueira C, Figueiredo C, Carneiro F, et al. Helicobacter pylori genotypes may determine gastric histopathology. Am J Pathol. 2001;158:647–654.PubMedGoogle Scholar
  38. 38.
    Alarcon T, Martinez M, Urruzuno P, et al. iPrevalence of CagA and VacA antibodies in children with Helicobacter pylori-associated peptic ulcer compared to prevalence in pediatric patients with active and nonactive gastritis. Clin Diag Lab Immunol. 2000;7:842–844.Google Scholar
  39. 39.
    Yahav J, Fradkin A, Weisselberg B, et al. Relevance of CagA positivity to clinical course of Helicobacter pylori infection in children. J Clin Microbiol. 2000;38:3534–3537.PubMedGoogle Scholar
  40. 40.
    Luzza F, Pensabene L, Imeneo M, et al. Antral nodularity and positive CagA serology are distinct and relevant markers of severe gastric inflammation in children with Helicobacter pylori infection. Helicobacter. 2002;7:46–52.PubMedGoogle Scholar
  41. 41.
    Warren R. Gastric pathology associated with Helicobacter pylori. Gastroenterol Clin. 2000;29:1–22.Google Scholar
  42. 42.
    Hiruki T, Dimmick J, Hassall E. Gastric metaplasia in duodenal biopsies of pediatric patients with Helicobacter gastritis: a case control study. Lab Invest. 1993;68:4P.Google Scholar
  43. 43.
    Mitchell J, Mitchell M, Tobias V. Acute Helicobacter pylori infection in an infant associated with gastric ulceration and serological evidence of intrafamilial transmission. Am f Gastroenterol. 1992;87:382–386.Google Scholar
  44. 44.
    Rocha G, Queiroz D, Mendes E, et al. Helicobacter pylori acute gastritis: histologic endoscopic clinical and therapeutic features. Am J Gastroenterol. 1991;86:1592–1595.PubMedGoogle Scholar
  45. 45.
    Sobala G, Crabtree J, Dixon M, et al. Acute Helicobacter pylori infection: clinical features local and systemic immune response, gastric mucosal histology and gastric juice ascorbic acid concentrations. Gut. 1991;32:1415–1418.PubMedGoogle Scholar
  46. 46.
    Hassall E, Dimmick J. Unique features of Helicobacter pylori disease in children. Dig Dis Sci. 1991;36:417–423.PubMedGoogle Scholar
  47. 47.
    Carpentieri D, Wenner W, Liquornik K, Ruchelli E. Significance of lymphoid follicles and aggregates in gastric mucosa of children. Ped Dev Pathol. 2000;3:177–179.Google Scholar
  48. 48.
    Luzza F, Pensabene L, Imeneo M, et al. Antral nodularity identifies children infected with Helicobacter pylori with higher grades of gastric inflammation. Gastrointest Endosc. 2001;53:60–64.PubMedGoogle Scholar
  49. 49.
    Riddell R. Pathobiology of Helicobacter pylori infection in children. Can J Gastroenterol. 1999;13:599–603.PubMedGoogle Scholar
  50. 50.
    Whitney A, Guarner J, Hutwagner L, Gold B. Helicobacter pylori gastritis in children and adults: comparative histopathologic study. Am Diag Pathol. 2000;4:279–285.Google Scholar
  51. 51.
    Yamada M, Sumazaki R, Adachi H, et al. Resolution of proteinlosing hypertrophic gastropathy by eradication of Helicobacter pylori. Eur f Pediatr. 1997;156:182–185.Google Scholar
  52. 52.
    Rauws E, Langenberg W, Houthoff H, et al. Campylobacter-pylorides-associated chronic antral gastritis. Gastroenterology. 1988;94:33–40.PubMedGoogle Scholar
  53. 53.
    Genta R, Lew G, Graham D. Changes in gastric mucosa following eradication of Helicobacter pylori. Mod Pathol. 1993;6:281–289.PubMedGoogle Scholar
  54. 54.
    Tepes B, Kavcic B, Zaletel L, et al. Two-to four-year histological follow-up of gastric mucosa after Helicobacter pylori eradication. J Pathol. 1999;188:24–29.PubMedGoogle Scholar
  55. 55.
    Forbes G, Warren R, Glasser M, et al. Long-term follow-up of gastric histology after Helicobacter pylori eradication. J Gastroenterol Hepatol. 1996;11:670–673.PubMedGoogle Scholar
  56. 56.
    Genta R. Helicobacter pylori inflammation mucosal damage and apoptosis: pathogenesis and definition of gastric atrophy. Gastroenterology. 1997;113:S51–S55.PubMedGoogle Scholar
  57. 57.
    Moayyedi P, Wason C, Peacock R, et al. Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression. Helicobacter. 2000;4:206–214.Google Scholar
  58. 58.
    Voutilainen M, Farkikila M, Mecklin J-P, et al. Chronic inflammation at the gastroesophageal junction (carditis) appears to be a specific finding related to Helicobacter pylori infection and gastroesophageal reflux disease. Am J Gastroenterol. 1999;94:3175–3180.PubMedGoogle Scholar
  59. 59.
    Morini S, Zullo A, Hassan C, et al. Gastric cardia inflammation: role of Helicobacter pylori infection and symptoms of gastroesophageal reflux disease. Am J Gastroenterol. 2001;96:2337–2340.PubMedGoogle Scholar
  60. 60.
    Kuipers E, Uyterlind A, Pena A, et al. Long-term sequelae of Helicobacter pylori infection. Lancet. 1995;345:1525–1528.PubMedGoogle Scholar
  61. 61.
    Endo S, Ohkusa T, Saito Y, et al. Detection of Helicobacter pylori infection in early stage gastric cancer; a comparison between intestinal-and diffuse-type gastric adenocarcinoma. Cancer. 1995;75:2203–2208.PubMedGoogle Scholar
  62. 62.
    Roggero E, Zucca E, Pinotti G, et al. Eradication of Helicobacter pylori in primary low-grade lymphoma of mucosa-associated lymphoid tissue. Ann Intern Med. 1995; 122:767–769.PubMedGoogle Scholar
  63. 63.
    Graham D. Benefits from elimination of Helicobacter pylori infection include major reduction in the incidence of peptic ulcer disease, gastric cancer and primary gastric lymphoma. Prev Med. 1994;23:712–716.PubMedGoogle Scholar
  64. 64.
    Hussell T, Isaacson P, Crabtree J, Spencer J. The response of cells from low-grade B-cell lymphoma of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet. 1993;342:571–574.PubMedGoogle Scholar
  65. 65.
    Wotherspoon A, Doglioni C, Diss T, et al. Regression of primary low-grade B-cell lymphoma of mucosa-associated lymphoid tissue after eradication of Helicobacter pylori. Lancet. 1993;342:575–577.PubMedGoogle Scholar
  66. 66.
    Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345:784–789.PubMedGoogle Scholar
  67. 67.
    Lavelle J, Landas S, Mitros F, Conklin J. Acute gastritis associated with spiral organisms from cat. Dig Dis Sci. 1994;39:744–750.PubMedGoogle Scholar
  68. 68.
    al-Himyary A, Zabaneh R, Zabaneh S, Barnett S. Gastrospirillum hominis. South Med J. 1994;87:1147–1150.PubMedGoogle Scholar
  69. 69.
    Solnick J, O’Rourke J, Lee A, Tomkins L. Molecular analysis of urease genes from a newly identified uncultured species of Helicobacter. Infect Immun. 1994;62:1631–1638.PubMedGoogle Scholar
  70. 70.
    Oliva M, Lazenby A, Perman J. Gastritis associated with Gastrospirillum hominis in children. Comparison with Helicobacter pylori and review of the literature. Mod Pathol. 1993;6:513–515.PubMedGoogle Scholar
  71. 71.
    Debongnie J, Donnay M, Mairesse J. Gastrospirillum (Helicobacter heilmannii): a cause of gastritis sometimes transient better diagnosed by touch cytology? Am J Gastroenterol. 1995; 90:411–416.PubMedGoogle Scholar
  72. 72.
    Akin O, Tsou V, Werner A. Gastrospirillum hominis associated chronic active gastritis. Pediatr Pathol Lab Med. 1995;15:429–435.PubMedGoogle Scholar
  73. 73.
    Yall Z, Yamada N, Wen M, et al. Gastrospirillum hominis and Helicobacter pylori infection in Thai individual; comparison of histopathological changes of gastric mucosa. Pathol Int. 1998;48:507–511.Google Scholar
  74. 74.
    Mention K, Michaud L, Guimber D, et al. Characteristics and prevalence of Helicobacter heilmannii in children undergoing upper gastrointestinal endoscopy. J Pediatr Gastroenterol Nutr. 1999;29:533–539.PubMedGoogle Scholar
  75. 75.
    Stolte M, Kroher G, Meining A, et al. A comparison of Helicobacter pylori and H. heilmannii gastritis. A matched control study involving 404 patients. Scand J Gastroenterol. 1997;32:28–33.PubMedGoogle Scholar
  76. 76.
    Ierardi E, Monno R, Francavilla R, et al. Helicobacter heilmannii gastritis: a histological and immunohistochemical trait. J Clin Pathol. 2001;54:774–777.PubMedGoogle Scholar
  77. 77.
    Svec A, Kordas P, Pavlis Z, Novotny J. High prevalence of Helicobacter heilmannii-associated gastritis in a small predominately rural area: further evidence in support of a zoonosis? Scand J Gastroenterol. 2000;35:925–928.PubMedGoogle Scholar
  78. 78.
    Qualman S, Hamoudi A. Pediatric hypertrophic gastropathy (Menetrier’s disease). Pediatr Pathol. 1992;12:263–267.PubMedGoogle Scholar
  79. 79.
    Leonidas J, Beatty E, Wenner H. Menetrier disease and cytomegalovirus infection in children. Am J Dis Child. 1973; 126:806–808.PubMedGoogle Scholar
  80. 80.
    Kovacs A, Churchill M, Wood D, et al. Molecular and epidemiologic evaluations of a cluster of cases of Menetrier disease associated with cytomegalovirus. Pediatr Infect Dis J. 1993; 12: 1011–1014.PubMedGoogle Scholar
  81. 81.
    Sferra T, Pawel B, Qualman S, Li B. Menetrier disease of childhood: role of cytomegalovirus and transforming factor alpha. J Pediatr. 1996;128:213–219.PubMedGoogle Scholar
  82. 82.
    Takagi H, Jhappan C, Sharp R, Merlino G. Hypertrophic gastropathy resembling Menetrier disease in transgenic mice overexpressing transforming growth factor alpha in the stomach. J Clin Invest. 1992;90:1161–1167.PubMedGoogle Scholar
  83. 83.
    Dempsey P, Goldenring J, Soroka C, et al. Possible role of transforming growth factor alpha in the pathogenesis of Menetrier disease; supportive evidence from humans and transgenic mice. Gastroenterology. 1992; 103:1950–1963.PubMedGoogle Scholar
  84. 84.
    Ikeda K, Kumashiro R, Kifune T. Nine cases of acute Aniskiaisis. Gastrointest Endosc. 1989;35:304–308.PubMedGoogle Scholar
  85. 85.
    del Pozo V, Arrieta I, Tunon T, et al. Immunopathogenesis of human gastrointestinal infection by Anisakis simplex. J Allergy Clin Immun. 1999;104:637–643.PubMedGoogle Scholar
  86. 86.
    Esteve C, Resano A, Diaz-Tejeiro P, Fernandez-Benitez M. Eosinophilic gastritis due to Anisakis; a case report. Allergologia Immunopathol. 2000;28:21–23.Google Scholar
  87. 87.
    Oberhuber G, Kastner N, Stolte M. Giardiasis: a histologic analysis of 567 cases. Scand J Gastroenterol. 1997;32:48–51.PubMedGoogle Scholar
  88. 88.
    Doglioni C, De Boni M, Cielo R, et al. Gastric giardiasis. J Clin Pathol. 1992;45:964–967.PubMedGoogle Scholar
  89. 89.
    Michalak D, Cooney D, Rhodes K, et al. Gastrointestinal mucormycoses in infants and children: a cause of gangrenous intestinal cellulitis and perforation. J Pediatr Surg. 1980;15:320–324.PubMedGoogle Scholar
  90. 90.
    Fyfe B, Poppiti R, Lubin J, Robinson M. Gastric syphilis: primary diagnosis by biopsy: report of 4 cases. Arch Pathol Lab Med. 1993;117:820–823.PubMedGoogle Scholar
  91. 91.
    Greenstein D, Wilcox C, Schwartz D. Gastric syphilis: report of 7 cases and review of the literature. J Clin Gastroenterol. 1994; 18:4–9.PubMedGoogle Scholar
  92. 92.
    Rowen M, Myers M, Williamson R. Emphysematous gastritis in a leukemic child. Med Pediatr Oncol. 1976;2:433–437.PubMedGoogle Scholar
  93. 93.
    Baker C, Gilsdorf J, South M, Singleton E. Gastritis as a complication of varicella. South Med J. 1973;66:539–541.PubMedGoogle Scholar
  94. 94.
    Alsaigh N, Odze R, Goldman H, et al. Gastric and esophageal intraepithelial lymphocytes in pediatric celiac disease. Am J Surg Pathol. 1996;20:865–870.PubMedGoogle Scholar
  95. 95.
    Haot J, Wallez L, Jouret-Mourin A, Hardy N. La gastrite a lymphoctes: une nouvelle entite? Acta Endosc. 1985;15:187–188.Google Scholar
  96. 96.
    Wolber R, Owen D, Del Buono L, et al. Lymphocytic gastritis in patients with celiac sprue or sprue like intestinal disease. Gastroenterology. 1990;98:310–315.PubMedGoogle Scholar
  97. 97.
    Hayat M, Arora D, Wyatt J, et al. The pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence of duodenal pathology. J Clin Pathol. 1999;52:815–819.PubMedGoogle Scholar
  98. 98.
    Wu T-T, Hamilton S. Lymphocytic gastritis: association with etiology and topology. Am J Surg Pathol. 1999;23:153–158.PubMedGoogle Scholar
  99. 99.
    Caporali R, Luciano S. Diffuse varioliform gastritis. Arch Dis Child. 1986;61:405–407.PubMedGoogle Scholar
  100. 100.
    Couper R, Laski B, Drumm B, et al. Chronic varioliform gastritis in childhood. J Pediatr. 1989;115:441–444.PubMedGoogle Scholar
  101. 101.
    Vinograd I, Granot E, Ron N, et al. Chronic diffuse varioliform gastritis in a child: total gastrectomy for acute massive bleeding. J Clin Gastroenterol. 1993;16:40–44.PubMedGoogle Scholar
  102. 102.
    Tomomasa T, Hsu J, Itoh K, Kuroume T. Endoscopic findings in pediatric patients with Henoch Schonlein purpura and gastrointestinal symptoms. J Pediatr Gastroenterol Nutr. 1987;6: 725–729.PubMedGoogle Scholar
  103. 103.
    Lillibridge C, Brandborg L, Rubin C. Childhood pernicious anemia. Gastroenterology. 1967;52:792–809.PubMedGoogle Scholar
  104. 104.
    Vaterlaws A. Gastric atrophy in childhood. Arch Dis Child. 1969;44:710–714.PubMedGoogle Scholar
  105. 105.
    Hayes D, Martin J, O’Brien T. Pernicious anemia with atrophic gastritis in a 17 year old boy. South Med J. 1970;63:429–431.PubMedGoogle Scholar
  106. 106.
    Kuitinen P, Maenpaa J, Krohn K, Visakorpi J. Gastrointestinal findings in autoimmune thyroiditis and nongoitrous juvenile hypothroidism in children. Scand f Gastroenterol. 1971;6:335–341.Google Scholar
  107. 107.
    Sanchez V, Latorre S. Pediatric gastritis. Gastroenterology. 1978;74:642.Google Scholar
  108. 108.
    Negrini R, Savio A, Appelmelk B. Autoantibodies to gastric mucosa in Helicobacter pylori infection. Helicobacter. 1997; 2(suppl):S13–S16.PubMedGoogle Scholar
  109. 109.
    Kolho K, Jusufovic J, Miettinen A, et al. Parietal cell antibodies and Helicobacter pylori in children. J Pediatr Gastroenterol Nutr. 2000;30:265–268.PubMedGoogle Scholar
  110. 110.
    Konrad E, Meister P. Fatal eosinophilic gastroenteritis in a two year old child. Virchows Arch Pathol Anat Histol. 1979;382:347–353.Google Scholar
  111. 111.
    Caldwell J, Sharma H, Hurtubise P, Colwell D. Eosinophilic gastroenteritis in extreme allergy: immunopathologic comparison with nonallergic gastrointestinal disease. Gastroenterology. 1979;77:560–564.PubMedGoogle Scholar
  112. 112.
    De Schryver-Kecskemeti K, Klouse R. A previously unrecognized subgroup of eosinophilic gastroenteritis. Am J Surg Pathol. 1984;8:171–180.Google Scholar
  113. 113.
    El Mouzan M, Al Quorian A, Anim J. Cow’s milk induced erosive gastritis in an infant. J Pediatr Gastroenterol Nutr. 1990; 10:1111–1113.Google Scholar
  114. 114.
    Soello-Ramirez P, Larrosa-Haro A. Gastrointestinal occult hemorrhage and gastroduodenitis in cow’s milk protein intolerance. J Pediatr Gastroenterol Nutr. 1984;3:215–218.Google Scholar
  115. 115.
    Katz A, Goldman H, Grand R. Gastric mucosal biopsy in eosinophilic (allergic] gastroenteritis. Gastroenterology. 1977; 73:705–709.PubMedGoogle Scholar
  116. 116.
    Deslandres C, Russo P, Gould P, Hardy P. Perforated duodenal ulcer in a pediatric patient with eosinophilic gastroenteritis. Can J Gastroenterol. 1997;11:208–212.PubMedGoogle Scholar
  117. 117.
    Khan S, Orenstein S. Eosinophilic gastroenteritis masquerading as pyloric stenosis. Clin Pediatr. 2000;39:55–57.Google Scholar
  118. 118.
    Dhawan A, Seemayer T, Pinsinski C, et al. Posttransplant eosinophilic gastroenteritis in children. Liver Transpl Surg. 1997;3:591–593.PubMedGoogle Scholar
  119. 119.
    Kelly K. Eosinophilic gastroenteritis. J Pediatr Gastroenterol Nutr. 2000;30(suppl):S28–S35.PubMedGoogle Scholar
  120. 120.
    Vanderhoof J, Young R. Allergic disorders of the gastrointestinal tract. Curr Opin Clin Nutr Metab Care. 2001;4:553–556.PubMedGoogle Scholar
  121. 121.
    Klein N, Hargrove R, Sleisenger M, Jeffries G. Eosinophilic gastroenteritis. Medicine. 1970;49:299–319.PubMedGoogle Scholar
  122. 122.
    Russo P, Doyon J, Sonsino E, et al. A congenital anomaly of vitamin B12 metabolism: a study of 3 cases. Hum Pathol. 1992;23:504–512.PubMedGoogle Scholar
  123. 123.
    Griscom N, Kirkpatrick J, Girdany B, et al. Gastric antral narrowing in chronic granulomatous disease of childhood. Pediatrics. 1974;54:456–460.PubMedGoogle Scholar
  124. 124.
    Mulholland M, Delaney J, Simmons R. Gastrointestinal complications of chronic granulomatous disease: surgical implications. Surgery. 1983;94:569–575.PubMedGoogle Scholar
  125. 125.
    Smith F, Taves D. Gastrointestinal involvement in chronic granulomatous disease of childhood. Can Assoc Radiol J. 1992;43:215–217.PubMedGoogle Scholar
  126. 126.
    Dickerman J, Colleti R, Tampas J. Gastric outlet obstruction in chronic granulomatous disease of childhood. Am J Dis Child. 1986;140:567–570.PubMedGoogle Scholar
  127. 127.
    Iannicelli E, Matrunola M, Almberger M, et al. Chronic granulomatous disease with gastric antral narrowing: a study and followup by MRI. Eur Radiol. 2001;11:1259–1262.PubMedGoogle Scholar
  128. 128.
    Ectors N, Dixon M, Geboes K, et al. Granulomatous gastritis: a morphological and diagnostic approach. Histopathology. 1993; 23:55–61.PubMedGoogle Scholar
  129. 129.
    Groisman G, Rosh J, Harpaz N. Langerhans cell histiocytosis of the stomach: a cause of granulomatousa gastritis and gastric polyposis. Arch Pathol Lab Med. 1994;118:1232–1235.PubMedGoogle Scholar
  130. 130.
    Hirsch B, Whittington P, Kirschner B, et al. Isolated granulomatous gastritis in an adolescent. Dig Dis Sci. 1989;292–296.Google Scholar
  131. 131.
    Haggitt R, Meissner W. Crohn’s disease of the upper gastrointestinal tract. Am J Clin Pathol. 1973;59:613–622.PubMedGoogle Scholar
  132. 132.
    Baudin D, De Costa L, Prentice R, Beck I. Crohn’s disease of the stomach: a case report and review of the literature. Dig Dis. 1973;18:623–629.Google Scholar
  133. 133.
    Lenaerts C, Roy C, Vaillencourt M, et al. High incidence of upper gastrointestinal tract involvement in children with Crohn’s disease. Pediatrics. 1989;83:777–781.PubMedGoogle Scholar
  134. 134.
    Griffiths A, Alemayehu E, Sherman P. Clinical features of gastroduodenal Crohn’s disease in adolescents. J Pediatr Gastroenterol Nutr. 1989;8:166–171.PubMedGoogle Scholar
  135. 135.
    Mashako M, Cezard J, Navarro J, et al. Crohn’s disease in the upper gastrointestinal tract. J Pediatr Gastroenterol Nutr. 1989;8:442–446.PubMedGoogle Scholar
  136. 136.
    Schmidt-Sommerfeld E, Kirschner B, Stephens J. Endoscopic and histologic findings in the upper gastrointestinal tract of children with Crohn’s disease. J Pediatr Gastroenterol Nutr. 1990; 11: 448–454.PubMedGoogle Scholar
  137. 137.
    Wright C, Riddell R. Histology of the stomach and duodenum in Crohn’s disease. Am J Surg Pathol. 1998;22:383–390.PubMedGoogle Scholar
  138. 138.
    Oberhuber G, Puspok A, Oesterreicher C, et al. Focally enhanced gastritis: a frequent type of gastritis in patients with Crohn’s disease. Gastroenterology. 1997;112:698–706.PubMedGoogle Scholar
  139. 139.
    Tobin J, Sinha B, Ramani P, et al. Upper gastrointestinal mucosal disease in pediatric Crohn disease and ulcerative colitis; a blinded controlled study. J Pediatr Gastroenterol Nutr. 2001;32:443–448.PubMedGoogle Scholar
  140. 140.
    Alcantara M, Rodriguez R, Potenciano J, et al. Endoscopic and bioptic findings in the upper gastrointestinal tract in patients with Crohn’s disease. Endoscopy. 1993;25:282–286.PubMedGoogle Scholar
  141. 141.
    Berrebi D, Besnard M, Fromont-Hankard G, et al. Interlekin-12 expression is focally enhanced in the gastric mucosa of pediatric patients with Crohn’s disease. Am J Pathol. 1998;152:667–672.PubMedGoogle Scholar
  142. 142.
    Kaufman S, Vanderhoof J, Young R, et al. Gastroenteric inflammation in children with ulcerative colitis. Am J Gastroenterol. 1997;92:1209–1212.PubMedGoogle Scholar
  143. 143.
    Ruuska T, Vaajalahti P, Arajauvi P, et al. Evaluation of upper gastrointestinal mucosal lesions in children with ulcerative colitis and Crohn’s disease. J Pediatr Gastroenterol Nutr. 1994; 19:181–186.PubMedGoogle Scholar
  144. 144.
    Sasaki M, Okada K, Koyama S, et al. Ulcerative colitis complicated by gastroduodenal lesions. J Gastroenterol. 1996;31:585–589.PubMedGoogle Scholar
  145. 145.
    Colleti R, Trainer T. Collagenous gastritis. Gastroenterology. 1989;97:1552–1555.Google Scholar
  146. 146.
    Cote J, Hankard G, Faure C, et al. Collagenous gastritis revealed by severe anemia in a child. Hum Pathol. 1998;29:883–886.PubMedGoogle Scholar
  147. 147.
    Pulimood A, Ramakrishna B, Mathan M. Collagenous gastritis and collagenous colitis: a report with sequential histological and ultrastructural findings. Gut. 1999;44:881–885.PubMedGoogle Scholar
  148. 148.
    Vesoulis Z, Lozanski G, Ravichandran P, Esber E. Collagenous gastritis: a case report morphologic evaluation and review. Mod Pathol. 2000;13:591–596.PubMedGoogle Scholar
  149. 149.
    Lagorce-Pages C, Fabiani B, Bouvier R, et al. Collagenous gastritis: a report of six cases. Am J Surg Pathol. 2001;25:1174–1179.PubMedGoogle Scholar
  150. 150.
    Ménétrier R. Des poly adénomes gastriques et de leur rapport avec le cancer de l’estomac. Arch Physiol Norm Pathol. 1888;1:32–35.Google Scholar
  151. 151.
    Appleman H. Localized and extensive expansions of the gastric mucosa: mucosal polyps and giant folds. In: Appleman H, ed. Pathology of the Esophagus Stomach and Duodenum. Contemporary Issues in Surgical Pathology. New York: Churchill-Livingstone; 1984:79–119.Google Scholar
  152. 152.
    Lewin K, Riddell R, Weinstein W. Gastrointestinal pathology and its clinical implications. New York: Igaku-Shoin; 1992:543–544.Google Scholar
  153. 153.
    Beneck D. Hypertrophic gastropathy in a newborn: a case report and review of the literature. Pediatr Pathol. 1994;14:213–221.PubMedGoogle Scholar
  154. 154.
    Burns B, Gay B. Menetier’s disease of the stomach in children. Am J Roentgenol Radium Ther Nucl Med. 1971; 103: 300–306.Google Scholar
  155. 155.
    Lachman R, Martin D, Vawter G. Thick gastric folds in childhood. Am J Roentgenol Radium Ther Nucl Med. 1971;112:83–92.PubMedGoogle Scholar
  156. 156.
    Chouraqui J, Roy C, Brochu P, et al. Menetrier’s disease in children: report of a patient and review of sixteen other cases. Gastroenterology. 1981;80:1042–1047.PubMedGoogle Scholar
  157. 157.
    Kraut J, Powell R, Hruby M, Lloyd-Still J. Menetrier’s disease in childhood: report of two cases and review of the literature. J Pediatr Surg. 1981;16:707–711.PubMedGoogle Scholar
  158. 158.
    Knight J, Matlak M, Condon V. Menetrier’s disease in children: report of a case and review of the literature. Pediatr Pathol. 1983;1:179–186.PubMedGoogle Scholar
  159. 159.
    Larsen B, Tarp U, Kristensen E. Familial giant hypertrophic gastritis (Menetrier’s disease]. Gut. 1987;28:1517–1521.PubMedGoogle Scholar
  160. 160.
    Faic F, Votava A, Tambic L, Manojlovic S. Hypertrophic gastritis in association with sepsis and death in a two month old infant. J Pediatr Gastroenterol Nutr. 1988;7:461–465.Google Scholar
  161. 161.
    Ragheb M, Ramadan A, Khalil M. Corrosive gastritis. Am J Surg. 1977;134:343–345.PubMedGoogle Scholar
  162. 162.
    Gezernik W, Schmaman A, Chappell J. Corrosive gastritis as a result of ferrous sulphate ingestion. South Afr Med J. 1980;57:151–154.Google Scholar
  163. 163.
    Laine L, Weinstein W. Subepithelial hemorrhages and erosions of human stomach. Dig Dis Sci. 1988;33:490–503.PubMedGoogle Scholar
  164. 164.
    Casaubon P, Vargas J, Ament M. Protracted hemorrhagic gastritis in an infant recovering from acute pancreatitis-successful management from prostaglandin E2 analogue. J Pediatr Gastroenterol Nutr. 1987;6:806–810.PubMedGoogle Scholar
  165. 165.
    Kazi S, Gunasekaran T, Berman J, et al. Gastric mucosal injuries in children from inflatable low-profile gastrostomy tubes. J Pediatr Gastroenterol Nutr. 1997;24:75–78.PubMedGoogle Scholar
  166. 166.
    Dixon M, O’Conner H, Axon A, et al. Reflux gastritis; distinct histopathological entity? J Clin Pathol. 1986;39:524–530.PubMedGoogle Scholar
  167. 167.
    Haber M, Lopez I. Gastric histologic findings in patients with nonsteroidal anti-inflammatory drug-associated gastric ulcer. Mod Pathol. 1999;12:592–598.PubMedGoogle Scholar
  168. 168.
    Dixon M, Neville P, Mapstone N, et al. Bile reflux gastritis and Barrett’s esophagus; further evidence of a role for duodenogas-tro-esophageal reflux? Gut. 2001;49:359–363.PubMedGoogle Scholar
  169. 169.
    Driman A, Wright C, Tougas V, Riddell R. Omeprazole produces parietal cell hypertrophy and hyperplasia in humans. Dig Dis Sci. 1996;41:2039–2047.PubMedGoogle Scholar
  170. 170.
    Choudry U, Boyce H, Coppola D. Proton pump inhibitor-associated gastric polyps. Am J Clin Pathol. 1998;110:615–621.Google Scholar
  171. 171.
    Cats A, Schenk E, Bloemena E, et al. Parietal cell protusions and fundic gland cysts during omeprazole maintenance treatment. Hum Pathol. 2000;31:684–690.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • James E. Dimmick
  • Gareth P. Jevon

There are no affiliations available

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